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B2RYJ9

- B2RYJ9_RAT

UniProt

B2RYJ9 - B2RYJ9_RAT

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Protein
Submitted name:

Eps8l2 protein

Gene

Eps8l2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Rac guanyl-nucleotide exchange factor activity Source: Ensembl

GO - Biological processi

  1. positive regulation of ruffle assembly Source: Ensembl
  2. regulation of Rac GTPase activity Source: Ensembl
  3. Rho protein signal transduction Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Eps8l2 proteinImported
Gene namesi
Name:Eps8l2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1310912. Eps8l2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. protein complex Source: Ensembl
  4. ruffle membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB2RYJ9.

Expressioni

Gene expression databases

ExpressionAtlasiB2RYJ9. baseline and differential.
GenevestigatoriB2RYJ9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024725.

Structurei

3D structure databases

ProteinModelPortaliB2RYJ9.
SMRiB2RYJ9. Positions 498-552, 615-700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiNOG263108.
HOGENOMiHOG000060324.
HOVERGENiHBG003090.
KOiK17277.
PhylomeDBiB2RYJ9.
TreeFamiTF313069.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RYJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQSANMSCC PGAANGSLGR SDGVPRMSAK DLFEQRKKYS NSNVIMHETS
60 70 80 90 100
QYHVQHLATF IMDKSEAIAT VDDAIRKLVQ LSSKEKVWAQ EVLLQVNDKS
110 120 130 140 150
LRLLDVESQE ELENFPLPTV QHSQTVLNQL RYPSVLLLVC QDSDQNKPDI
160 170 180 190 200
HFFHCDEVEA DLVQEDIESA LADYRLGKKM RPQTLKGHQE KIRQRQSILP
210 220 230 240 250
PPQSPAPIPF QRQPGDSPQA KNRVGLPLPA SFSEPGYRRR ESQDEEPRAV
260 270 280 290 300
LAQRIEKETQ ILNCTLDDIE WFVARLQKAA EAFKQLNQRK KGKKKNKKGP
310 320 330 340 350
AEGVLTLRAR PPTEGEFVDC FQKTKLAINL LAKLQKHIQN PSAAELVHFL
360 370 380 390 400
FGPLDLIINT CGGPDLARSV SSPLLSTDAV SFLRGHLVPK EMTLWESLGE
410 420 430 440 450
TWMRPRSEWP REPQVPLYVP KFRSGWEPPL DVLQEAPWEI EGLTSVPSDQ
460 470 480 490 500
LNPKSRLSVR HSPKHSLSSE PQVPEDVAPP GSSPHANRGY HPTPAMTKYV
510 520 530 540 550
KILYDFTARN ANELSVLKDE VLEVLEDGRQ WWKLRNRSGQ AGYVPCNILA
560 570 580 590 600
EARQEDVGAP LEQSGQKYWG PASPTHKLPP IFAGNKEELI HHMDEVNDEL
610 620 630 640 650
MKKISHIKTQ PQRNFRVERS QPVHLPLTFE SGPEEVRAWL EAKAFSGRIV
660 670 680 690 700
ENLGILTGPQ LFSLNKEELK KVCGEEGSRV YSQLTVQKSF LEKQQSGSEL
710 720
EKLMNKIRRA EDSYSNVHTS PEAEGAPHL
Length:729
Mass (Da):82,276
Last modified:July 1, 2008 - v1
Checksum:i55FE51234E319FDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166805 mRNA. Translation: AAI66805.1.
RefSeqiXP_006230624.1. XM_006230562.1.
UniGeneiRn.23793.

Genome annotation databases

GeneIDi361674.
KEGGirno:361674.
UCSCiRGD:1310912. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC166805 mRNA. Translation: AAI66805.1 .
RefSeqi XP_006230624.1. XM_006230562.1.
UniGenei Rn.23793.

3D structure databases

ProteinModelPortali B2RYJ9.
SMRi B2RYJ9. Positions 498-552, 615-700.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000024725.

Proteomic databases

PRIDEi B2RYJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 361674.
KEGGi rno:361674.
UCSCi RGD:1310912. rat.

Organism-specific databases

CTDi 64787.
RGDi 1310912. Eps8l2.

Phylogenomic databases

eggNOGi NOG263108.
HOGENOMi HOG000060324.
HOVERGENi HBG003090.
KOi K17277.
PhylomeDBi B2RYJ9.
TreeFami TF313069.

Miscellaneous databases

NextBioi 35565012.
PROi B2RYJ9.

Gene expression databases

ExpressionAtlasi B2RYJ9. baseline and differential.
Genevestigatori B2RYJ9.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR013625. PTB.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF08416. PTB. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: ProstateImported.

Entry informationi

Entry nameiB2RYJ9_RAT
AccessioniPrimary (citable) accession number: B2RYJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)