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B2RZ17

- FBXW2_RAT

UniProt

B2RZ17 - FBXW2_RAT

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Protein

F-box/WD repeat-containing protein 2

Gene

Fbxw2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 2
Alternative name(s):
F-box and WD-40 domain-containing protein 2Imported
Protein MD6By similarity
Gene namesi
Name:Fbxw2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1310460. Fbxw2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454F-box/WD repeat-containing protein 2PRO_0000391377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei298 – 2981N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB2RZ17.

Expressioni

Gene expression databases

GenevestigatoriB2RZ17.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025399.

Structurei

3D structure databases

ProteinModelPortaliB2RZ17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 10148F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati146 – 18338WD 1Sequence AnalysisAdd
BLAST
Repeati185 – 22137WD 2Sequence AnalysisAdd
BLAST
Repeati224 – 26542WD 3Sequence AnalysisAdd
BLAST
Repeati276 – 31439WD 4Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000231971.
HOVERGENiHBG051593.
InParanoidiB2RZ17.
KOiK10261.
OMAiQTHTCAT.
OrthoDBiEOG7PS1F6.
PhylomeDBiB2RZ17.
TreeFamiTF333134.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RZ17 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET
60 70 80 90 100
LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT
110 120 130 140 150
ACKNLGWQID DSVQDALHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR
160 170 180 190 200
VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV
210 220 230 240 250
TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI LVSGSADFAV
260 270 280 290 300
KVWALSAGTC LNTLTGHTEW VTKVVLQQCK VKSLLHSPGD YILLSADKYE
310 320 330 340 350
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW
360 370 380 390 400
DFASYDILRV IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR
410 420 430 440 450
WPLPEYRKSK RGSSFLAGEA SWLNGLDGHN DTGLVFATSM PDHSIHLVLW

KEHG
Length:454
Mass (Da):51,408
Last modified:July 1, 2008 - v1
Checksum:iFFF540F2CC34453A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474001 Genomic DNA. Translation: EDL93165.1.
CH474001 Genomic DNA. Translation: EDL93166.1.
BC166990 mRNA. Translation: AAI66990.1.
RefSeqiNP_001101305.1. NM_001107835.2.
XP_006234039.1. XM_006233977.2.
UniGeneiRn.103250.

Genome annotation databases

EnsembliENSRNOT00000025399; ENSRNOP00000025399; ENSRNOG00000018687.
GeneIDi311881.
KEGGirno:311881.
UCSCiRGD:1310460. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474001 Genomic DNA. Translation: EDL93165.1 .
CH474001 Genomic DNA. Translation: EDL93166.1 .
BC166990 mRNA. Translation: AAI66990.1 .
RefSeqi NP_001101305.1. NM_001107835.2.
XP_006234039.1. XM_006233977.2.
UniGenei Rn.103250.

3D structure databases

ProteinModelPortali B2RZ17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025399.

Proteomic databases

PaxDbi B2RZ17.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025399 ; ENSRNOP00000025399 ; ENSRNOG00000018687 .
GeneIDi 311881.
KEGGi rno:311881.
UCSCi RGD:1310460. rat.

Organism-specific databases

CTDi 26190.
RGDi 1310460. Fbxw2.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119106.
HOGENOMi HOG000231971.
HOVERGENi HBG051593.
InParanoidi B2RZ17.
KOi K10261.
OMAi QTHTCAT.
OrthoDBi EOG7PS1F6.
PhylomeDBi B2RZ17.
TreeFami TF333134.

Miscellaneous databases

NextBioi 664403.
PROi B2RZ17.

Gene expression databases

Genevestigatori B2RZ17.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00256. FBOX. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown NorwayImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiFBXW2_RAT
AccessioniPrimary (citable) accession number: B2RZ17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3