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B2RYN2

- FBX31_RAT

UniProt

B2RYN2 - FBX31_RAT

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Protein

F-box only protein 31

Gene
Fbxo31
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.

Pathwayi

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: UniProtKB
  2. cyclin catabolic process Source: UniProtKB
  3. mitotic G1 DNA damage checkpoint Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB-UniPathway
  5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31
Gene namesi
Name:Fbxo31
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi1561069. Fbxo31.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507F-box only protein 31PRO_0000349261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Phosphoserine By similarity
Modified residuei37 – 371Phosphothreonine By similarity
Modified residuei264 – 2641Phosphoserine; by ATM By similarity

Post-translational modificationi

Phosphorylation by ATM following gamma-irradiation results in its stabilization By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB2RYN2.

Expressioni

Gene expression databases

GenevestigatoriB2RYN2.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063581.

Structurei

3D structure databases

ProteinModelPortaliB2RYN2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 9647F-boxAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.
Contains 1 F-box domain.

Phylogenomic databases

eggNOGiNOG43393.
GeneTreeiENSGT00390000001368.
HOVERGENiHBG071549.
KOiK10308.
OMAiPERTPGV.
PhylomeDBiB2RYN2.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RYN2-1 [UniParc]FASTAAdd to Basket

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MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR    50
CSLLELPPEL LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE 100
YGVCENLRKL EITGVSCRDV YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV 150
DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI HLMERKSATV ECMYGHKGPH 200
NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW GRTLEDIFHE 250
HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL 300
EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN 350
ELSRIVLEVR EQVRQEQEAG EGPAPHREPA VKDPEGPPAK ASKEAGPGAE 400
AAEQSSTSGQ GQPFVLPAGV SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE 450
RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV QATFQNADAP SPQAFDEMLR 500
NIQSLTS 507
Length:507
Mass (Da):57,399
Last modified:July 1, 2008 - v1
Checksum:iB4AEE043B0F9FD20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166840 mRNA. Translation: AAI66840.1.
RefSeqiNP_001037724.2. NM_001044259.2.
UniGeneiRn.163412.

Genome annotation databases

EnsembliENSRNOT00000068764; ENSRNOP00000063581; ENSRNOG00000042274.
GeneIDi498959.
KEGGirno:498959.
UCSCiRGD:1561069. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166840 mRNA. Translation: AAI66840.1 .
RefSeqi NP_001037724.2. NM_001044259.2.
UniGenei Rn.163412.

3D structure databases

ProteinModelPortali B2RYN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000063581.

Proteomic databases

PRIDEi B2RYN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068764 ; ENSRNOP00000063581 ; ENSRNOG00000042274 .
GeneIDi 498959.
KEGGi rno:498959.
UCSCi RGD:1561069. rat.

Organism-specific databases

CTDi 79791.
RGDi 1561069. Fbxo31.

Phylogenomic databases

eggNOGi NOG43393.
GeneTreei ENSGT00390000001368.
HOVERGENi HBG071549.
KOi K10308.
OMAi PERTPGV.
PhylomeDBi B2RYN2.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 701387.

Gene expression databases

Genevestigatori B2RYN2.

Family and domain databases

InterProi IPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view ]
PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
Pfami PF12937. F-box-like. 1 hit.
[Graphical view ]
SMARTi SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF81383. SSF81383. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiFBX31_RAT
AccessioniPrimary (citable) accession number: B2RYN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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