B2S303 (MURI_TREPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	TPASS_0406

Organism

Treponema pallidum subsp. pallidum (strain SS14) [Complete proteome] [HAMAP]

Taxonomic identifier

455434 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Glutamate racemase HAMAP MF_00258		PRO_1000114073

Sequences

	Sequence		Length	Mass (Da)
	B2S303 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: AC224098FC8928E0	FASTA	268	29,449
	10 20 30 40 50 60 MSDRREQFQY AFLDSGIGGL PYAHALRVRV PEASLVYVAD RVYFPYGNKS SAQIIARASA 70 80 90 100 110 120 VLQKVQTNFS PHIVVLACNS MSVNALEFLR AQVSVPVVGV VPAIKQAVAC SHKKHIGVLA 130 140 150 160 170 180 TQCTITHPYT ACLRAQFGAG CVFQMRADAR LIECLERGLI FEVEDMQREA VARSVMPFQE 190 200 210 220 230 240 AGVDVLVLAC THFVHVRHLF QDCVGTSCTV VDSLEGVVRR TLRLCPPQSQ LRGNAACYVT 250 260 GARDAVCAAR YARYAQHFGL RWAGFLDV

References

[1]

"Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays." Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M. BMC Microbiol. 8:76-76(2008) [PubMed: 18482458] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SS14.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000805 Genomic DNA. Translation: ACD70832.1.
RefSeq	YP_001933411.1. NC_010741.1.
3D structure databases
ProteinModelPortal	B2S303.
ModBase	Search...
Protein-protein interaction databases
STRING	B2S303.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6332997.
GenomeReviews	Gene locus TPASS_0406 in contig CP000805_GR.
KEGG	tpp:TPASS_0406.
PATRIC	20528527. VBITrePal10923_0434.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG731640.
OMA	VPMVEEG.
ProtClustDB	CLSK218687.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 1 hit.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_TREPS

Accession

Primary (citable) accession number: B2S303

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 1, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program