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B2RZ59 (SH21A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2 domain-containing protein 1A
Gene names
Name:Sh2d1a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length126 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Ref.3

Subunit structure

Interacts with CD84, CD244, LY9, SLAMF1 and FYN By similarity. Interacts with NTRK1, NTRK2 and NTRK3. Ref.3

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 SH2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 126126SH2 domain-containing protein 1A
PRO_0000356885

Regions

Domain6 – 10297SH2

Amino acid modifications

Modified residue891N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RZ59 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 79BE17CC42049E6E

FASTA12613,992
        10         20         30         40         50         60 
MDAVTVYHGK ISREMGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY IYTYRVSQTE 

        70         80         90        100        110        120 
TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY PVEKSSARSP QAPTGRRDSD 


ICLKAP 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[3]"SLAM-associated protein as a potential negative regulator in Trk signaling."
Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN NTRK2 SIGNALING, INTERACTION WITH NTRK1; NTRK2 AND NTRK3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC167036 mRNA. Translation: AAI67036.1.
CH473991 Genomic DNA. Translation: EDM10890.1.
RefSeqNP_001102783.2. NM_001109313.2.
UniGeneRn.12605.

3D structure databases

ProteinModelPortalB2RZ59.
SMRB2RZ59. Positions 1-107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008444.

PTM databases

PhosphoSiteB2RZ59.

Proteomic databases

PRIDEB2RZ59.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneID501502.
KEGGrno:501502.
UCSCRGD:1562408. rat.

Organism-specific databases

CTD4068.
RGD1562408. Sh2d1a.

Phylogenomic databases

eggNOGNOG298713.
GeneTreeENSGT00510000046904.
HOGENOMHOG000231700.
HOVERGENHBG003702.
KOK07990.
OMAQGIAMPL.
OrthoDBEOG72VH86.
TreeFamTF343096.

Gene expression databases

GenevestigatorB2RZ59.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR017289. SH2_prot_1A.
[Graphical view]
PfamPF00017. SH2. 1 hit.
[Graphical view]
PIRSFPIRSF037828. SH2_p1A. 1 hit.
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
[Graphical view]
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio709046.
PROB2RZ59.

Entry information

Entry nameSH21A_RAT
AccessionPrimary (citable) accession number: B2RZ59
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families