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Protein

SH2 domain-containing protein 1A

Gene

Sh2d1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (PubMed:16223723).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 1A
Gene namesi
Name:Sh2d1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1562408. Sh2d1a.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003568851 – 126SH2 domain-containing protein 1AAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89N6-acetyllysineBy similarity1
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiB2RZ59.
PRIDEiB2RZ59.

PTM databases

iPTMnetiB2RZ59.
PhosphoSitePlusiB2RZ59.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006263.

Interactioni

Subunit structurei

Interacts with CD84, CD244, LY9, SLAMF1 and FYN (By similarity). Interacts with NTRK1, NTRK2 and NTRK3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008444.

Structurei

3D structure databases

ProteinModelPortaliB2RZ59.
SMRiB2RZ59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 102SH2PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 92Interaction with FYN SH3 domainBy similarityAdd BLAST26

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00510000046904.
HOGENOMiHOG000231700.
HOVERGENiHBG003702.
InParanoidiB2RZ59.
KOiK07990.
OMAiCLCVLCK.
OrthoDBiEOG091G0ULG.
PhylomeDBiB2RZ59.
TreeFamiTF343096.

Family and domain databases

CDDicd10400. SH2_SAP1a. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
IPR017289. SH2_prot_1A.
IPR035876. SH2D1A_SH2.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PIRSFiPIRSF037828. SH2_p1A. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RZ59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVTVYHGK ISREMGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY
60 70 80 90 100
IYTYRVSQTE TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY
110 120
PVEKSSARSP QAPTGRRDSD ICLKAP
Length:126
Mass (Da):13,992
Last modified:July 1, 2008 - v1
Checksum:i79BE17CC42049E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167036 mRNA. Translation: AAI67036.1.
CH473991 Genomic DNA. Translation: EDM10890.1.
RefSeqiNP_001102783.2. NM_001109313.2.
XP_008771750.1. XM_008773528.2.
UniGeneiRn.12605.

Genome annotation databases

EnsembliENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneIDi501502.
KEGGirno:501502.
UCSCiRGD:1562408. rat.

Similar proteinsi

Entry informationi

Entry nameiSH21A_RAT
AccessioniPrimary (citable) accession number: B2RZ59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: September 27, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome