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B2RZ50 (CDKN3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase inhibitor 3

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
CDK2-associated dual-specificity phosphatase
Kinase-associated phosphatase
Gene names
Name:Cdkn3
Synonyms:Kap
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner By similarity. UniProtKB Q16667

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q16667

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity By similarity. UniProtKB Q16667

Subcellular location

Cytoplasmperinuclear region By similarity UniProtKB Q16667.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle arrest

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentperinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprotein serine/threonine phosphatase activity

Inferred from electronic annotation. Source: Ensembl

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Cyclin-dependent kinase inhibitor 3
PRO_0000396639

Regions

Region1 – 3434Interaction with CDK2 By similarity UniProtKB Q16667

Sites

Active site1401Phosphocysteine intermediate By similarity UniProtKB Q16667

Sequences

Sequence LengthMass (Da)Tools
B2RZ50 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: 345F42838AA50801

FASTA21223,774
        10         20         30         40         50         60 
MKPPISIQAS EFDSSDEEPA DDEQTPIQIS WLPLSRVNCS QFLGLCALPG CKFKDVRRNI 

        70         80         90        100        110        120 
QKDTEELKSS GIQDVFVFCT RGELSKYRVP NLLDLYQQYG IVTHHHPIPD GGTPDIGSCW 

       130        140        150        160        170        180 
EIMEELATCL KNNRKTLIHC YGGLGRSCLV AACLLLYLSD SISPQQAIDS LRDVRGSGAI 

       190        200        210 
QTIKQYNYLH EFRDKLAAYL SSRDSLSRSV SR 

« Hide

References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Brown Norway/NHsdMcwi.
Tissue: Embryonic liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH474040 Genomic DNA. Translation: EDL88327.1.
BC167026 mRNA. Translation: AAI67026.1.
RefSeqXP_006251853.1. XM_006251791.1.
UniGeneRn.229034.

3D structure databases

ProteinModelPortalB2RZ50.
SMRB2RZ50. Positions 21-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012985.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012985; ENSRNOP00000012985; ENSRNOG00000009785.
GeneID289993.
KEGGrno:289993.

Organism-specific databases

CTD1033.
RGD1307781. Cdkn3.

Phylogenomic databases

eggNOGCOG2453.
GeneTreeENSGT00390000004717.
HOGENOMHOG000060336.
HOVERGENHBG075798.
KOK14167.
OMATVKQYNF.
OrthoDBEOG7M0NSV.
PhylomeDBB2RZ50.
TreeFamTF101040.

Gene expression databases

GenevestigatorB2RZ50.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFPIRSF037322. CDKN3. 1 hit.
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDKN3_RAT
AccessionPrimary (citable) accession number: B2RZ50
Entry history
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families