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Protein

Protein Mis18-alpha

Gene

Mis18a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-RNO-606279. Deposition of new CENPA-containing nucleosomes at the centromere.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Mis18-alpha
Gene namesi
Name:Mis18a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310778. Mis18a.

Subcellular locationi

  • Nucleus By similarity
  • Chromosomecentromere By similarity

  • Note: Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Protein Mis18-alphaPRO_0000359882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei223 – 2231PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RZC4.
PRIDEiB2RZC4.

Expressioni

Gene expression databases

GenevisibleiB2RZC4. RN.

Interactioni

Subunit structurei

Homodimer, and heterodimer with MIS18B. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037080.

Family & Domainsi

Sequence similaritiesi

Belongs to the mis18 family.Curated

Phylogenomic databases

eggNOGiENOG410IKYV. Eukaryota.
ENOG41125JV. LUCA.
HOGENOMiHOG000059535.
HOVERGENiHBG108147.
InParanoidiB2RZC4.
KOiK11564.
OMAiEDSSRHQ.
OrthoDBiEOG70KGSQ.
PhylomeDBiB2RZC4.
TreeFamiTF333200.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RZC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTFSLEPC STSSSCNHQG KRSESSLLEK RLSEDSSRHW RLQKWASMSS
60 70 80 90 100
ADASRTLLER REEKAAAAEN PLVFLCTRCR RPLGDSLTWV ASQEDTNCIL
110 120 130 140 150
LRSVSSNVSV DKEQKLSKCR DEDGCILETL YCSGCSLSLG YVYRCTPKNL
160 170 180 190 200
DYKRNLFCLS VEAVESYTLG SSEQQIVSEE EFFNLESRVE IEKSIKQMED
210 220
VLTVMQAKLW EVESKLSKAG RYS
Length:223
Mass (Da):25,216
Last modified:July 1, 2008 - v1
Checksum:iD7CFCC75AEFF990E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167102 mRNA. Translation: AAI67102.1.
RefSeqiNP_001120995.2. NM_001127523.2.
UniGeneiRn.137223.

Genome annotation databases

GeneIDi288272.
KEGGirno:288272.
UCSCiRGD:1310778. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167102 mRNA. Translation: AAI67102.1.
RefSeqiNP_001120995.2. NM_001127523.2.
UniGeneiRn.137223.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037080.

Proteomic databases

PaxDbiB2RZC4.
PRIDEiB2RZC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi288272.
KEGGirno:288272.
UCSCiRGD:1310778. rat.

Organism-specific databases

CTDi54069.
RGDi1310778. Mis18a.

Phylogenomic databases

eggNOGiENOG410IKYV. Eukaryota.
ENOG41125JV. LUCA.
HOGENOMiHOG000059535.
HOVERGENiHBG108147.
InParanoidiB2RZC4.
KOiK11564.
OMAiEDSSRHQ.
OrthoDBiEOG70KGSQ.
PhylomeDBiB2RZC4.
TreeFamiTF333200.

Enzyme and pathway databases

ReactomeiR-RNO-606279. Deposition of new CENPA-containing nucleosomes at the centromere.

Miscellaneous databases

NextBioi627882.
PROiB2RZC4.

Gene expression databases

GenevisibleiB2RZC4. RN.

Family and domain databases

InterProiIPR004910. Yippee/Mis18/Cereblon.
[Graphical view]
PfamiPF03226. Yippee-Mis18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMS18A_RAT
AccessioniPrimary (citable) accession number: B2RZC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: July 1, 2008
Last modified: May 11, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.