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Protein

Epithelial splicing regulatory protein 1

Gene

Esrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-6803529. FGFR2 alternative splicing.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 1
Alternative name(s):
RNA-binding motif protein 35A
RNA-binding protein 35A
Gene namesi
Name:Esrp1
Synonyms:Rbm35a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1560481. Esrp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 677677Epithelial splicing regulatory protein 1PRO_0000370631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei543 – 5431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RYD2.
PeptideAtlasiB2RYD2.

PTM databases

PhosphoSiteiB2RYD2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008184.
ExpressionAtlasiB2RYD2. baseline and differential.
GenevisibleiB2RYD2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010846.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 30278RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini326 – 40681RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini445 – 52581RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ESRP family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000112401.
InParanoidiB2RYD2.
KOiK14947.
PhylomeDBiB2RYD2.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RYD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTASPDYLVV LFGITAGATG AKLGSDEKEL ILLLWKVVDL ANKKVGQLHE
60 70 80 90 100
VLVRPDQLEL TEDCKEETKI DAENLSSAPQ LDQALRQFNQ SVSNELNIGV
110 120 130 140 150
GTSFCLCTDG QLHVRQILHP EASKKNVLLP ECFYSFFDLR KEFKKCCPGS
160 170 180 190 200
PDLDKLDVAA MAESLNFEKN DSMSRYGASQ VEDMGNIILA MISEPYNHRF
210 220 230 240 250
SDPERVNYKF ESGTCSKTEL IDGNTVVRAR GLPWQSSDQD IARFFKGLNI
260 270 280 290 300
AKGGAALCLN AQGRRNGEAL VRFVSEEHRD LALQRHKHHM GTRYIEVYKA
310 320 330 340 350
TGEDFLKIAG GTSNEVAQFL SKENQVIVRM RGLPFTATAE EVVAFFGQHC
360 370 380 390 400
PITGGKEGIL FVTYPDGRPT GDAFVLFACE EYAQNALRKH KDLLGKRYIE
410 420 430 440 450
LFRSTAAEVQ QVLNRFSSAP LIPLPTAPII PVLPQQFVPP TNVRDCVRLR
460 470 480 490 500
GLPYAATIED ILDFLGEFST DIRTHGVHMV LNHQGRPSGD AFIQMKSTDR
510 520 530 540 550
AFMAAQKYHK KTMKDRYVEV FQCSAEEMNF VLMGGTLNRN GLSPPPCLSP
560 570 580 590 600
PSYTFPAPAA VIPTEAAIYQ PSLLLNPRAL QPSTAYYPAG TQLFMNYTAY
610 620 630 640 650
YPSPPGSPNS LGYFPTAANL SSVPPQPGTV VRMQGLAYNT GVKEILNFFQ
660 670
GYQYATEDGL VHANDQARTV PKEWVCI
Length:677
Mass (Da):75,021
Last modified:May 5, 2009 - v2
Checksum:i671E9585D7A2DA00
GO
Isoform 2 (identifier: B2RYD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-677: YATEDGLVHANDQARTVPKEWVCI → CLKDAW

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):73,039
Checksum:i468895504D9D99B3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei654 – 67724YATED…EWVCI → CLKDAW in isoform 2. 1 PublicationVSP_036958Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040708 Genomic DNA. No translation available.
AABR03042124 Genomic DNA. No translation available.
BC166735 mRNA. Translation: AAI66735.1.
RefSeqiNP_001121036.2. NM_001127564.2. [B2RYD2-2]
UniGeneiRn.161971.

Genome annotation databases

EnsembliENSRNOT00000067129; ENSRNOP00000063046; ENSRNOG00000008184. [B2RYD2-2]
GeneIDi500409.
KEGGirno:500409.
UCSCiRGD:1560481. rat. [B2RYD2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040708 Genomic DNA. No translation available.
AABR03042124 Genomic DNA. No translation available.
BC166735 mRNA. Translation: AAI66735.1.
RefSeqiNP_001121036.2. NM_001127564.2. [B2RYD2-2]
UniGeneiRn.161971.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010846.

PTM databases

PhosphoSiteiB2RYD2.

Proteomic databases

PaxDbiB2RYD2.
PeptideAtlasiB2RYD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067129; ENSRNOP00000063046; ENSRNOG00000008184. [B2RYD2-2]
GeneIDi500409.
KEGGirno:500409.
UCSCiRGD:1560481. rat. [B2RYD2-1]

Organism-specific databases

CTDi54845.
RGDi1560481. Esrp1.

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000112401.
InParanoidiB2RYD2.
KOiK14947.
PhylomeDBiB2RYD2.

Enzyme and pathway databases

ReactomeiR-RNO-6803529. FGFR2 alternative splicing.

Miscellaneous databases

PROiB2RYD2.

Gene expression databases

BgeeiENSRNOG00000008184.
ExpressionAtlasiB2RYD2. baseline and differential.
GenevisibleiB2RYD2. RN.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESRP1_RAT
AccessioniPrimary (citable) accession number: B2RYD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.