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Protein

Epithelial splicing regulatory protein 2

Gene

Esrp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 2
Alternative name(s):
RNA-binding motif protein 35B
RNA-binding protein 35B
Gene namesi
Name:Esrp2
Synonyms:Rbm35b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310855. Esrp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003706321 – 716Epithelial splicing regulatory protein 2Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei562PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RYJ8.
PeptideAtlasiB2RYJ8.
PRIDEiB2RYJ8.

PTM databases

iPTMnetiB2RYJ8.
PhosphoSitePlusiB2RYJ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023177.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026873.

Structurei

3D structure databases

ProteinModelPortaliB2RYJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 342RRM 1Add BLAST97
Domaini347 – 427RRM 2Add BLAST81
Domaini464 – 544RRM 3Add BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 27Pro-richAdd BLAST25

Sequence similaritiesi

Belongs to the ESRP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
HOGENOMiHOG000112401.
InParanoidiB2RYJ8.
PhylomeDBiB2RYJ8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 3 hits.

Sequencei

Sequence statusi: Complete.

B2RYJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPPPPPPP PGPDPAVDSS TDPCPEPQSL VVLFGATAGA LGPDLGSDET
60 70 80 90 100
DLILLVWQVV EPRSRQVGTL HKSLVRAEAA ALSPQCREAS GLSADSLARA
110 120 130 140 150
ESLDKVLQQF SQLVSGDVAL LGGGPYVLCT DGQQLLRQVL HPEASRKNLV
160 170 180 190 200
LPDTFFSFYD LRREFHVQHP STCSARDLTV GTMAQDLGLE TDATEDDFGV
210 220 230 240 250
WEVKTMVAVI LHLLEGPNGH LFSKPEVVKQ KYETGPCKAD VVDNETVVRA
260 270 280 290 300
RGLPWQSSDQ DVARFFKGLN IARGGVALCL NAQGRRNGEA LIRFEDSEQR
310 320 330 340 350
DLALQRHKHH MGVRYIEVYK ATGEEFVKIA GGTSLEVARF LSREDQVILR
360 370 380 390 400
LRGLPFSAGP ADVLDFLGPE CPVTGGVDGL LFVRHPDGRP TGDAFALFAC
410 420 430 440 450
EELAQAALRR HKGMLGKRYI ELFRSTAAEV QQVLNRYAAS PLLPTLTAPL
460 470 480 490 500
LPIPFPLAGG TGRDCVRLRG LPYTATIEDI LSFLGEAAAD IRPHGVHMVL
510 520 530 540 550
NQQGRPSGDA FIQMMSVERA LAAAQRCHKK VMKERYVEVV PCSTEEMSRV
560 570 580 590 600
LMGGSLSRSG LSPPPCKLPC LSPPTYATFQ ASPALIPTET TALYPSSALL
610 620 630 640 650
PAARVPAAAT PLAYYPGPAT QLYMNYTAYY PSPPVSPTTV GYLTTPPTAL
660 670 680 690 700
ASTPTSMLSQ PGALVRMQGV PYTAGMKDLL SVFQAYQLAP DDYATLVPVG
710
DPPRTVLQAP KEWVCL
Length:716
Mass (Da):77,241
Last modified:July 1, 2008 - v1
Checksum:iF90DBDED49172796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166804 mRNA. Translation: AAI66804.1.
RefSeqiXP_006255558.1. XM_006255496.3.
UniGeneiRn.137974.

Genome annotation databases

GeneIDi307810.
UCSCiRGD:1310855. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166804 mRNA. Translation: AAI66804.1.
RefSeqiXP_006255558.1. XM_006255496.3.
UniGeneiRn.137974.

3D structure databases

ProteinModelPortaliB2RYJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026873.

PTM databases

iPTMnetiB2RYJ8.
PhosphoSitePlusiB2RYJ8.

Proteomic databases

PaxDbiB2RYJ8.
PeptideAtlasiB2RYJ8.
PRIDEiB2RYJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi307810.
UCSCiRGD:1310855. rat.

Organism-specific databases

CTDi80004.
RGDi1310855. Esrp2.

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
HOGENOMiHOG000112401.
InParanoidiB2RYJ8.
PhylomeDBiB2RYJ8.

Miscellaneous databases

PROiB2RYJ8.

Gene expression databases

BgeeiENSRNOG00000023177.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiESRP2_RAT
AccessioniPrimary (citable) accession number: B2RYJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.