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Protein

SH2 domain-containing protein 1A

Gene

Sh2d1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (PubMed:16223723).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 1A
Gene namesi
Name:Sh2d1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1562408. Sh2d1a.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126SH2 domain-containing protein 1APRO_0000356885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891N6-acetyllysineBy similarity
Modified residuei119 – 1191PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiB2RZ59.
PRIDEiB2RZ59.

PTM databases

iPTMnetiB2RZ59.
PhosphoSiteiB2RZ59.

Interactioni

Subunit structurei

Interacts with CD84, CD244, LY9, SLAMF1 and FYN (By similarity). Interacts with NTRK1, NTRK2 and NTRK3.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008444.

Structurei

3D structure databases

ProteinModelPortaliB2RZ59.
SMRiB2RZ59. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10297SH2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 9226Interaction with FYN SH3 domainBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00510000046904.
HOGENOMiHOG000231700.
HOVERGENiHBG003702.
InParanoidiB2RZ59.
KOiK07990.
OMAiCLCVLCK.
OrthoDBiEOG72VH86.
PhylomeDBiB2RZ59.
TreeFamiTF343096.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR017289. SH2_prot_1A.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF037828. SH2_p1A. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RZ59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVTVYHGK ISREMGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY
60 70 80 90 100
IYTYRVSQTE TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY
110 120
PVEKSSARSP QAPTGRRDSD ICLKAP
Length:126
Mass (Da):13,992
Last modified:July 1, 2008 - v1
Checksum:i79BE17CC42049E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167036 mRNA. Translation: AAI67036.1.
CH473991 Genomic DNA. Translation: EDM10890.1.
RefSeqiNP_001102783.2. NM_001109313.2.
XP_008771750.1. XM_008773528.1.
UniGeneiRn.12605.

Genome annotation databases

EnsembliENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneIDi501502.
KEGGirno:501502.
UCSCiRGD:1562408. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167036 mRNA. Translation: AAI67036.1.
CH473991 Genomic DNA. Translation: EDM10890.1.
RefSeqiNP_001102783.2. NM_001109313.2.
XP_008771750.1. XM_008773528.1.
UniGeneiRn.12605.

3D structure databases

ProteinModelPortaliB2RZ59.
SMRiB2RZ59. Positions 1-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008444.

PTM databases

iPTMnetiB2RZ59.
PhosphoSiteiB2RZ59.

Proteomic databases

PaxDbiB2RZ59.
PRIDEiB2RZ59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008444; ENSRNOP00000008444; ENSRNOG00000006263.
GeneIDi501502.
KEGGirno:501502.
UCSCiRGD:1562408. rat.

Organism-specific databases

CTDi4068.
RGDi1562408. Sh2d1a.

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00510000046904.
HOGENOMiHOG000231700.
HOVERGENiHBG003702.
InParanoidiB2RZ59.
KOiK07990.
OMAiCLCVLCK.
OrthoDBiEOG72VH86.
PhylomeDBiB2RZ59.
TreeFamiTF343096.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiB2RZ59.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR017289. SH2_prot_1A.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF037828. SH2_p1A. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "SLAM-associated protein as a potential negative regulator in Trk signaling."
    Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y.
    J. Biol. Chem. 280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NTRK2 SIGNALING, INTERACTION WITH NTRK1; NTRK2 AND NTRK3.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSH21A_RAT
AccessioniPrimary (citable) accession number: B2RZ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.