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B2RZW1

- SYL_BORHD

UniProt

B2RZW1 - SYL_BORHD

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia hermsii (strain HS1 / DAH)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBHER314723:GJES-246-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BH0251
    OrganismiBorrelia hermsii (strain HS1 / DAH)
    Taxonomic identifieri314723 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
    ProteomesiUP000008834: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842Leucine--tRNA ligasePRO_1000091293Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314723.BH0251.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RZW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5512"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RZW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEYNFTKIE KKWQDYWDKH KTYKVNEDPN IPKEKRIYIL DMFPYPSANG    50
    LHVGHPEGYT ATDILTRYKL LNGFNVLHPI GFDSFGLPAE NYAIQTGEHP 100
    KKITEKNIKK FKEQIKALGF AYDWDREIRT HDENYYKWTQ WIFLKLYKKG 150
    LAYTKEMPVW YCPDLGTVLS NEEVIQTPDG PRSERGFHKV KRKPLRQWIL 200
    KITEYAERLI KDLEEIDWPE SVKEMQKNWI GKSTGAEIEF SVKASKEKIK 250
    VFTTRPDTIF GVTYLVLAPE HSIVDKITKD EFKPMIVEYR ERETLKSDLE 300
    RTSLEKDKTG VFTGAYAINP ITGEEIPIWI GSYILGTYGT GAVMSVPAHD 350
    ARDFEFAKKY NLPIKQVVSQ TGNNEILTQP FTENGISINT PEEFNNLKTD 400
    EIKERVIKWL TENKKGQKKV NYKLRDWIFS RQRYWGEPIP IILDDDLNEI 450
    PLEEDELPLR LPEIENYKPS GTGESPLSRI QDWVNIKRNG KTYKRETNTM 500
    PQWAGSCWYY IRYLDPNNDN EFASKEKINY WMPVDLYIGG AEHSVLHLLY 550
    ARFWHKVLYD LGYVNTKEPF KKLINQGMIT SFAYQDENGI LIPNDEVEKK 600
    DNKFFSKKNN KELKQIVAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG 650
    PLTDSKPWNT QGLIGIFRFL NKIWTIKNKE LTKESASKEI ISELHKTIKK 700
    VTEDIENLNF NTAISSLMIF INELLKHDKN YLEIFKPLTI ILSPFAPHLG 750
    EELWEYMGET PSIFKSAKWP EYDPNLIIDN TREIVLQING KIKDKIILNK 800
    GTNEEALKSI ALKNHKIMQN IQNKQIIKII TVKDKLINIV TR 842
    Length:842
    Mass (Da):98,521
    Last modified:July 1, 2008 - v1
    Checksum:i6826EF84209307EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000048 Genomic DNA. Translation: AAX16767.1.
    RefSeqiYP_001883687.1. NC_010673.1.

    Genome annotation databases

    EnsemblBacteriaiAAX16767; AAX16767; BH0251.
    GeneIDi6277013.
    KEGGibhr:BH0251.
    PATRICi20567826. VBIBorHer61105_0251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000048 Genomic DNA. Translation: AAX16767.1 .
    RefSeqi YP_001883687.1. NC_010673.1.

    3D structure databases

    ProteinModelPortali B2RZW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314723.BH0251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX16767 ; AAX16767 ; BH0251 .
    GeneIDi 6277013.
    KEGGi bhr:BH0251.
    PATRICi 20567826. VBIBorHer61105_0251.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BHER314723:GJES-246-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
      Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HS1 / DAH.

    Entry informationi

    Entry nameiSYL_BORHD
    AccessioniPrimary (citable) accession number: B2RZW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3