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B2RYN2

- FBX31_RAT

UniProt

B2RYN2 - FBX31_RAT

Protein

F-box only protein 31

Gene

Fbxo31

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest By similarity.By similarity

    Pathwayi

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB
    2. cyclin catabolic process Source: UniProtKB
    3. mitotic G1 DNA damage checkpoint Source: UniProtKB
    4. protein ubiquitination Source: UniProtKB-UniPathway
    5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, DNA damage, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 31
    Gene namesi
    Name:Fbxo31
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi1561069. Fbxo31.

    Subcellular locationi

    GO - Cellular componenti

    1. SCF ubiquitin ligase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507F-box only protein 31PRO_0000349261Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331PhosphoserineBy similarity
    Modified residuei37 – 371PhosphothreonineBy similarity
    Modified residuei264 – 2641Phosphoserine; by ATMBy similarity

    Post-translational modificationi

    Phosphorylation by ATM following gamma-irradiation results in its stabilization.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiB2RYN2.

    Expressioni

    Gene expression databases

    GenevestigatoriB2RYN2.

    Interactioni

    Subunit structurei

    Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000063581.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RYN2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 9647F-boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FBXO31 family.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG43393.
    GeneTreeiENSGT00390000001368.
    HOVERGENiHBG071549.
    KOiK10308.
    OMAiPERTPGV.
    PhylomeDBiB2RYN2.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR026941. FBXO31.
    [Graphical view]
    PANTHERiPTHR10706:SF126. PTHR10706:SF126. 1 hit.
    PfamiPF12937. F-box-like. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF81383. SSF81383. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RYN2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVCARLCGV GPARGCRRRQ QRRGPAETAA ADSEADTDPE EERIEAGPAR    50
    CSLLELPPEL LVEIFASLPG TDLPSLAQVC SRFRRILHTD TIWRRRCREE 100
    YGVCENLRKL EITGVSCRDV YAKLLHRYRH ILGLWQPDIG PYGGLLNVVV 150
    DGLFIIGWMY LPPHDPHVGD PMRFKPLFRI HLMERKSATV ECMYGHKGPH 200
    NGHIQIVKRD EFSTKCNQTD HHRMSGGRQE EFRTWLREEW GRTLEDIFHE 250
    HMQELILMKF IYTSQYDNCL TYRRIYLPPS HPDDLIKPGL FKGTYGSHGL 300
    EIVMLSFHGS RARGTKITGD PNIPAGQQTV EIDLQRRIQL PDVENLRNFN 350
    ELSRIVLEVR EQVRQEQEAG EGPAPHREPA VKDPEGPPAK ASKEAGPGAE 400
    AAEQSSTSGQ GQPFVLPAGV SSRNEDYPRT CRLCFYGTGL IAGHGFTSPE 450
    RTPGVFVLFD EDRFGFLWLE LKSFSLYSRV QATFQNADAP SPQAFDEMLR 500
    NIQSLTS 507
    Length:507
    Mass (Da):57,399
    Last modified:July 1, 2008 - v1
    Checksum:iB4AEE043B0F9FD20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166840 mRNA. Translation: AAI66840.1.
    RefSeqiNP_001037724.2. NM_001044259.2.
    UniGeneiRn.163412.

    Genome annotation databases

    EnsembliENSRNOT00000068764; ENSRNOP00000063581; ENSRNOG00000042274.
    GeneIDi498959.
    KEGGirno:498959.
    UCSCiRGD:1561069. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC166840 mRNA. Translation: AAI66840.1 .
    RefSeqi NP_001037724.2. NM_001044259.2.
    UniGenei Rn.163412.

    3D structure databases

    ProteinModelPortali B2RYN2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000063581.

    Proteomic databases

    PRIDEi B2RYN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068764 ; ENSRNOP00000063581 ; ENSRNOG00000042274 .
    GeneIDi 498959.
    KEGGi rno:498959.
    UCSCi RGD:1561069. rat.

    Organism-specific databases

    CTDi 79791.
    RGDi 1561069. Fbxo31.

    Phylogenomic databases

    eggNOGi NOG43393.
    GeneTreei ENSGT00390000001368.
    HOVERGENi HBG071549.
    KOi K10308.
    OMAi PERTPGV.
    PhylomeDBi B2RYN2.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 701387.

    Gene expression databases

    Genevestigatori B2RYN2.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR026941. FBXO31.
    [Graphical view ]
    PANTHERi PTHR10706:SF126. PTHR10706:SF126. 1 hit.
    Pfami PF12937. F-box-like. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81383. SSF81383. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiFBX31_RAT
    AccessioniPrimary (citable) accession number: B2RYN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3