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Protein

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Gene

Aasdhppt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN (By similarity).By similarity

Catalytic activityi

CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei47 – 471Coenzyme ABy similarity
Metal bindingi129 – 1291MagnesiumBy similarity
Metal bindingi181 – 1811MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-199220. Vitamin B5 (pantothenate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC:2.7.8.-)
Alternative name(s):
4'-phosphopantetheinyl transferase
Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
Short name:
AASD-PPT
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1311360. Aasdhppt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferasePRO_0000379130Add
BLAST

Proteomic databases

PaxDbiB2RYJ4.
PeptideAtlasiB2RYJ4.
PRIDEiB2RYJ4.

PTM databases

iPTMnetiB2RYJ4.
PhosphoSiteiB2RYJ4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005795.
GenevisibleiB2RYJ4. RN.

Interactioni

Subunit structurei

Monomer. Interacts with FASN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008062.

Structurei

3D structure databases

ProteinModelPortaliB2RYJ4.
SMRiB2RYJ4. Positions 13-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 916Coenzyme A bindingBy similarity
Regioni108 – 1114Coenzyme A bindingBy similarity
Regioni181 – 1855Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0945. Eukaryota.
COG2091. LUCA.
GeneTreeiENSGT00390000004663.
HOGENOMiHOG000265195.
InParanoidiB2RYJ4.
KOiK06133.
OMAiVRWAFRC.
OrthoDBiEOG091G0CU8.
PhylomeDBiB2RYJ4.
TreeFamiTF313753.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
SUPFAMiSSF56214. SSF56214. 2 hits.

Sequencei

Sequence statusi: Complete.

B2RYJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPAKRLCV VPYMEGVRWA FSCGTWLPSP AEWLLAVRSI QPEEKERIGQ
60 70 80 90 100
FVFARDAKAA LAGRLMIRKL VAEKLNIPWD HIRLQRTSKG KPILAKDTLN
110 120 130 140 150
PYPNFNFNIS HQGDYTVLAA EPELQVGIDI MKTSFPGRGS IPEFFHIMKR
160 170 180 190 200
KFTNKEWETI RSFNDEWSQL DMFYRHWALK ESFIKAIGVG LGFEMQRLEF
210 220 230 240 250
DVSPLSMDIG QVYKETRLIL DGEEEKEWAF EESKIDQHHF VAVALRKPDG
260 270 280 290 300
SRHQNVSYQD DSKPSQRQFT ILNFNDLIAS AIPMTPEDPS FWDCFCFTEE

ILIRNGSKS
Length:309
Mass (Da):35,816
Last modified:July 1, 2008 - v1
Checksum:i8E35E6BA4BB13620
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474089 Genomic DNA. Translation: EDL85225.1.
BC166800 mRNA. Translation: AAI66800.1.
RefSeqiNP_001100268.2. NM_001106798.2.
UniGeneiRn.17217.

Genome annotation databases

EnsembliENSRNOT00000008062; ENSRNOP00000008062; ENSRNOG00000005795.
GeneIDi300328.
KEGGirno:300328.
UCSCiRGD:1311360. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474089 Genomic DNA. Translation: EDL85225.1.
BC166800 mRNA. Translation: AAI66800.1.
RefSeqiNP_001100268.2. NM_001106798.2.
UniGeneiRn.17217.

3D structure databases

ProteinModelPortaliB2RYJ4.
SMRiB2RYJ4. Positions 13-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008062.

PTM databases

iPTMnetiB2RYJ4.
PhosphoSiteiB2RYJ4.

Proteomic databases

PaxDbiB2RYJ4.
PeptideAtlasiB2RYJ4.
PRIDEiB2RYJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008062; ENSRNOP00000008062; ENSRNOG00000005795.
GeneIDi300328.
KEGGirno:300328.
UCSCiRGD:1311360. rat.

Organism-specific databases

CTDi60496.
RGDi1311360. Aasdhppt.

Phylogenomic databases

eggNOGiKOG0945. Eukaryota.
COG2091. LUCA.
GeneTreeiENSGT00390000004663.
HOGENOMiHOG000265195.
InParanoidiB2RYJ4.
KOiK06133.
OMAiVRWAFRC.
OrthoDBiEOG091G0CU8.
PhylomeDBiB2RYJ4.
TreeFamiTF313753.

Enzyme and pathway databases

ReactomeiR-RNO-199220. Vitamin B5 (pantothenate) metabolism.

Miscellaneous databases

PROiB2RYJ4.

Gene expression databases

BgeeiENSRNOG00000005795.
GenevisibleiB2RYJ4. RN.

Family and domain databases

Gene3Di3.90.470.20. 2 hits.
InterProiIPR008278. 4-PPantetheinyl_Trfase_SF.
[Graphical view]
PfamiPF01648. ACPS. 1 hit.
[Graphical view]
SUPFAMiSSF56214. SSF56214. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiADPPT_RAT
AccessioniPrimary (citable) accession number: B2RYJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.