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B2RYN2 (FBX31_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 31
Gene names
Name:Fbxo31
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Post-translational modification

Phosphorylation by ATM following gamma-irradiation results in its stabilization By similarity.

Sequence similarities

Belongs to the FBXO31 family.

Contains 1 F-box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507F-box only protein 31
PRO_0000349261

Regions

Domain50 – 9647F-box

Amino acid modifications

Modified residue331Phosphoserine By similarity
Modified residue371Phosphothreonine By similarity
Modified residue2641Phosphoserine; by ATM By similarity

Sequences

Sequence LengthMass (Da)Tools
B2RYN2 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: B4AEE043B0F9FD20

FASTA50757,399
        10         20         30         40         50         60 
MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR CSLLELPPEL 

        70         80         90        100        110        120 
LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE YGVCENLRKL EITGVSCRDV 

       130        140        150        160        170        180 
YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI 

       190        200        210        220        230        240 
HLMERKSATV ECMYGHKGPH NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW 

       250        260        270        280        290        300 
GRTLEDIFHE HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL 

       310        320        330        340        350        360 
EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN ELSRIVLEVR 

       370        380        390        400        410        420 
EQVRQEQEAG EGPAPHREPA VKDPEGPPAK ASKEAGPGAE AAEQSSTSGQ GQPFVLPAGV 

       430        440        450        460        470        480 
SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV 

       490        500 
QATFQNADAP SPQAFDEMLR NIQSLTS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC166840 mRNA. Translation: AAI66840.1.
RefSeqNP_001037724.2. NM_001044259.2.
UniGeneRn.163412.

3D structure databases

ProteinModelPortalB2RYN2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000063581.

Proteomic databases

PRIDEB2RYN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000068764; ENSRNOP00000063581; ENSRNOG00000042274.
GeneID498959.
KEGGrno:498959.
UCSCRGD:1561069. rat.

Organism-specific databases

CTD79791.
RGD1561069. Fbxo31.

Phylogenomic databases

eggNOGNOG43393.
GeneTreeENSGT00390000001368.
HOVERGENHBG071549.
KOK10308.
OMAPERTPGV.
PhylomeDBB2RYN2.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorB2RYN2.

Family and domain databases

InterProIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERPTHR10706:SF121. PTHR10706:SF121. 1 hit.
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF81383. SSF81383. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio701387.

Entry information

Entry nameFBX31_RAT
AccessionPrimary (citable) accession number: B2RYN2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways