Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SH2 domain-containing protein 1A

Gene

Sh2d1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.1 Publication

GO - Biological processi

  1. cell-cell signaling Source: InterPro
  2. cellular defense response Source: InterPro
  3. humoral immune response Source: Ensembl
  4. positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
  5. positive regulation of signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 1A
Gene namesi
Name:Sh2d1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi1562408. Sh2d1a.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126SH2 domain-containing protein 1APRO_0000356885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiB2RZ59.

PTM databases

PhosphoSiteiB2RZ59.

Expressioni

Gene expression databases

GenevestigatoriB2RZ59.

Interactioni

Subunit structurei

Interacts with CD84, CD244, LY9, SLAMF1 and FYN (By similarity). Interacts with NTRK1, NTRK2 and NTRK3.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008444.

Structurei

3D structure databases

ProteinModelPortaliB2RZ59.
SMRiB2RZ59. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10297SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG298713.
GeneTreeiENSGT00510000046904.
HOGENOMiHOG000231700.
HOVERGENiHBG003702.
InParanoidiB2RZ59.
KOiK07990.
OMAiCLCVLHQ.
OrthoDBiEOG72VH86.
PhylomeDBiB2RZ59.
TreeFamiTF343096.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR017289. SH2_prot_1A.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF037828. SH2_p1A. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RZ59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVTVYHGK ISREMGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY
60 70 80 90 100
IYTYRVSQTE TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY
110 120
PVEKSSARSP QAPTGRRDSD ICLKAP
Length:126
Mass (Da):13,992
Last modified:July 1, 2008 - v1
Checksum:i79BE17CC42049E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167036 mRNA. Translation: AAI67036.1.
CH473991 Genomic DNA. Translation: EDM10890.1.
RefSeqiNP_001102783.2. NM_001109313.2.
XP_008771750.1. XM_008773528.1.
UniGeneiRn.12605.

Genome annotation databases

EnsembliENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneIDi501502.
KEGGirno:501502.
UCSCiRGD:1562408. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167036 mRNA. Translation: AAI67036.1.
CH473991 Genomic DNA. Translation: EDM10890.1.
RefSeqiNP_001102783.2. NM_001109313.2.
XP_008771750.1. XM_008773528.1.
UniGeneiRn.12605.

3D structure databases

ProteinModelPortaliB2RZ59.
SMRiB2RZ59. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008444.

PTM databases

PhosphoSiteiB2RZ59.

Proteomic databases

PRIDEiB2RZ59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneIDi501502.
KEGGirno:501502.
UCSCiRGD:1562408. rat.

Organism-specific databases

CTDi4068.
RGDi1562408. Sh2d1a.

Phylogenomic databases

eggNOGiNOG298713.
GeneTreeiENSGT00510000046904.
HOGENOMiHOG000231700.
HOVERGENiHBG003702.
InParanoidiB2RZ59.
KOiK07990.
OMAiCLCVLHQ.
OrthoDBiEOG72VH86.
PhylomeDBiB2RZ59.
TreeFamiTF343096.

Miscellaneous databases

NextBioi709046.
PROiB2RZ59.

Gene expression databases

GenevestigatoriB2RZ59.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR017289. SH2_prot_1A.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF037828. SH2_p1A. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "SLAM-associated protein as a potential negative regulator in Trk signaling."
    Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
    J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NTRK2 SIGNALING, INTERACTION WITH NTRK1; NTRK2 AND NTRK3.

Entry informationi

Entry nameiSH21A_RAT
AccessioniPrimary (citable) accession number: B2RZ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: March 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.