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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Borrelia hermsii (strain HS1 / DAH)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei254ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BH0372
OrganismiBorrelia hermsii (strain HS1 / DAH)
Taxonomic identifieri314723 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorrelia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900541 – 491Glutamate--tRNA ligaseAdd BLAST491

Proteomic databases

PRIDEiB2S076

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2S076
SMRiB2S076
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi251 – 255"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

B2S076-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRVRYAPS PTGLQHIGGI RTALFNYFFA RSCGGKFLLR IEDTDQSRYF
60 70 80 90 100
QEAEEDLYQS LKWLGIDFDE GPTCGGPYEP YVQSKRTAIY QKYAKQLIEL
110 120 130 140 150
GNAYYCYCKP DRLERIRKIQ TVNKMAPGYD RHCRNLSESE IKDVLSLGIT
160 170 180 190 200
PVIRFKIPLD GETCFNDILL DKVTWANKDI SPDPVILKSD GLPTYHLANV
210 220 230 240 250
VDDHLMEISH VLRAQEWVSS GPLHVLLYNA FGWKPPIYCH LPMVMGSDGQ
260 270 280 290 300
KLSKRHGATA LKQFIADGYL PEAIINYITL LGWSYDDKSE FFTKNELQRL
310 320 330 340 350
FSIERVNKSP AVFDYNKLDF FNSHYIREKG DDELAKLLIP FLQKAGYIKE
360 370 380 390 400
DINSCDEQKL MLLIPLIKPR IRKLSEAVTM LKFFYEDIKT WNLDEFLGKK
410 420 430 440 450
KTASDIYLLL EKIKPVLEDF ETRMLPDNEK IFYNFAKENN LKIGEVLLPI
460 470 480 490
RIAVLGSKVS PPLFDSLQLL GKVKVFDRIS QAQQFLKRHE L
Length:491
Mass (Da):56,757
Last modified:July 1, 2008 - v1
Checksum:i88075125E1063611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000048 Genomic DNA Translation: AAX16882.1
RefSeqiWP_012422139.1, NC_010673.1

Genome annotation databases

EnsemblBacteriaiAAX16882; AAX16882; BH0372
KEGGibhr:BH0372

Similar proteinsi

Entry informationi

Entry nameiSYE_BORHD
AccessioniPrimary (citable) accession number: B2S076
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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