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B2S014 (MRAY_BORHD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BH0303
OrganismBorrelia hermsii (strain DAH) [Complete proteome] [HAMAP]
Taxonomic identifier314723 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090595

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane126 – 14520Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane254 – 27421Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane328 – 34821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B2S014 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: B1EFA690C5DF17B8

FASTA35139,500
        10         20         30         40         50         60 
MFDLLGLRLL HYITFRTAYA TIFAFLLALI FGPFIILRLK KLKLDQILRE DGPKRHLSEK 

        70         80         90        100        110        120 
MGIPTMGGIL IFFCVLVSLF FWINLWNVYF LIVLFVMISF ACLGFMDDLL KIKRKNADGL 

       130        140        150        160        170        180 
NPRFKIYGQI LFSCISVTML YYFGGEHISI IYFPFFKSLK LDLGVLYIPF GMFILISASN 

       190        200        210        220        230        240 
SFNLTDGLDG LAIGLSIVVT GALVIIAYLT SRVDFATYLN IPNIKGSEEL VIFLGALLGG 

       250        260        270        280        290        300 
SFGFLWFNAY PAKIMMGDTG SLSIGAVLGM TALILKSEIL FAILAGVFVL ETLSVIIQVA 

       310        320        330        340        350 
VYKKTKKRVF KMAPLHHHFE ELGWSETQVV IRFWIIGLIF AIIALSTLKI R

« Hide

References

[1]"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DAH.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000048 Genomic DNA. Translation: AAX16820.1.
RefSeqYP_001883740.1. NC_010673.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB2S014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000006942; EBBORP00000006366; EBBORG00000006942.
GeneID6276684.
GenomeReviewsGene locus BH0303 in contig CP000048_GR.
KEGGbhr:BH0303.
PATRIC20567932. VBIBorHer61105_0304.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007216.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBHER314723:BH0303-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BORHD
AccessionPrimary (citable) accession number: B2S014
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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