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Protein

Protein Mis18-alpha

Gene

Mis18a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76ZincPROSITE-ProRule annotation1
Metal bindingi79ZincPROSITE-ProRule annotation1
Metal bindingi132ZincPROSITE-ProRule annotation1
Metal bindingi135ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Mis18-alpha
Gene namesi
Name:Mis18a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310778. Mis18a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003598821 – 223Protein Mis18-alphaAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Cross-linki153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei223PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB2RZC4.
PRIDEiB2RZC4.

Expressioni

Gene expression databases

GenevisibleiB2RZC4. RN.

Interactioni

Subunit structurei

Homodimer, and heterodimer with OIP5/MIS18B. Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037080.

Structurei

3D structure databases

SMRiB2RZC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 169Mis18PROSITE-ProRule annotationAdd BLAST99

Sequence similaritiesi

Belongs to the mis18 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKYV. Eukaryota.
ENOG41125JV. LUCA.
HOGENOMiHOG000059535.
HOVERGENiHBG108147.
InParanoidiB2RZC4.
KOiK11564.
OrthoDBiEOG091G0KM2.
PhylomeDBiB2RZC4.
TreeFamiTF333200.

Family and domain databases

InterProiView protein in InterPro
IPR034752. Mis18.
IPR004910. Yippee/Mis18/Cereblon.
PfamiView protein in Pfam
PF03226. Yippee-Mis18. 1 hit.
PROSITEiView protein in PROSITE
PS51793. MIS18. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RZC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTFSLEPC STSSSCNHQG KRSESSLLEK RLSEDSSRHW RLQKWASMSS
60 70 80 90 100
ADASRTLLER REEKAAAAEN PLVFLCTRCR RPLGDSLTWV ASQEDTNCIL
110 120 130 140 150
LRSVSSNVSV DKEQKLSKCR DEDGCILETL YCSGCSLSLG YVYRCTPKNL
160 170 180 190 200
DYKRNLFCLS VEAVESYTLG SSEQQIVSEE EFFNLESRVE IEKSIKQMED
210 220
VLTVMQAKLW EVESKLSKAG RYS
Length:223
Mass (Da):25,216
Last modified:July 1, 2008 - v1
Checksum:iD7CFCC75AEFF990E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167102 mRNA. Translation: AAI67102.1.
RefSeqiNP_001120995.2. NM_001127523.2.
UniGeneiRn.137223.

Genome annotation databases

GeneIDi288272.
KEGGirno:288272.
UCSCiRGD:1310778. rat.

Similar proteinsi

Entry informationi

Entry nameiMS18A_RAT
AccessioniPrimary (citable) accession number: B2RZC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 1, 2008
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families