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B2RZ17 (FBXW2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box/WD repeat-containing protein 2
Alternative name(s):
F-box and WD-40 domain-containing protein 2
Protein MD6
Gene names
Name:Fbxw2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity. UniProtKB Q9UKT8

Subunit structure

Directly interacts with SKP1 and CUL1 By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 4 WD repeats.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   DomainRepeat
WD repeat
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454F-box/WD repeat-containing protein 2
PRO_0000391377

Regions

Domain54 – 10148F-box
Repeat146 – 18338WD 1
Repeat185 – 22137WD 2
Repeat224 – 26542WD 3
Repeat276 – 31439WD 4

Amino acid modifications

Modified residue2981N6-acetyllysine By similarity UniProtKB Q9UKT8

Sequences

Sequence LengthMass (Da)Tools
B2RZ17 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: FFF540F2CC34453A

FASTA45451,408
        10         20         30         40         50         60 
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL 

        70         80         90        100        110        120 
PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK 

       130        140        150        160        170        180 
KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC 

       190        200        210        220        230        240 
VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI 

       250        260        270        280        290        300 
LVSGSADFAV KVWALSAGTC LNTLTGHTEW VTKVVLQQCK VKSLLHSPGD YILLSADKYE 

       310        320        330        340        350        360 
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW DFASYDILRV 

       370        380        390        400        410        420 
IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR WPLPEYRKSK RGSSFLAGEA 

       430        440        450 
SWLNGLDGHN DTGLVFATSM PDHSIHLVLW KEHG 

« Hide

References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Brown Norway.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH474001 Genomic DNA. Translation: EDL93165.1.
CH474001 Genomic DNA. Translation: EDL93166.1.
BC166990 mRNA. Translation: AAI66990.1.
RefSeqNP_001101305.1. NM_001107835.2.
XP_006234039.1. XM_006233977.1.
XP_006234040.1. XM_006233978.1.
UniGeneRn.103250.

3D structure databases

ProteinModelPortalB2RZ17.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025399.

Proteomic databases

PaxDbB2RZ17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025399; ENSRNOP00000025399; ENSRNOG00000018687.
GeneID311881.
KEGGrno:311881.
UCSCRGD:1310460. rat.

Organism-specific databases

CTD26190.
RGD1310460. Fbxw2.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00710000106459.
HOGENOMHOG000231971.
HOVERGENHBG051593.
KOK10261.
OMAQTHTCAT.
OrthoDBEOG7PS1F6.
TreeFamTF333134.

Gene expression databases

GenevestigatorB2RZ17.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 4 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio664403.
PROB2RZ17.

Entry information

Entry nameFBXW2_RAT
AccessionPrimary (citable) accession number: B2RZ17
Entry history
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: July 1, 2008
Last modified: March 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families