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Protein

Glucosylceramidase

Gene

Gba

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase
Biological processLipid metabolism, Sphingolipid metabolismUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism

Protein family/group databases

CAZyiGH30 Glycoside Hydrolase Family 30

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
Gene namesi
Name:GbaImported
ORF Names:rCG_62590Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1589149 Gba

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501429835920 – 515GlucosylceramidaseSequence analysisAdd BLAST496

Expressioni

Gene expression databases

BgeeiENSRNOG00000049281

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063935

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 445Glyco_hydro_30InterPro annotationAdd BLAST349
Domaini448 – 510Glyco_hydro_30CInterPro annotationAdd BLAST63

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2566 Eukaryota
COG5520 LUCA
GeneTreeiENSGT00390000009464
HOVERGENiHBG002285
KOiK01201
OMAiTYCDSLD
OrthoDBiEOG091G06I4

Family and domain databases

Gene3Di2.60.40.11802 hits
InterProiView protein in InterPro
IPR033452 GH30_C
IPR001139 Glyco_hydro_30
IPR033453 Glyco_hydro_30_TIM-barrel
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11069 PTHR11069, 1 hit
PfamiView protein in Pfam
PF02055 Glyco_hydro_30, 1 hit
PF17189 Glyco_hydro_30C, 1 hit
PRINTSiPR00843 GLHYDRLASE30
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

B2RYC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARFIGLFL FQAISWAYGA QPCIPKSFGY SSVVCVCNAT YCDSLDPLTL
60 70 80 90 100
PALGTFSRYE STRSGRRMEL STGSIQANRT GTGLLLTLQP EEKFQKVKGF
110 120 130 140 150
GGAMTDATAL NILALSPPAQ KLLLKSYFSS EGIEYNIIRV PMASCDFSIR
160 170 180 190 200
IYTYADTPND FQLSNFSLPE EDTKLKIPLI HRALKMSPRP ISLFASPWTS
210 220 230 240 250
PTWLKTNGAV NGKGSLKGHP GDIYHEAWAN YFVKFLDAYA THNIKFWAVT
260 270 280 290 300
AENEPSAGLF TGYPFQCLGF TAEHQRDFIS HDLGPALANS SHDVKLLILD
310 320 330 340 350
DQRLLLPRWA QVVLSDPEAA KYVHGIAVHW YMDFLAPAKA TLGETHRLFP
360 370 380 390 400
NMMLFASEAC VGSKFWEQSV RLGSWDRGMQ YSHSIITNLL YHVTGWTDWN
410 420 430 440 450
LALNPEGGPN WVRNFVDSPI IVDIPKDTFY KQPMFYHLGH FSKFIPEGSQ
460 470 480 490 500
RVGLVASEKT DLETVALIRP DGSAVVVVLN RSSKDVPLTI SDPALGFMET
510
ISPGYSIHTY LWRRQ
Length:515
Mass (Da):57,492
Last modified:July 1, 2008 - v1
Checksum:iF5C7CCCC6C23C79B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072752 Genomic DNA No translation available.
BC166732 mRNA Translation: AAI66732.1
CH473976 Genomic DNA Translation: EDM00662.1
RefSeqiNP_001121111.1, NM_001127639.1
XP_017446595.1, XM_017591106.1
XP_017446596.1, XM_017591107.1
UniGeneiRn.162606

Genome annotation databases

EnsembliENSRNOT00000074727; ENSRNOP00000063935; ENSRNOG00000049281
GeneIDi684536
KEGGirno:684536

Similar proteinsi

Entry informationi

Entry nameiB2RYC9_RAT
AccessioniPrimary (citable) accession number: B2RYC9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported