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Protein

F-box/WD repeat-containing protein 2

Gene

Fbxw2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-8951664 Neddylation
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 2
Alternative name(s):
F-box and WD-40 domain-containing protein 2Imported
Protein MD6By similarity
Gene namesi
Name:Fbxw2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1310460 Fbxw2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003913771 – 454F-box/WD repeat-containing protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB2RZ17
PeptideAtlasiB2RZ17
PRIDEiB2RZ17

PTM databases

iPTMnetiB2RZ17
PhosphoSitePlusiB2RZ17

Expressioni

Gene expression databases

BgeeiENSRNOG00000018687
GenevisibleiB2RZ17 RN

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025399

Structurei

3D structure databases

ProteinModelPortaliB2RZ17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 101F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati146 – 183WD 1Sequence analysisAdd BLAST38
Repeati185 – 221WD 2Sequence analysisAdd BLAST37
Repeati224 – 265WD 3Sequence analysisAdd BLAST42
Repeati276 – 314WD 4Sequence analysisAdd BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
GeneTreeiENSGT00910000144137
HOGENOMiHOG000231971
HOVERGENiHBG051593
InParanoidiB2RZ17
KOiK10261
OMAiQTHTCAT
OrthoDBiEOG091G060Z
PhylomeDBiB2RZ17
TreeFamiTF333134

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

B2RZ17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET
60 70 80 90 100
LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT
110 120 130 140 150
ACKNLGWQID DSVQDALHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR
160 170 180 190 200
VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV
210 220 230 240 250
TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI LVSGSADFAV
260 270 280 290 300
KVWALSAGTC LNTLTGHTEW VTKVVLQQCK VKSLLHSPGD YILLSADKYE
310 320 330 340 350
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW
360 370 380 390 400
DFASYDILRV IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR
410 420 430 440 450
WPLPEYRKSK RGSSFLAGEA SWLNGLDGHN DTGLVFATSM PDHSIHLVLW

KEHG
Length:454
Mass (Da):51,408
Last modified:July 1, 2008 - v1
Checksum:iFFF540F2CC34453A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474001 Genomic DNA Translation: EDL93165.1
CH474001 Genomic DNA Translation: EDL93166.1
BC166990 mRNA Translation: AAI66990.1
RefSeqiNP_001101305.1, NM_001107835.2
XP_006234039.1, XM_006233977.3
XP_008759973.1, XM_008761751.2
XP_008759974.1, XM_008761752.2
UniGeneiRn.103250

Genome annotation databases

EnsembliENSRNOT00000025399; ENSRNOP00000025399; ENSRNOG00000018687
GeneIDi311881
KEGGirno:311881
UCSCiRGD:1310460 rat

Similar proteinsi

Entry informationi

Entry nameiFBXW2_RAT
AccessioniPrimary (citable) accession number: B2RZ17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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