B2RZ59 (SH21A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH2 domain-containing protein 1A

Gene names

Name:

Sh2d1a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Ref.3
Subunit structure	Interacts with CD84, CD244, LY9, SLAMF1 and FYN By similarity. Interacts with NTRK1, NTRK2 and NTRK3. Ref.3
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 SH2 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	SH2 domain
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Inferred from electronic annotation. Source: Compara cellular defense response Inferred from electronic annotation. Source: InterPro humoral immune response Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 126	126	SH2 domain-containing protein 1A		PRO_0000356885
Regions
	Domain	6 – 102	97	SH2
Amino acid modifications
	Modified residue	89	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B2RZ59 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 79BE17CC42049E6E	FASTA	126	13,992
	10 20 30 40 50 60 MDAVTVYHGK ISREMGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY IYTYRVSQTE 70 80 90 100 110 120 TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY PVEKSSARSP QAPTGRRDSD ICLKAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus.
[3]	"SLAM-associated protein as a potential negative regulator in Trk signaling." Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y. J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN NTRK2 SIGNALING, INTERACTION WITH NTRK1; NTRK2 AND NTRK3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC167036 mRNA. Translation: AAI67036.1. CH473991 Genomic DNA. Translation: EDM10890.1.
IPI	IPI00187907.
RefSeq	NP_001102783.2. NM_001109313.2.
UniGene	Rn.12605.
3D structure databases
ProteinModelPortal	B2RZ59.
SMR	B2RZ59. Positions 1-107.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000008444.
PTM databases
PhosphoSite	B2RZ59.
Proteomic databases
PRIDE	B2RZ59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneID	501502.
KEGG	rno:501502.
UCSC	RGD:1562408. rat.
Organism-specific databases
CTD	4068.
RGD	1562408. Sh2d1a.
Phylogenomic databases
eggNOG	NOG298713.
GeneTree	ENSGT00510000046904.
HOGENOM	HOG000231700.
HOVERGEN	HBG003702.
KO	K07990.
OMA	TQGTTGR.
OrthoDB	EOG4HHP3S.
Gene expression databases
Genevestigator	B2RZ59.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. IPR017289. SH2_prot_1A. [Graphical view]
PANTHER	PTHR11200:SF1. PTHR11200:SF1. 1 hit.
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PIRSF	PIRSF037828. SH2_p1A. 1 hit.
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	709046.

Entry information

Entry name

SH21A_RAT

Accession

Primary (citable) accession number: B2RZ59

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	July 1, 2008
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program