B2RZW9 (UPPP_BORHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	BH0258

Organism

Borrelia hermsii (strain DAH) [Complete proteome] [HAMAP]

Taxonomic identifier

314723 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia hermsii

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000197352
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	182 – 202	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B2RZW9 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 7B5FB25580612D9E	FASTA	264	29,810
	10 20 30 40 50 60 MENVLRVVIL GFIQGIAEFL PISSSGHLLL LKKFMHIDLP IVFDIYLHLA TVLVVMIYYC 70 80 90 100 110 120 RRILELVAVL VKFVLGKTTE CDFAKLRLIL LILIITIITA FIGIFIEMFK GLFTLNLVLI 130 140 150 160 170 180 NFIVTSILLF LLESRIVIFD LKRNILLAGC LIGTMQGIGA MPGISRSGIT IFASVLLGFS 190 200 210 220 230 240 RSESFEISFL SLIPIVFGSL LLKYKELFES DMLFSIFEIN LGAIIAFLVG LFSISLFVKM 250 260 LQDSKLYYFS VYLIILVSLV YFLF

References

[1]

"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever." Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DAH.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000048 Genomic DNA. Translation: AAX16775.1.
RefSeq	YP_001883695.1. NC_010673.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	314723.BH0258.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX16775; AAX16775; BH0258.
GeneID	6276831.
KEGG	bhr:BH0258.
PATRIC	20567842. VBIBorHer61105_0259.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	TISAMMF.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BHER314723:GJES-254-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_BORHD

Accession

Primary (citable) accession number: B2RZW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program