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Protein

F-box only protein 31

Gene

Fbxo31

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).By similarity

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 31
Gene namesi
Name:Fbxo31
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1561069. Fbxo31.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: CACAO
  • neuronal cell body Source: UniProtKB
  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507F-box only protein 31PRO_0000349261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei37 – 371PhosphothreonineBy similarity
Modified residuei264 – 2641Phosphoserine; by ATMBy similarity

Post-translational modificationi

Phosphorylation by ATM following gamma-irradiation results in its stabilization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB2RYN2.

Expressioni

Gene expression databases

ExpressionAtlasiB2RYN2. baseline.
GenevisibleiB2RYN2. RN.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063581.

Structurei

3D structure databases

ProteinModelPortaliB2RYN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 9647F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FBXO31 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG43393.
GeneTreeiENSGT00390000001368.
HOVERGENiHBG071549.
InParanoidiB2RYN2.
KOiK10308.
OMAiPQAFDEM.
PhylomeDBiB2RYN2.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RYN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR
60 70 80 90 100
CSLLELPPEL LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE
110 120 130 140 150
YGVCENLRKL EITGVSCRDV YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV
160 170 180 190 200
DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI HLMERKSATV ECMYGHKGPH
210 220 230 240 250
NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW GRTLEDIFHE
260 270 280 290 300
HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL
310 320 330 340 350
EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN
360 370 380 390 400
ELSRIVLEVR EQVRQEQEAG EGPAPHREPA VKDPEGPPAK ASKEAGPGAE
410 420 430 440 450
AAEQSSTSGQ GQPFVLPAGV SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE
460 470 480 490 500
RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV QATFQNADAP SPQAFDEMLR

NIQSLTS
Length:507
Mass (Da):57,399
Last modified:July 1, 2008 - v1
Checksum:iB4AEE043B0F9FD20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166840 mRNA. Translation: AAI66840.1.
RefSeqiNP_001037724.2. NM_001044259.2.
UniGeneiRn.163412.

Genome annotation databases

EnsembliENSRNOT00000068764; ENSRNOP00000063581; ENSRNOG00000042274.
GeneIDi498959.
KEGGirno:498959.
UCSCiRGD:1561069. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166840 mRNA. Translation: AAI66840.1.
RefSeqiNP_001037724.2. NM_001044259.2.
UniGeneiRn.163412.

3D structure databases

ProteinModelPortaliB2RYN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063581.

Proteomic databases

PRIDEiB2RYN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068764; ENSRNOP00000063581; ENSRNOG00000042274.
GeneIDi498959.
KEGGirno:498959.
UCSCiRGD:1561069. rat.

Organism-specific databases

CTDi79791.
RGDi1561069. Fbxo31.

Phylogenomic databases

eggNOGiNOG43393.
GeneTreeiENSGT00390000001368.
HOVERGENiHBG071549.
InParanoidiB2RYN2.
KOiK10308.
OMAiPQAFDEM.
PhylomeDBiB2RYN2.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi701387.
PROiB2RYN2.

Gene expression databases

ExpressionAtlasiB2RYN2. baseline.
GenevisibleiB2RYN2. RN.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR026941. FBXO31.
[Graphical view]
PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiFBX31_RAT
AccessioniPrimary (citable) accession number: B2RYN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 1, 2008
Last modified: June 24, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.