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B2RZ59

- SH21A_RAT

UniProt

B2RZ59 - SH21A_RAT

Protein

SH2 domain-containing protein 1A

Gene

Sh2d1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.1 Publication

    GO - Biological processi

    1. cell-cell signaling Source: Ensembl
    2. cellular defense response Source: InterPro
    3. humoral immune response Source: Ensembl
    4. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
    5. positive regulation of signal transduction Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH2 domain-containing protein 1A
    Gene namesi
    Name:Sh2d1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi1562408. Sh2d1a.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126126SH2 domain-containing protein 1APRO_0000356885Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 891N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiB2RZ59.

    PTM databases

    PhosphoSiteiB2RZ59.

    Expressioni

    Gene expression databases

    GenevestigatoriB2RZ59.

    Interactioni

    Subunit structurei

    Interacts with CD84, CD244, LY9, SLAMF1 and FYN By similarity. Interacts with NTRK1, NTRK2 and NTRK3.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008444.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RZ59.
    SMRiB2RZ59. Positions 1-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 10297SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG298713.
    GeneTreeiENSGT00510000046904.
    HOGENOMiHOG000231700.
    HOVERGENiHBG003702.
    KOiK07990.
    OMAiQGIAMPL.
    OrthoDBiEOG72VH86.
    PhylomeDBiB2RZ59.
    TreeFamiTF343096.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR017289. SH2_prot_1A.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037828. SH2_p1A. 1 hit.
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RZ59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAVTVYHGK ISREMGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY    50
    IYTYRVSQTE TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY 100
    PVEKSSARSP QAPTGRRDSD ICLKAP 126
    Length:126
    Mass (Da):13,992
    Last modified:July 1, 2008 - v1
    Checksum:i79BE17CC42049E6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC167036 mRNA. Translation: AAI67036.1.
    CH473991 Genomic DNA. Translation: EDM10890.1.
    RefSeqiNP_001102783.2. NM_001109313.2.
    UniGeneiRn.12605.

    Genome annotation databases

    EnsembliENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
    GeneIDi501502.
    KEGGirno:501502.
    UCSCiRGD:1562408. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC167036 mRNA. Translation: AAI67036.1 .
    CH473991 Genomic DNA. Translation: EDM10890.1 .
    RefSeqi NP_001102783.2. NM_001109313.2.
    UniGenei Rn.12605.

    3D structure databases

    ProteinModelPortali B2RZ59.
    SMRi B2RZ59. Positions 1-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008444.

    PTM databases

    PhosphoSitei B2RZ59.

    Proteomic databases

    PRIDEi B2RZ59.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008444 ; ENSRNOP00000008444 ; ENSRNOG00000006263 .
    GeneIDi 501502.
    KEGGi rno:501502.
    UCSCi RGD:1562408. rat.

    Organism-specific databases

    CTDi 4068.
    RGDi 1562408. Sh2d1a.

    Phylogenomic databases

    eggNOGi NOG298713.
    GeneTreei ENSGT00510000046904.
    HOGENOMi HOG000231700.
    HOVERGENi HBG003702.
    KOi K07990.
    OMAi QGIAMPL.
    OrthoDBi EOG72VH86.
    PhylomeDBi B2RZ59.
    TreeFami TF343096.

    Miscellaneous databases

    NextBioi 709046.
    PROi B2RZ59.

    Gene expression databases

    Genevestigatori B2RZ59.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR017289. SH2_prot_1A.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037828. SH2_p1A. 1 hit.
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    3. "SLAM-associated protein as a potential negative regulator in Trk signaling."
      Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
      J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NTRK2 SIGNALING, INTERACTION WITH NTRK1; NTRK2 AND NTRK3.

    Entry informationi

    Entry nameiSH21A_RAT
    AccessioniPrimary (citable) accession number: B2RZ59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3