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B2S337

- NADK_TREPS

UniProt

B2S337 - NADK_TREPS

Protein

NAD kinase

Gene

nadK

Organism
Treponema pallidum subsp. pallidum (strain SS14)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Proton acceptorUniRule annotation
    Binding sitei161 – 1611NADUniRule annotation
    Binding sitei180 – 1801NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi76 – 772NADUniRule annotation
    Nucleotide bindingi150 – 1512NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPAL455434:GJ9E-465-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:TPASS_0441
    OrganismiTreponema pallidum subsp. pallidum (strain SS14)
    Taxonomic identifieri455434 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000001202: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305NAD kinasePRO_1000120897Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi455434.TPASS_0441.

    Structurei

    3D structure databases

    ProteinModelPortaliB2S337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiGAEFCLN.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2S337-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRVCPQRP VAKSSGDAKV LLIVSTYKPR AAVLAADVVN FLSIRGFQCH    50
    TIEYDGLNKE SCARAGYMFA VSIGGDGTTL FAARCASPSG IPILAINLGR 100
    FGFIAPIEPR YWQQALSDYL AGGVRPAERA LISCTVTRAG KEIASCLALN 150
    DVVLSSGRVA RLTRAEVCFN DISFGVYEAD GIILATPTGS TAYSAACGGP 200
    ILDPDLDAFV LTPISALCLS NRPVVVPSSG VVRIKVLSMR HKETVLSVDG 250
    HELCTLQEED QLLASRSSCS ARLVFCTPHV FYHALCSKLA WSGSIFSRRG 300
    RRHDD 305
    Length:305
    Mass (Da):32,634
    Last modified:July 1, 2008 - v1
    Checksum:i4885B3DDE3C1CE58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000805 Genomic DNA. Translation: ACD70866.1.
    RefSeqiYP_001933445.1. NC_010741.1.
    YP_008119187.1. NC_021508.1.

    Genome annotation databases

    EnsemblBacteriaiACD70866; ACD70866; TPASS_0441.
    GeneIDi15843301.
    6333698.
    KEGGitpp:TPASS_0441.
    PATRICi20528605. VBITrePal10923_0473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000805 Genomic DNA. Translation: ACD70866.1 .
    RefSeqi YP_001933445.1. NC_010741.1.
    YP_008119187.1. NC_021508.1.

    3D structure databases

    ProteinModelPortali B2S337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 455434.TPASS_0441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACD70866 ; ACD70866 ; TPASS_0441 .
    GeneIDi 15843301.
    6333698.
    KEGGi tpp:TPASS_0441.
    PATRICi 20528605. VBITrePal10923_0473.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi GAEFCLN.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci TPAL455434:GJ9E-465-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
      Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
      BMC Microbiol. 8:76-76(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SS14.

    Entry informationi

    Entry nameiNADK_TREPS
    AccessioniPrimary (citable) accession number: B2S337
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3