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B2RZW1

- SYL_BORHD

UniProt

B2RZW1 - SYL_BORHD

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Protein

Leucine--tRNA ligase

Gene
leuS, BH0251
Organism
Borrelia hermsii (strain HS1 / DAH)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHER314723:GJES-246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BH0251
OrganismiBorrelia hermsii (strain HS1 / DAH)
Taxonomic identifieri314723 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
ProteomesiUP000008834: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842Leucine--tRNA ligaseUniRule annotationPRO_1000091293Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314723.BH0251.

Structurei

3D structure databases

ProteinModelPortaliB2RZW1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5512"HIGH" regionUniRule annotationAdd
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RZW1-1 [UniParc]FASTAAdd to Basket

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MSEYNFTKIE KKWQDYWDKH KTYKVNEDPN IPKEKRIYIL DMFPYPSANG    50
LHVGHPEGYT ATDILTRYKL LNGFNVLHPI GFDSFGLPAE NYAIQTGEHP 100
KKITEKNIKK FKEQIKALGF AYDWDREIRT HDENYYKWTQ WIFLKLYKKG 150
LAYTKEMPVW YCPDLGTVLS NEEVIQTPDG PRSERGFHKV KRKPLRQWIL 200
KITEYAERLI KDLEEIDWPE SVKEMQKNWI GKSTGAEIEF SVKASKEKIK 250
VFTTRPDTIF GVTYLVLAPE HSIVDKITKD EFKPMIVEYR ERETLKSDLE 300
RTSLEKDKTG VFTGAYAINP ITGEEIPIWI GSYILGTYGT GAVMSVPAHD 350
ARDFEFAKKY NLPIKQVVSQ TGNNEILTQP FTENGISINT PEEFNNLKTD 400
EIKERVIKWL TENKKGQKKV NYKLRDWIFS RQRYWGEPIP IILDDDLNEI 450
PLEEDELPLR LPEIENYKPS GTGESPLSRI QDWVNIKRNG KTYKRETNTM 500
PQWAGSCWYY IRYLDPNNDN EFASKEKINY WMPVDLYIGG AEHSVLHLLY 550
ARFWHKVLYD LGYVNTKEPF KKLINQGMIT SFAYQDENGI LIPNDEVEKK 600
DNKFFSKKNN KELKQIVAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG 650
PLTDSKPWNT QGLIGIFRFL NKIWTIKNKE LTKESASKEI ISELHKTIKK 700
VTEDIENLNF NTAISSLMIF INELLKHDKN YLEIFKPLTI ILSPFAPHLG 750
EELWEYMGET PSIFKSAKWP EYDPNLIIDN TREIVLQING KIKDKIILNK 800
GTNEEALKSI ALKNHKIMQN IQNKQIIKII TVKDKLINIV TR 842
Length:842
Mass (Da):98,521
Last modified:July 1, 2008 - v1
Checksum:i6826EF84209307EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000048 Genomic DNA. Translation: AAX16767.1.
RefSeqiYP_001883687.1. NC_010673.1.

Genome annotation databases

EnsemblBacteriaiAAX16767; AAX16767; BH0251.
GeneIDi6277013.
KEGGibhr:BH0251.
PATRICi20567826. VBIBorHer61105_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000048 Genomic DNA. Translation: AAX16767.1 .
RefSeqi YP_001883687.1. NC_010673.1.

3D structure databases

ProteinModelPortali B2RZW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 314723.BH0251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX16767 ; AAX16767 ; BH0251 .
GeneIDi 6277013.
KEGGi bhr:BH0251.
PATRICi 20567826. VBIBorHer61105_0251.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BHER314723:GJES-246-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
    Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HS1 / DAH.

Entry informationi

Entry nameiSYL_BORHD
AccessioniPrimary (citable) accession number: B2RZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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