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B2S2S8 (B2S2S8_TREPS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL ACD70757.1
Ordered Locus Names:TPASS_0331
OrganismTreponema pallidum subsp. pallidum (strain SS14) [Complete proteome] [HAMAP]
Taxonomic identifier455434 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 146NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding32 – 343NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding74 – 763NADP By similarity PIRSR PIRSR000109-3
Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region186 – 1872Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1831Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1901Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021NADP By similarity PIRSR PIRSR000109-3
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1911Substrate By similarity PIRSR PIRSR000109-2
Binding site2601Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2871Substrate By similarity PIRSR PIRSR000109-2
Binding site4511Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4571Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B2S2S8 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: FB69CCCA98DEE6B5

FASTA48852,767
        10         20         30         40         50         60 
MGADIGFIGL AVMGENLVLN IERNGFSVAV FNRTTTVVDR FLAGRAHGKR ITGAHSIAEL 

        70         80         90        100        110        120 
VSLLARPRKI MLMVKAGSAV DAVIDQILPL LEKGDLVIDG GNSHYQDTIR RMHALEAAGI 

       130        140        150        160        170        180 
HFIGTGVSGG EEGALRGPSL MPGGSAQAWP LVSPIFCAIA AKADDGTPCC DWVGSDGAGH 

       190        200        210        220        230        240 
YVKMIHNGIE YGDMQIIAEG YWFMKHALGM SYEHMHHTFT RWNTGRLHSY LIEITAAILA 

       250        260        270        280        290        300 
HQDTDGTPLL EKILDAAGQK GTGRWTCVAA LEEGSPLTLI TESVMARSLS AQKQARCKAH 

       310        320        330        340        350        360 
RVFGSPVKVS KAETLSAQQR EELVSALEDA LYCAKIVSYA QGFELLSHTA KRRGWTLDFS 

       370        380        390        400        410        420 
RIASLWRGGC IIRSGFLSKI SAAFAQQHDL ENLVLAPFFA EELKRACPGW RTIVAESVRQ 

       430        440        450        460        470        480 
ALPVPALSAA LAWFDGFTGA ALPANLLQAQ RDYFGAHTYE RTDAPRGEFF HTNWTGTGGD 


TIAGTYSI

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References

[1]"Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays."
Matejkova P., Strouhal M., Smajs D., Norris S.J., Palzkill T., Petrosino J.F., Sodergren E., Norton J.E., Singh J., Richmond T.A., Molla M.N., Albert T.J., Weinstock G.M.
BMC Microbiol. 8:76-76(2008) [PubMed: 18482458] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000805 Genomic DNA. Translation: ACD70757.1.
RefSeqYP_001933336.1. NC_010741.1.

3D structure databases

ProteinModelPortalB2S2S8.
SMRB2S2S8. Positions 1-475.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2S2S8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6333465.
GenomeReviewsGene locus TPASS_0331 in contig CP000805_GR.
KEGGtpp:TPASS_0331.
PATRIC20528359. VBITrePal10923_0351.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286913.
OMASNYPDTN.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB2S2S8_TREPS
AccessionPrimary (citable) accession number: B2S2S8
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info