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B2S0R1 (B2S0R1_BORHD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:BH0561
OrganismBorrelia hermsii (strain DAH) [Complete proteome] [HAMAP]
Taxonomic identifier314723 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region124 – 1263Substrate binding By similarity PIRSR PIRSR000109-2
Region182 – 1832Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1791Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1861Proton donor By similarity PIRSR PIRSR000109-1
Binding site981Substrate By similarity PIRSR PIRSR000109-2
Binding site1871Substrate By similarity PIRSR PIRSR000109-2
Binding site2551Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2821Substrate By similarity PIRSR PIRSR000109-2
Binding site4401Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B2S0R1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 40B554AEB1A1E15E

FASTA46452,336
        10         20         30         40         50         60 
MDVGIYGLGV MGSNLALNIA DSGFNVSVYN RDSDKTEIFL VNNAHKKIHG FKDIETFIGS 

        70         80         90        100        110        120 
LKKPRKIILM ILSSAVDEVI EQILPLVEKF DIIIDGGNSH YKDTVRREQG LSSKDIYFVG 

       130        140        150        160        170        180 
LGISGGEKGA RFGPSLMYGG SKKAYGLIEP ILNKIAAKTS VGDICSAYVG ENGAGHYVKM 

       190        200        210        220        230        240 
IHNGIEYADM QLISEAYFFM KRAFNLDNLR ISEVFDKWGE GDLSSYLIEI TSNILKYKEN 

       250        260        270        280        290        300 
NEYLLDKILD VANQKGTGKW VSIEALQLNV PANLIFESVF ARFLSGLKHE RVIASDILKM 

       310        320        330        340        350        360 
DVDSAEFDLS DWILDLYYAL LVSKILAYVQ GFMMLKSASV NYSWDLNLGK ISLIWREGCI 

       370        380        390        400        410        420 
IKSVFLDKIK LAYDKNPHLI NLLFDDYFLD IIRNHQKSLR RIVSKASEIG IPLPAFYASL 

       430        440        450        460 
SFLDSYSTNY LPANLIQAQR DFFGAHSFER IDSKRGEFFH STWR

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References

[1]"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000048 Genomic DNA. Translation: AAX17067.1.
RefSeqYP_001883987.1. NC_010673.1.

3D structure databases

ProteinModelPortalB2S0R1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB2S0R1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000006774; EBBORP00000006198; EBBORG00000006774.
GeneID6276699.
GenomeReviewsGene locus BH0561 in contig CP000048_GR.
KEGGbhr:BH0561.
PATRIC20568474. VBIBorHer61105_0562.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007500.
HOGENOMHBG286913.
OMAMEHNEMA.
ProtClustDBPRK09287.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB2S0R1_BORHD
AccessionPrimary (citable) accession number: B2S0R1
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info