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Protein

Epithelial splicing regulatory protein 1

Gene

Esrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-6803529 FGFR2 alternative splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 1
Alternative name(s):
RNA-binding motif protein 35A
RNA-binding protein 35A
Gene namesi
Name:Esrp1
Synonyms:Rbm35a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1560481 Esrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003706311 – 677Epithelial splicing regulatory protein 1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei543PhosphoserineBy similarity1
Modified residuei578Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiB2RYD2
PeptideAtlasiB2RYD2
PRIDEiB2RYD2

PTM databases

PhosphoSitePlusiB2RYD2

Expressioni

Gene expression databases

BgeeiENSRNOG00000008184
ExpressionAtlasiB2RYD2 baseline and differential
GenevisibleiB2RYD2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010846

Structurei

3D structure databases

SMRiB2RYD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 302RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini326 – 406RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini445 – 525RRM 3PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ESRP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365 Eukaryota
ENOG410XPZU LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000112401
InParanoidiB2RYD2
KOiK14947
PhylomeDBiB2RYD2

Family and domain databases

CDDicd12736 RRM1_ESRP1, 1 hit
Gene3Di3.30.420.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034427 ESRP1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000504 RRM_dom
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF53098 SSF53098, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RYD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTASPDYLVV LFGITAGATG AKLGSDEKEL ILLLWKVVDL ANKKVGQLHE
60 70 80 90 100
VLVRPDQLEL TEDCKEETKI DAENLSSAPQ LDQALRQFNQ SVSNELNIGV
110 120 130 140 150
GTSFCLCTDG QLHVRQILHP EASKKNVLLP ECFYSFFDLR KEFKKCCPGS
160 170 180 190 200
PDLDKLDVAA MAESLNFEKN DSMSRYGASQ VEDMGNIILA MISEPYNHRF
210 220 230 240 250
SDPERVNYKF ESGTCSKTEL IDGNTVVRAR GLPWQSSDQD IARFFKGLNI
260 270 280 290 300
AKGGAALCLN AQGRRNGEAL VRFVSEEHRD LALQRHKHHM GTRYIEVYKA
310 320 330 340 350
TGEDFLKIAG GTSNEVAQFL SKENQVIVRM RGLPFTATAE EVVAFFGQHC
360 370 380 390 400
PITGGKEGIL FVTYPDGRPT GDAFVLFACE EYAQNALRKH KDLLGKRYIE
410 420 430 440 450
LFRSTAAEVQ QVLNRFSSAP LIPLPTAPII PVLPQQFVPP TNVRDCVRLR
460 470 480 490 500
GLPYAATIED ILDFLGEFST DIRTHGVHMV LNHQGRPSGD AFIQMKSTDR
510 520 530 540 550
AFMAAQKYHK KTMKDRYVEV FQCSAEEMNF VLMGGTLNRN GLSPPPCLSP
560 570 580 590 600
PSYTFPAPAA VIPTEAAIYQ PSLLLNPRAL QPSTAYYPAG TQLFMNYTAY
610 620 630 640 650
YPSPPGSPNS LGYFPTAANL SSVPPQPGTV VRMQGLAYNT GVKEILNFFQ
660 670
GYQYATEDGL VHANDQARTV PKEWVCI
Length:677
Mass (Da):75,021
Last modified:May 5, 2009 - v2
Checksum:i671E9585D7A2DA00
GO
Isoform 2 (identifier: B2RYD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-677: YATEDGLVHANDQARTVPKEWVCI → CLKDAW

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):73,039
Checksum:i468895504D9D99B3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036958654 – 677YATED…EWVCI → CLKDAW in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040708 Genomic DNA No translation available.
AABR03042124 Genomic DNA No translation available.
BC166735 mRNA Translation: AAI66735.1
RefSeqiNP_001121036.2, NM_001127564.2 [B2RYD2-2]
UniGeneiRn.161971

Genome annotation databases

EnsembliENSRNOT00000067129; ENSRNOP00000063046; ENSRNOG00000008184 [B2RYD2-2]
GeneIDi500409
KEGGirno:500409
UCSCiRGD:1560481 rat [B2RYD2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiESRP1_RAT
AccessioniPrimary (citable) accession number: B2RYD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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