Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1 regulatory subunit 37

Gene

Ppp1r37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 37
Alternative name(s):
Leucine-rich repeat-containing protein 68
Gene namesi
Name:Ppp1r37
Synonyms:Lrrc68
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1595870 Ppp1r37

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986171 – 710Protein phosphatase 1 regulatory subunit 37Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RYF1
PeptideAtlasiB2RYF1
PRIDEiB2RYF1

PTM databases

CarbonylDBiB2RYF1
iPTMnetiB2RYF1
PhosphoSitePlusiB2RYF1

Expressioni

Gene expression databases

BgeeiENSRNOG00000017692
GenevisibleiB2RYF1 RN

Interactioni

Subunit structurei

Interacts with PPP1CA.By similarity

Structurei

3D structure databases

ProteinModelPortaliB2RYF1
SMRiB2RYF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati224 – 244LRR 1Add BLAST21
Repeati252 – 273LRR 2Add BLAST22
Repeati281 – 301LRR 3Add BLAST21
Repeati310 – 330LRR 4Add BLAST21
Repeati338 – 358LRR 5Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi547 – 670Pro-richSequence analysisAdd BLAST124

Sequence similaritiesi

Belongs to the PPP1R37 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG1908 Eukaryota
ENOG410XSTR LUCA
GeneTreeiENSGT00730000110609
HOGENOMiHOG000074153
HOVERGENiHBG108102
InParanoidiB2RYF1
KOiK17576
OMAiSFIETQR
OrthoDBiEOG091G0KU7
PhylomeDBiB2RYF1

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

B2RYF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPPQEAPP GPGADADADA EAEEAPAEAG SSSGASPPTD GRLKAAAKRV
60 70 80 90 100
TFPSDEDIVS GAVEPKDPWR HAQNVTVDEV ISAYRQACQK LNCRQIPKLL
110 120 130 140 150
RQLQEFTDLE QRINCLDLKG EKLDYKTCEA LEEVFKRLQF KVVDLEQTNL
160 170 180 190 200
DEDGASALFD MIEYYESATH LNISFNKHIG TRGWQAAAHM MRKTSCLQYL
210 220 230 240 250
DARNTPLLDH SAPFVARALR IRSSLAVLHL ENASLSGRPL MLLATALKMN
260 270 280 290 300
MNLQELYLAD NKLNGLQDSA QLGNLLKFNC SLQILDLRNN HVLDSGLAYI
310 320 330 340 350
CEGLKEQRKG LVTLVLWNNQ LTHTGMAFLG MALPHTQSLE TLNLGHNPIG
360 370 380 390 400
NEGVRNLKNG LISNRSVLRL GLASTKLTCE GAVAVAEFIA ESPRLLRLDL
410 420 430 440 450
RENEIKTGGL MALSLALKVN HSLLRLDLDR EPKKEPVKSF IETQKALLAE
460 470 480 490 500
IQNGCKRNFV LVREREEKQQ LQPSASMPEI TITAPQPLEE SGDLPAMGAQ
510 520 530 540 550
NGTPGPGPGP DSDSDSDSDR EEQEEEEEDQ SDQQRDEGGT DQSSSAPCPA
560 570 580 590 600
LLPSTDSLGP GDKSPPGSPS SPTEQRISVS SPGRGHKVFV VTRVESPPER
610 620 630 640 650
PEPPVPPTSV SSPPPSPPSP PASPPSQTMD TQDPESSEAQ PQTEPSQAGQ
660 670 680 690 700
PLPNGLKPEF ALALAPEAPP GLEAKGSSCS LEHALHRSHG VSKLEELLLE
710
ASQEAPRDTL
Length:710
Mass (Da):76,934
Last modified:July 1, 2008 - v1
Checksum:iCA92E638236BA23A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA Translation: EDM08187.1
BC166755 mRNA Translation: AAI66755.1
RefSeqiNP_001100952.1, NM_001107482.1
UniGeneiRn.7032

Genome annotation databases

EnsembliENSRNOT00000023867; ENSRNOP00000023866; ENSRNOG00000017692
GeneIDi308398
KEGGirno:308398
UCSCiRGD:1595870 rat

Similar proteinsi

Entry informationi

Entry nameiPPR37_RAT
AccessioniPrimary (citable) accession number: B2RYF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health