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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Borrelia hermsii (strain HS1 / DAH)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHER314723:GJES-592-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:BH0594
OrganismiBorrelia hermsii (strain HS1 / DAH)
Taxonomic identifieri314723 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorrelia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Arginine--tRNA ligasePRO_1000095336Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi314723.BH0594.

Structurei

3D structure databases

ProteinModelPortaliB2S0U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 13711"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
KOiK01887.
OMAiDFQGNTG.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2S0U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKIKKDLK DIISKTIKEL ALRESIKLEE INIIMQKPPK SELGDLSILI
60 70 80 90 100
FEFSKILKLN TSIITEEIIK QIGDKYATKA MGPYLNIKFN RKEYIKDTIK
110 120 130 140 150
KVNEQKEKYG INNVLKNKRI IIEFSSPNTN KPLHIGHLRN DIIGESLSRI
160 170 180 190 200
LKASGAQVTK INLINDRGTH ICKSMLAYKK FGNNTTPELS LKKGDHLIGD
210 220 230 240 250
FYVKYNEYAK NNEMAEDEIQ QLLCKWEEGD EKTVQLWKKL NQWAIEGIKA
260 270 280 290 300
TYKLTNITFD KIYLESEIFK IGREIILKGL EEGLCYKRED GAICIDIPTE
310 320 330 340 350
KNEISEQQFK QKVLLRANGT SIYLTQDLGN IVTRKNEFDF DEMIYVVGSE
360 370 380 390 400
QIHHFKTLFY VANKLGITKE NNLVHLSYGM VNLPEGKMKS REGNVIDADN
410 420 430 440 450
LIHDLSESII LEIKKRNSDK KDYQEIALNI SLGAIHYYLL KTAIHKDILF
460 470 480 490 500
NKEESLSFTG NSGPYIQYVG ARINSILEKY DELNLSNETI NFDLLVNENE
510 520 530 540 550
WEIIKIISEF EEHIIKASKD RNPSVIANYS YLLAKSFSTY YQDTKIIDKN
560 570 580
KPELTHARID LSKAVLQTIK NCMHLLNIPY MKKM
Length:584
Mass (Da):67,429
Last modified:July 1, 2008 - v1
Checksum:i4536CDFA4D5D8658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000048 Genomic DNA. Translation: AAX17098.1.
RefSeqiWP_012422349.1. NC_010673.1.

Genome annotation databases

EnsemblBacteriaiAAX17098; AAX17098; BH0594.
KEGGibhr:BH0594.
PATRICi20568544. VBIBorHer61105_0596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000048 Genomic DNA. Translation: AAX17098.1.
RefSeqiWP_012422349.1. NC_010673.1.

3D structure databases

ProteinModelPortaliB2S0U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314723.BH0594.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX17098; AAX17098; BH0594.
KEGGibhr:BH0594.
PATRICi20568544. VBIBorHer61105_0596.

Phylogenomic databases

eggNOGiCOG0018.
KOiK01887.
OMAiDFQGNTG.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciBHER314723:GJES-592-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
    Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS1 / DAH.

Entry informationi

Entry nameiSYR_BORHD
AccessioniPrimary (citable) accession number: B2S0U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: July 22, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.