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Protein

Protein phosphatase 1 regulatory subunit 37

Gene

Ppp1r37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37
Alternative name(s):
Leucine-rich repeat-containing protein 68
Gene namesi
Name:Ppp1r37
Synonyms:Lrrc68
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1595870. Ppp1r37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Protein phosphatase 1 regulatory subunit 37PRO_0000398617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei581 – 5811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RYF1.
PeptideAtlasiB2RYF1.

PTM databases

iPTMnetiB2RYF1.
PhosphoSiteiB2RYF1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017692.
GenevisibleiB2RYF1. RN.

Interactioni

Subunit structurei

Interacts with PPP1CA.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB2RYF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati224 – 24421LRR 1Add
BLAST
Repeati252 – 27322LRR 2Add
BLAST
Repeati281 – 30121LRR 3Add
BLAST
Repeati310 – 33021LRR 4Add
BLAST
Repeati338 – 35821LRR 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi547 – 670124Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PPP1R37 family.Curated
Contains 5 LRR (leucine-rich) repeats.Sequence analysis

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiB2RYF1.
KOiK17576.
OMAiQLTHAGM.
OrthoDBiEOG091G0KU7.
PhylomeDBiB2RYF1.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RYF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPPQEAPP GPGADADADA EAEEAPAEAG SSSGASPPTD GRLKAAAKRV
60 70 80 90 100
TFPSDEDIVS GAVEPKDPWR HAQNVTVDEV ISAYRQACQK LNCRQIPKLL
110 120 130 140 150
RQLQEFTDLE QRINCLDLKG EKLDYKTCEA LEEVFKRLQF KVVDLEQTNL
160 170 180 190 200
DEDGASALFD MIEYYESATH LNISFNKHIG TRGWQAAAHM MRKTSCLQYL
210 220 230 240 250
DARNTPLLDH SAPFVARALR IRSSLAVLHL ENASLSGRPL MLLATALKMN
260 270 280 290 300
MNLQELYLAD NKLNGLQDSA QLGNLLKFNC SLQILDLRNN HVLDSGLAYI
310 320 330 340 350
CEGLKEQRKG LVTLVLWNNQ LTHTGMAFLG MALPHTQSLE TLNLGHNPIG
360 370 380 390 400
NEGVRNLKNG LISNRSVLRL GLASTKLTCE GAVAVAEFIA ESPRLLRLDL
410 420 430 440 450
RENEIKTGGL MALSLALKVN HSLLRLDLDR EPKKEPVKSF IETQKALLAE
460 470 480 490 500
IQNGCKRNFV LVREREEKQQ LQPSASMPEI TITAPQPLEE SGDLPAMGAQ
510 520 530 540 550
NGTPGPGPGP DSDSDSDSDR EEQEEEEEDQ SDQQRDEGGT DQSSSAPCPA
560 570 580 590 600
LLPSTDSLGP GDKSPPGSPS SPTEQRISVS SPGRGHKVFV VTRVESPPER
610 620 630 640 650
PEPPVPPTSV SSPPPSPPSP PASPPSQTMD TQDPESSEAQ PQTEPSQAGQ
660 670 680 690 700
PLPNGLKPEF ALALAPEAPP GLEAKGSSCS LEHALHRSHG VSKLEELLLE
710
ASQEAPRDTL
Length:710
Mass (Da):76,934
Last modified:July 1, 2008 - v1
Checksum:iCA92E638236BA23A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM08187.1.
BC166755 mRNA. Translation: AAI66755.1.
RefSeqiNP_001100952.1. NM_001107482.1.
UniGeneiRn.7032.

Genome annotation databases

EnsembliENSRNOT00000023867; ENSRNOP00000023866; ENSRNOG00000017692.
GeneIDi308398.
KEGGirno:308398.
UCSCiRGD:1595870. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM08187.1.
BC166755 mRNA. Translation: AAI66755.1.
RefSeqiNP_001100952.1. NM_001107482.1.
UniGeneiRn.7032.

3D structure databases

ProteinModelPortaliB2RYF1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB2RYF1.
PhosphoSiteiB2RYF1.

Proteomic databases

PaxDbiB2RYF1.
PeptideAtlasiB2RYF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023867; ENSRNOP00000023866; ENSRNOG00000017692.
GeneIDi308398.
KEGGirno:308398.
UCSCiRGD:1595870. rat.

Organism-specific databases

CTDi284352.
RGDi1595870. Ppp1r37.

Phylogenomic databases

eggNOGiKOG1908. Eukaryota.
ENOG410XSTR. LUCA.
GeneTreeiENSGT00730000111194.
HOGENOMiHOG000074153.
HOVERGENiHBG108102.
InParanoidiB2RYF1.
KOiK17576.
OMAiQLTHAGM.
OrthoDBiEOG091G0KU7.
PhylomeDBiB2RYF1.

Miscellaneous databases

PROiB2RYF1.

Gene expression databases

BgeeiENSRNOG00000017692.
GenevisibleiB2RYF1. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR37_RAT
AccessioniPrimary (citable) accession number: B2RYF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.