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B2S3B1 (RUVC_TREPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:TPASS_0517
OrganismTreponema pallidum subsp. pallidum (strain SS14) [Complete proteome] [HAMAP]
Taxonomic identifier455434 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_1000090570

Sites

Metal binding231Magnesium By similarity
Metal binding831Magnesium By similarity
Metal binding1561Magnesium By similarity
Metal binding1591Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
B2S3B1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: BD704CF266A5C714

FASTA19620,942
        10         20         30         40         50         60 
MHAQNVDIAP GSTSTVSIIV GIDPGLESTG YGVIEAGGGS LRCLTYGVIV TQSNQPSAAR 

        70         80         90        100        110        120 
LRHIFDTLQQ VISIYQPQYC AVETIYFAKN VTSALCVAQA RGVVLLAMAQ QHISVAEYAP 

       130        140        150        160        170        180 
NAIKKAITGI AQAEKRQVQH LVKILLNLKD IPHPDHAADA LAVAVTHVHC CMSSNYAVGS 

       190 
TRSRGAYVTL YKKGKR 

« Hide

References

[1]"Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SS14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000805 Genomic DNA. Translation: ACD70940.1.
RefSeqYP_001933519.1. NC_010741.1.
YP_008119259.1. NC_021508.1.

3D structure databases

ProteinModelPortalB2S3B1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING455434.TPASS_0517.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACD70940; ACD70940; TPASS_0517.
GeneID15843378.
6332839.
KEGGtpp:TPASS_0517.
PATRIC20528773. VBITrePal10923_0552.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012182.
KOK01159.
OMARQVQEMV.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycTPAL455434:GJ9E-544-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_TREPS
AccessionPrimary (citable) accession number: B2S3B1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families