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B2RZR0 (DDL_BORHD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:BH0200
OrganismBorrelia hermsii (strain HS1 / DAH) [Complete proteome] [HAMAP]
Taxonomic identifier314723 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000091162

Regions

Domain135 – 345211ATP-grasp
Nucleotide binding168 – 22356ATP By similarity

Sites

Metal binding2981Magnesium or manganese 1 By similarity
Metal binding3121Magnesium or manganese 1 By similarity
Metal binding3121Magnesium or manganese 2 By similarity
Metal binding3141Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RZR0 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: FFC7A489AF0D8A86

FASTA36541,559
        10         20         30         40         50         60 
MMKKNLMLIF GGVSFEHEIS LRSAYGIYSA LMKLDKYNLY PSFIDKITGI WYLLDSVPDA 

        70         80         90        100        110        120 
PELIKRDSSA IISLIPGCGI FVNDEDLEID VVFPIVHGRT GEDGAIQGFL KMMDIPCVGA 

       130        140        150        160        170        180 
GILGSAISIN KYFCKLLLKS FNIPLVPFIG FRKYDYFLDK EGIKKDIKQS LNYPVIVKPA 

       190        200        210        220        230        240 
MLGSSIGISI AYNDTQIEKC IEEAFEYDLT VVVEKFMKVR EIECSVIGNE QIKIFTPGEI 

       250        260        270        280        290        300 
VVQDFVFYDY DAKYSTIPGN SVVFNIPARL DMKHLLDIKE YAFLTYKCLE LRGMARIDFL 

       310        320        330        340        350        360 
IEKDTNLIYV NEINTIPGFT DISMFSKMCE HDGLDYESLV DNLVSLAFQS YAKRKERIDF 


KRLEN 

« Hide

References

[1]"The genome sequence of Borrelia hermsii and Borrelia turicatae: comparative analysis of two agents of endemic N. America relapsing fever."
Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T., Schwan T.G.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HS1 / DAH.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000048 Genomic DNA. Translation: AAX16716.1.
RefSeqYP_001883636.1. NC_010673.1.

3D structure databases

ProteinModelPortalB2RZR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING314723.BH0200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX16716; AAX16716; BH0200.
GeneID6276913.
KEGGbhr:BH0200.
PATRIC20567710. VBIBorHer61105_0197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK14570.

Enzyme and pathway databases

BioCycBHER314723:GJES-191-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_BORHD
AccessionPrimary (citable) accession number: B2RZR0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways