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B2RZW9

- UPPP_BORHD

UniProt

B2RZW9 - UPPP_BORHD

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Borrelia hermsii (strain HS1 / DAH)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBHER314723:GJES-254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:BH0258
    OrganismiBorrelia hermsii (strain HS1 / DAH)
    Taxonomic identifieri314723 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
    ProteomesiUP000008834: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Undecaprenyl-diphosphatasePRO_1000197352Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314723.BH0258.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei89 – 10921HelicalUniRule annotationAdd
    BLAST
    Transmembranei112 – 13221HelicalUniRule annotationAdd
    BLAST
    Transmembranei145 – 16521HelicalUniRule annotationAdd
    BLAST
    Transmembranei182 – 20221HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei244 – 26421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiPIVFDIY.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2RZW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENVLRVVIL GFIQGIAEFL PISSSGHLLL LKKFMHIDLP IVFDIYLHLA    50
    TVLVVMIYYC RRILELVAVL VKFVLGKTTE CDFAKLRLIL LILIITIITA 100
    FIGIFIEMFK GLFTLNLVLI NFIVTSILLF LLESRIVIFD LKRNILLAGC 150
    LIGTMQGIGA MPGISRSGIT IFASVLLGFS RSESFEISFL SLIPIVFGSL 200
    LLKYKELFES DMLFSIFEIN LGAIIAFLVG LFSISLFVKM LQDSKLYYFS 250
    VYLIILVSLV YFLF 264
    Length:264
    Mass (Da):29,810
    Last modified:July 1, 2008 - v1
    Checksum:i7B5FB25580612D9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000048 Genomic DNA. Translation: AAX16775.1.
    RefSeqiWP_012422032.1. NC_010673.1.
    YP_001883695.1. NC_010673.1.

    Genome annotation databases

    EnsemblBacteriaiAAX16775; AAX16775; BH0258.
    GeneIDi6276831.
    KEGGibhr:BH0258.
    PATRICi20567842. VBIBorHer61105_0259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000048 Genomic DNA. Translation: AAX16775.1 .
    RefSeqi WP_012422032.1. NC_010673.1.
    YP_001883695.1. NC_010673.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314723.BH0258.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX16775 ; AAX16775 ; BH0258 .
    GeneIDi 6276831.
    KEGGi bhr:BH0258.
    PATRICi 20567842. VBIBorHer61105_0259.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi PIVFDIY.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BHER314723:GJES-254-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
      Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HS1 / DAH.

    Entry informationi

    Entry nameiUPPP_BORHD
    AccessioniPrimary (citable) accession number: B2RZW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3