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B2RZ50

- CDKN3_RAT

UniProt

B2RZ50 - CDKN3_RAT

Protein

Cyclin-dependent kinase inhibitor 3

Gene

Cdkn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei140 – 1401Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein serine/threonine phosphatase activity Source: Ensembl
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase inhibitor 3By similarity (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    CDK2-associated dual-specificity phosphataseBy similarity
    Kinase-associated phosphataseBy similarity
    Gene namesi
    Name:Cdkn3Imported
    Synonyms:KapBy similarity
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi1307781. Cdkn3.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Cyclin-dependent kinase inhibitor 3PRO_0000396639Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriB2RZ50.

    Interactioni

    Subunit structurei

    Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012985.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RZ50.
    SMRiB2RZ50. Positions 21-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3434Interaction with CDK2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein-tyrosine phosphatase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00390000004717.
    HOGENOMiHOG000060336.
    HOVERGENiHBG075798.
    KOiK14167.
    OMAiTVKQYNF.
    OrthoDBiEOG7M0NSV.
    PhylomeDBiB2RZ50.
    TreeFamiTF101040.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR008425. CDK_inhib_3.
    IPR022778. CDKN3.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
    PfamiPF05706. CDKN3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037322. CDKN3. 1 hit.
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RZ50-1 [UniParc]FASTAAdd to Basket

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    MKPPISIQAS EFDSSDEEPA DDEQTPIQIS WLPLSRVNCS QFLGLCALPG    50
    CKFKDVRRNI QKDTEELKSS GIQDVFVFCT RGELSKYRVP NLLDLYQQYG 100
    IVTHHHPIPD GGTPDIGSCW EIMEELATCL KNNRKTLIHC YGGLGRSCLV 150
    AACLLLYLSD SISPQQAIDS LRDVRGSGAI QTIKQYNYLH EFRDKLAAYL 200
    SSRDSLSRSV SR 212
    Length:212
    Mass (Da):23,774
    Last modified:July 1, 2008 - v1
    Checksum:i345F42838AA50801
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474040 Genomic DNA. Translation: EDL88327.1.
    BC167026 mRNA. Translation: AAI67026.1.
    RefSeqiXP_006251853.1. XM_006251791.1.
    UniGeneiRn.229034.

    Genome annotation databases

    EnsembliENSRNOT00000012985; ENSRNOP00000012985; ENSRNOG00000009785.
    GeneIDi289993.
    KEGGirno:289993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474040 Genomic DNA. Translation: EDL88327.1 .
    BC167026 mRNA. Translation: AAI67026.1 .
    RefSeqi XP_006251853.1. XM_006251791.1.
    UniGenei Rn.229034.

    3D structure databases

    ProteinModelPortali B2RZ50.
    SMRi B2RZ50. Positions 21-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012985.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012985 ; ENSRNOP00000012985 ; ENSRNOG00000009785 .
    GeneIDi 289993.
    KEGGi rno:289993.

    Organism-specific databases

    CTDi 1033.
    RGDi 1307781. Cdkn3.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00390000004717.
    HOGENOMi HOG000060336.
    HOVERGENi HBG075798.
    KOi K14167.
    OMAi TVKQYNF.
    OrthoDBi EOG7M0NSV.
    PhylomeDBi B2RZ50.
    TreeFami TF101040.

    Gene expression databases

    Genevestigatori B2RZ50.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR008425. CDK_inhib_3.
    IPR022778. CDKN3.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR23339:SF24. PTHR23339:SF24. 1 hit.
    Pfami PF05706. CDKN3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037322. CDKN3. 1 hit.
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown Norway/NHsdMcwi1 Publication.
      Tissue: Embryonic liverImported.

    Entry informationi

    Entry nameiCDKN3_RAT
    AccessioniPrimary (citable) accession number: B2RZ50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3