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Reviewed, UniProtKB/Swiss-Prot B2RZV0 (GLPK_BORHD)

Last modified November 3, 2009. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: BH0241
OrganismBorrelia hermsii (strain DAH) [Complete proteome] [HAMAP]
Taxonomic identifier314723 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

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Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity.

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Glycerol kinase HAMAP MF_00186
PRO_1000098718

Regions

Nucleotide binding409 – 4135ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
B2RZV0-1 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 0BDADE725842DAA2

FASTA49555,193
        10         20         30         40         50         60 
MKYILSLDQG TTSSRAVIFD KNANIKGFAK KEFKQIYPHP SWVEHDPNEI WGSLLGVMAE 

        70         80         90        100        110        120 
ALANARTFPN NIEAIGITNQ RETTIIWDRN TGHPIYNAIV WQDRRTAQLC DELKSKGKDK 

       130        140        150        160        170        180 
IFLQKTGLVL DAYFSGTKIK WILDNVAGAR KRAEKGELCF GTIDTWIVWN LTKGKIHITD 

       190        200        210        220        230        240 
YSNASRTLLL NIKSLKWDCD LLQILDIPKS LLPELKQSSE VYGKTDASAL GTEIIISGIA 

       250        260        270        280        290        300 
GDQFAATFGQ ACLQKGMAKN TYGTGCFVTV NIGKKPIINE QKILTSIAWG RKNSITYVFE 

       310        320        330        340        350        360 
GSVFIGGAVI QWLRDNLELF RKSGDAEAVA ASVDNNGGIY FVPAFVGLGT PHWDPYARGM 

       370        380        390        400        410        420 
IIGLTRSSTK EHITRAALES IALQSFDVLT EMQNSIQEFE IKELRVDGGA SKNNLLMQFQ 

       430        440        450        460        470        480 
ADILQCNVVR PKITETTALG SAYLAGLAVG YWESAEEITS LWKSDKIFEP SMEKSKREDL 

       490 
IYNWNKAIKR AKAWI

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References

[1]"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000048 Genomic DNA. Translation: AAX16756.1.
RefSeqYP_001883676.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6277081.
GenomeReviewsGene locus BH0241 in contig CP000048_GR.
KEGGbhr:BH0241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIAQREFT.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_BORHD
AccessionPrimary (citable) accession number: B2RZV0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: November 3, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents