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Protein

Cyclin-dependent kinase inhibitor 3

Gene

Cdkn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: Ensembl
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle arrest Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3By similarity (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphataseBy similarity
Kinase-associated phosphataseBy similarity
Gene namesi
Name:Cdkn3Imported
Synonyms:KapBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1307781. Cdkn3.

Subcellular locationi

Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Cyclin-dependent kinase inhibitor 3PRO_0000396639Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriB2RZ50.

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012985.

Structurei

3D structure databases

ProteinModelPortaliB2RZ50.
SMRiB2RZ50. Positions 21-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3434Interaction with CDK2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00390000004717.
HOGENOMiHOG000060336.
HOVERGENiHBG075798.
InParanoidiB2RZ50.
KOiK14167.
OMAiTVKQYNF.
OrthoDBiEOG7M0NSV.
PhylomeDBiB2RZ50.
TreeFamiTF101040.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamiPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFiPIRSF037322. CDKN3. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RZ50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPISIQAS EFDSSDEEPA DDEQTPIQIS WLPLSRVNCS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNI QKDTEELKSS GIQDVFVFCT RGELSKYRVP NLLDLYQQYG
110 120 130 140 150
IVTHHHPIPD GGTPDIGSCW EIMEELATCL KNNRKTLIHC YGGLGRSCLV
160 170 180 190 200
AACLLLYLSD SISPQQAIDS LRDVRGSGAI QTIKQYNYLH EFRDKLAAYL
210
SSRDSLSRSV SR
Length:212
Mass (Da):23,774
Last modified:July 1, 2008 - v1
Checksum:i345F42838AA50801
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474040 Genomic DNA. Translation: EDL88327.1.
BC167026 mRNA. Translation: AAI67026.1.
RefSeqiXP_006251853.1. XM_006251791.2.
UniGeneiRn.229034.

Genome annotation databases

EnsembliENSRNOT00000012985; ENSRNOP00000012985; ENSRNOG00000009785.
GeneIDi289993.
KEGGirno:289993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474040 Genomic DNA. Translation: EDL88327.1.
BC167026 mRNA. Translation: AAI67026.1.
RefSeqiXP_006251853.1. XM_006251791.2.
UniGeneiRn.229034.

3D structure databases

ProteinModelPortaliB2RZ50.
SMRiB2RZ50. Positions 21-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012985; ENSRNOP00000012985; ENSRNOG00000009785.
GeneIDi289993.
KEGGirno:289993.

Organism-specific databases

CTDi1033.
RGDi1307781. Cdkn3.

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00390000004717.
HOGENOMiHOG000060336.
HOVERGENiHBG075798.
InParanoidiB2RZ50.
KOiK14167.
OMAiTVKQYNF.
OrthoDBiEOG7M0NSV.
PhylomeDBiB2RZ50.
TreeFamiTF101040.

Gene expression databases

GenevestigatoriB2RZ50.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR008425. CDK_inhib_3.
IPR022778. CDKN3.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR23339:SF24. PTHR23339:SF24. 1 hit.
PfamiPF05706. CDKN3. 1 hit.
[Graphical view]
PIRSFiPIRSF037322. CDKN3. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway/NHsdMcwi1 Publication.
    Tissue: Embryonic liverImported.

Entry informationi

Entry nameiCDKN3_RAT
AccessioniPrimary (citable) accession number: B2RZ50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 1, 2008
Last modified: January 7, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.