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B2S1A8 (MURG_BORHD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BH0767
OrganismBorrelia hermsii (strain DAH) [Complete proteome] [HAMAP]
Taxonomic identifier314723 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_1000090406

Sequences

Sequence LengthMass (Da)Tools
B2S1A8 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 9D7091B515C8ED08

FASTA36240,771
        10         20         30         40         50         60 
MNTKKRIFFT GGGTGGHVFP GIAIISKLKE LDTNIEFFWL GQKGSMEDNI IKEHEYIKFI 

        70         80         90        100        110        120 
AIPSGKLRRY FSLQNFTDVF KVIFGIIKSF FIIKKYKPQI IYATGGFVSS PPIIAASLLR 

       130        140        150        160        170        180 
VKSITHEMDL DPGLATKINS KFASKIHISF KESTKYFKNK NVLYTGSPIR KEFSNPNPNI 

       190        200        210        220        230        240 
ITELTQNTKK PIISIFGGSL GAEVLNKLTL NIKNKIDAYF IHQCGKNLDA TRENNYLRSQ 

       250        260        270        280        290        300 
FFNAEEMASI IKFSNIIISR AGAGAIKEFA SAGACVIFIP FVKGSRGDQV RNTKILEEQN 

       310        320        330        340        350        360 
ACLKIDEENL SESQIIDMIK EILTNKEKFD ILKNNIKKFH NQDSSNLIAN LLLKDFEDIN 


AS

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References

[1]"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DAH.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000048 Genomic DNA. Translation: AAX17262.1.
RefSeqYP_001884184.1. NC_010673.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2S1A8.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000006767; EBBORP00000006191; EBBORG00000006767.
GeneID6277065.
GenomeReviewsGene locus BH0767 in contig CP000048_GR.
KEGGbhr:BH0767.
PATRIC20568918. VBIBorHer61105_0771.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007289.
HOGENOMHBG617076.
OMAHICGKGN.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBHER314723:BH0767-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BORHD
AccessionPrimary (citable) accession number: B2S1A8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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