Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-tubulin complex component

Gene

Tubgcp2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, IntegrinImported, MetalloproteaseImported, Protease

Enzyme and pathway databases

ReactomeiR-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex componentUniRule annotation
Gene namesi
Name:Tubgcp2Imported
Synonyms:Adam8_predictedImported
ORF Names:rCG_47540Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309597. Tubgcp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation, MicrotubuleUniRule annotation

Interactioni

Protein-protein interaction databases

MINTiMINT-7138097.
STRINGi10116.ENSRNOP00000024573.

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2001. Eukaryota.
ENOG410XNRE. LUCA.
GeneTreeiENSGT00840000129807.
HOGENOMiHOG000273895.
HOVERGENiHBG026103.
KOiK16569.
OMAiSMINIIY.
OrthoDBiEOG7FFMR6.
TreeFamiTF324047.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 3 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RYP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEFRIHHDV NELLSLLRIH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK
60 70 80 90 100
VKIAEFSRTP EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ
110 120 130 140 150
NAKERAELAA SAAASSATGF SIPVAASKMS TQELEELRKQ LGSVATGSTL
160 170 180 190 200
QQSLELTRKM LRDKQNKKNS GQPLPVFPAW VYERPTLAGD FLIGSGLSSD
210 220 230 240 250
TTLPIGTLPL ASQESAVVED LLYVLVGVDG RYITAQPLAG RQNRTFLVDP
260 270 280 290 300
NLDLSIRELV NRILPVAASY STVTRFIEEK SSFEYGQVNH ALAAAMRTLV
310 320 330 340 350
KEYLILVTQL EQLHRQGLLS LQKLWFYIQP AMRTIDILAS LATSVDKGEC
360 370 380 390 400
VGGSTLSLLH DRSFNYTGDS QAQELCLYLT KAASAPYFEI LEEWIYRGVI
410 420 430 440 450
HDPYSEFMVE EHELRKEKIQ EDYNDKYWDQ RYTVLPQQIP SFLQKVAGKI
460 470 480 490 500
LSTGKYLNVV RECGHDVTCP VAKEIIYTLK ERAYVEQIEK AFNYASKVLL
510 520 530 540 550
DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLTEEELR KPVEDITPTR
560 570 580 590 600
LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM
610 620 630 640 650
THADPTELTL SGLEAFSFDY MVKWPLSLII NRKALTRYQM LFRHMFYCKH
660 670 680 690 700
VERQLCSVWI SNKTAKQHAL HSAKWFAGAF TLRQRMLNFV QNIQYYMMFE
710 720 730 740 750
VMEPTWHILE KNLKSASNID DVLGHHTSFL DNCLKDCMLT NPELLKVFSK
760 770 780 790 800
LMSVCVMFTN CMQKFTQSMK LDSELGRLTL DQGSVQGPPP ESERIDDRPR
810 820 830 840 850
KEPTRKHLPE HVDTPQLSSG FEATINNFDK NFSAHLLDLL ARLSVYSTSD
860 870 880 890 900
CEHGMASVIS RLDFNGFYAE RLERLSAERS QKAAPQVPVP RGPPAPASRV

AIPAQ
Length:905
Mass (Da):103,060
Last modified:July 1, 2008 - v1
Checksum:i268714988ED9D9F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005988 Genomic DNA. No translation available.
BC166857 mRNA. Translation: AAI66857.1.
CH473953 Genomic DNA. Translation: EDM11868.1.
RefSeqiNP_001101030.1. NM_001107560.2.
XP_006230519.1. XM_006230457.1.
XP_006230520.1. XM_006230458.1.
XP_006230521.1. XM_006230459.2.
XP_006230522.1. XM_006230460.1.
UniGeneiRn.138249.

Genome annotation databases

EnsembliENSRNOT00000024573; ENSRNOP00000024573; ENSRNOG00000018137.
GeneIDi309098.
KEGGirno:309098.
UCSCiRGD:1309597. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005988 Genomic DNA. No translation available.
BC166857 mRNA. Translation: AAI66857.1.
CH473953 Genomic DNA. Translation: EDM11868.1.
RefSeqiNP_001101030.1. NM_001107560.2.
XP_006230519.1. XM_006230457.1.
XP_006230520.1. XM_006230458.1.
XP_006230521.1. XM_006230459.2.
XP_006230522.1. XM_006230460.1.
UniGeneiRn.138249.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-7138097.
STRINGi10116.ENSRNOP00000024573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024573; ENSRNOP00000024573; ENSRNOG00000018137.
GeneIDi309098.
KEGGirno:309098.
UCSCiRGD:1309597. rat.

Organism-specific databases

CTDi10844.
RGDi1309597. Tubgcp2.

Phylogenomic databases

eggNOGiKOG2001. Eukaryota.
ENOG410XNRE. LUCA.
GeneTreeiENSGT00840000129807.
HOGENOMiHOG000273895.
HOVERGENiHBG026103.
KOiK16569.
OMAiSMINIIY.
OrthoDBiEOG7FFMR6.
TreeFamiTF324047.

Enzyme and pathway databases

ReactomeiR-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

NextBioi660116.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 3 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SpleenImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB2RYP8_RAT
AccessioniPrimary (citable) accession number: B2RYP8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.