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B2RZ17

- FBXW2_RAT

UniProt

B2RZ17 - FBXW2_RAT

Protein

F-box/WD repeat-containing protein 2

Gene

Fbxw2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/WD repeat-containing protein 2
    Alternative name(s):
    F-box and WD-40 domain-containing protein 2Imported
    Protein MD6By similarity
    Gene namesi
    Name:Fbxw2Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1310460. Fbxw2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454F-box/WD repeat-containing protein 2PRO_0000391377Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei298 – 2981N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiB2RZ17.

    Expressioni

    Gene expression databases

    GenevestigatoriB2RZ17.

    Interactioni

    Subunit structurei

    Directly interacts with SKP1 and CUL1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025399.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RZ17.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 10148F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati146 – 18338WD 1Sequence AnalysisAdd
    BLAST
    Repeati185 – 22137WD 2Sequence AnalysisAdd
    BLAST
    Repeati224 – 26542WD 3Sequence AnalysisAdd
    BLAST
    Repeati276 – 31439WD 4Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00710000106459.
    HOGENOMiHOG000231971.
    HOVERGENiHBG051593.
    KOiK10261.
    OMAiQTHTCAT.
    OrthoDBiEOG7PS1F6.
    PhylomeDBiB2RZ17.
    TreeFamiTF333134.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF00400. WD40. 4 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00256. FBOX. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RZ17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET    50
    LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT 100
    ACKNLGWQID DSVQDALHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR 150
    VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV 200
    TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI LVSGSADFAV 250
    KVWALSAGTC LNTLTGHTEW VTKVVLQQCK VKSLLHSPGD YILLSADKYE 300
    IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW 350
    DFASYDILRV IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR 400
    WPLPEYRKSK RGSSFLAGEA SWLNGLDGHN DTGLVFATSM PDHSIHLVLW 450
    KEHG 454
    Length:454
    Mass (Da):51,408
    Last modified:July 1, 2008 - v1
    Checksum:iFFF540F2CC34453A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474001 Genomic DNA. Translation: EDL93165.1.
    CH474001 Genomic DNA. Translation: EDL93166.1.
    BC166990 mRNA. Translation: AAI66990.1.
    RefSeqiNP_001101305.1. NM_001107835.2.
    XP_006234039.1. XM_006233977.1.
    XP_006234040.1. XM_006233978.1.
    UniGeneiRn.103250.

    Genome annotation databases

    EnsembliENSRNOT00000025399; ENSRNOP00000025399; ENSRNOG00000018687.
    GeneIDi311881.
    KEGGirno:311881.
    UCSCiRGD:1310460. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474001 Genomic DNA. Translation: EDL93165.1 .
    CH474001 Genomic DNA. Translation: EDL93166.1 .
    BC166990 mRNA. Translation: AAI66990.1 .
    RefSeqi NP_001101305.1. NM_001107835.2.
    XP_006234039.1. XM_006233977.1.
    XP_006234040.1. XM_006233978.1.
    UniGenei Rn.103250.

    3D structure databases

    ProteinModelPortali B2RZ17.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025399.

    Proteomic databases

    PaxDbi B2RZ17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025399 ; ENSRNOP00000025399 ; ENSRNOG00000018687 .
    GeneIDi 311881.
    KEGGi rno:311881.
    UCSCi RGD:1310460. rat.

    Organism-specific databases

    CTDi 26190.
    RGDi 1310460. Fbxw2.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00710000106459.
    HOGENOMi HOG000231971.
    HOVERGENi HBG051593.
    KOi K10261.
    OMAi QTHTCAT.
    OrthoDBi EOG7PS1F6.
    PhylomeDBi B2RZ17.
    TreeFami TF333134.

    Miscellaneous databases

    NextBioi 664403.
    PROi B2RZ17.

    Gene expression databases

    Genevestigatori B2RZ17.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR001810. F-box_dom.
    IPR020472. G-protein_beta_WD-40_rep.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF00400. WD40. 4 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00256. FBOX. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown NorwayImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiFBXW2_RAT
    AccessioniPrimary (citable) accession number: B2RZ17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 9, 2010
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3