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Protein

Docking protein 3

Gene

Dok3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 3
Alternative name(s):
Downstream of tyrosine kinase 3
Gene namesi
Name:Dok3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1311840. Dok3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562811 – 444Docking protein 3Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei138PhosphoserineBy similarity1
Modified residuei274PhosphoserineCombined sources1
Modified residuei308PhosphoserineBy similarity1
Modified residuei314PhosphoserineBy similarity1
Modified residuei325PhosphotyrosineBy similarity1
Modified residuei371PhosphoserineBy similarity1

Post-translational modificationi

Constitutively tyrosine-phosphorylated.By similarity
On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RYG7.
PeptideAtlasiB2RYG7.
PRIDEiB2RYG7.

PTM databases

iPTMnetiB2RYG7.
PhosphoSitePlusiB2RYG7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013564.
GenevisibleiB2RYG7. RN.

Interactioni

Subunit structurei

On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018232.

Structurei

3D structure databases

ProteinModelPortaliB2RYG7.
SMRiB2RYG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 123PHAdd BLAST117
Domaini157 – 261IRS-type PTBPROSITE-ProRule annotationAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 315Pro-richAdd BLAST78

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type A subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000112245.
HOVERGENiHBG051391.
InParanoidiB2RYG7.
OMAiKGPAPCD.
OrthoDBiEOG091G075T.
PhylomeDBiB2RYG7.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF02174. IRS. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS51064. IRS_PTB. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RYG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVETPVKD GLLYQQHMKF GKKCWRKVWA LLYAGGPSGV ARLESWDVRD
60 70 80 90 100
GGLGPGGDRP AGPGRRGERR IIRLADCVSV LPADGESCPR DTGAFLITTT
110 120 130 140 150
ERSHLLAAQH RQSWMDPICQ LAFPSTGECS SGSGQAESPK RGFVPMEENS
160 170 180 190 200
IYSSWQEVAE FPVVVQRTEA TTRCQLKGPY LLVLGQDDIQ LRETSKPQAC
210 220 230 240 250
YSWPYRFLRK FGSDKGVFSF EAGRRCDSGE GLFAFSSPRA PDICGAVAAA
260 270 280 290 300
IARQRERLPE LAMSPPCPLP RALSLPSLEP PGELREVAPE YELAPSRKLP
310 320 330 340 350
LTDPGPQSLP LLLSPTQDGT ASSLYASVCK QTSKHKATVE HLYENVFMLE
360 370 380 390 400
ASPGLSNGGP EAQEGPPGGR SPLGSPIYHN SEELSWPGSA HDSNLEAQYR
410 420 430 440
RLLELELDDA GGAGRPGAQT GIKAKLVTLL TRERKKGPAP CDRP
Length:444
Mass (Da):48,190
Last modified:July 1, 2008 - v1
Checksum:iDF79C5ADB1893046
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474032 Genomic DNA. Translation: EDL93971.1.
BC166772 mRNA. Translation: AAI66772.1.
RefSeqiNP_001100806.1. NM_001107336.1.
XP_006253681.1. XM_006253619.3.
UniGeneiRn.19911.

Genome annotation databases

EnsembliENSRNOT00000018232; ENSRNOP00000018232; ENSRNOG00000013564.
GeneIDi306760.
KEGGirno:306760.
UCSCiRGD:1311840. rat.

Similar proteinsi

Entry informationi

Entry nameiDOK3_RAT
AccessioniPrimary (citable) accession number: B2RYG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: September 27, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families