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Protein

Actin-related protein 2/3 complex subunit 4

Gene

Arpc4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-RNO-3928662. EPHB-mediated forward signaling.
R-RNO-5663213. RHO GTPases Activate WASPs and WAVEs.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 4UniRule annotation
Gene namesi
Name:Arpc4Imported
Synonyms:Arpc4_predictedImported
ORF Names:rCG_56555Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1310096. Arpc4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000008994.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiB2RZ72. 1 interactor.
MINTiMINT-7138173.
STRINGi10116.ENSRNOP00000011937.

Structurei

3D structure databases

SMRiB2RZ72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC4 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1876. Eukaryota.
ENOG4111G2F. LUCA.
GeneTreeiENSGT00390000016233.
HOGENOMiHOG000202303.
HOVERGENiHBG050582.
KOiK05755.
OMAiMLKHKIV.
OrthoDBiEOG091G0OI8.
TreeFamiTF105621.

Family and domain databases

Gene3Di3.30.1460.20. 1 hit.
InterProiView protein in InterPro
IPR034666. ARPC2/4.
IPR008384. ARPC4.
PANTHERiPTHR22629. PTHR22629. 1 hit.
PfamiView protein in Pfam
PF05856. ARPC4. 1 hit.
PIRSFiPIRSF039100. ARPC4. 1 hit.
SUPFAMiSSF69645. SSF69645. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RZ72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP
60 70 80 90 100
VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN
110 120 130 140 150
FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK
160
LSVNARARIV AEEFLKNF
Length:168
Mass (Da):19,667
Last modified:July 1, 2008 - v1
Checksum:i273CCB230AC703DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC183952 Genomic DNA. No translation available.
BC167049 mRNA. Translation: AAI67049.1.
CH473957 Genomic DNA. Translation: EDL91528.1.
RefSeqiNP_001100085.2. NM_001106615.2.
UniGeneiRn.198683.

Genome annotation databases

EnsembliENSRNOT00000011937; ENSRNOP00000011937; ENSRNOG00000008994.
GeneIDi297518.
KEGGirno:297518.
UCSCiRGD:1310096. rat.

Similar proteinsi

Entry informationi

Entry nameiB2RZ72_RAT
AccessioniPrimary (citable) accession number: B2RZ72
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 27, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported