B2S3C9 (TPIS_TREPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase
Short name=TIM
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase

Gene names

Name:	tpiA
Ordered Locus Names:	TPASS_0537

Organism

Treponema pallidum subsp. pallidum (strain SS14) [Complete proteome] [HAMAP]

Taxonomic identifier

455434 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Treponema › Treponema pallidum › Treponema pallidum subsp. pallidum

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Triosephosphate isomerase HAMAP-Rule MF_00147		PRO_1000096545
Sites
	Active site	94	1	Electrophile By similarity
	Active site	166	1	Proton acceptor By similarity
	Binding site	9	1	Substrate By similarity
	Binding site	11	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2S3C9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: EF65741D5EE4D431	FASTA	249	26,540
	10 20 30 40 50 60 MRGYFIAGNW KMHKTCAEAV ALAQELVREL RGGPHTYMIA PSFTALDAVG KVLRGSNVLL 70 80 90 100 110 120 GAQDVSSEEW GAHTGEVSVL QLEDLGVQVV IVGHSERRHG RGENDKLINQ KVRRVLESGL 130 140 150 160 170 180 RVILCVGERL QEYEAGCTNE VVGTQVRAGM ADVCGSLMHN VTVAYEPVWA IGTGKTATPA 190 200 210 220 230 240 QANAVHAHIR SVVREMYGAA IAEALCIQYG GSMKAENARA LLAEEHIDGG LIGGASLEAA SFVPIARSV

References

[1]

"Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays." Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M. BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS14.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000805 Genomic DNA. Translation: ACD70958.1.
RefSeq	YP_001933537.1. NC_010741.1.
3D structure databases
ProteinModelPortal	B2S3C9.
SMR	B2S3C9. Positions 2-248.
ModBase	Search...
Protein-protein interaction databases
STRING	455434.TPASS_0537.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACD70958; ACD70958; TPASS_0537.
GeneID	6333109.
KEGG	tpp:TPASS_0537.
PATRIC	20528823. VBITrePal10923_0577.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HOG000226414.
KO	K01803.
OMA	SECRTYL.
ProtClustDB	PRK00042.
Enzyme and pathway databases
UniPathway	UPA00109; UER00189. UPA00138.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00147_B. TIM_B.
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
PANTHER	PTHR21139. PTHR21139. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_TREPS

Accession

Primary (citable) accession number: B2S3C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program