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B2RY83

- HPSE2_MOUSE

UniProt

B2RY83 - HPSE2_MOUSE

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Protein

Inactive heparanase-2

Gene

Hpse2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity).By similarity

GO - Molecular functioni

  1. hydrolase activity, acting on glycosyl bonds Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198967. HS-GAG degradation.

Protein family/group databases

CAZyiGH79. Glycoside Hydrolase Family 79.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive heparanase-2
Short name:
Hpa2
Gene namesi
Name:Hpse2
Synonyms:Hpa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2685814. Hpse2.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 592554Inactive heparanase-2PRO_0000418888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiB2RY83.

Expressioni

Gene expression databases

BgeeiB2RY83.
GenevestigatoriB2RY83.

Interactioni

Subunit structurei

Interacts with HPSE. Interacts with SDC1 (via glycan chains) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097026.

Structurei

3D structure databases

ProteinModelPortaliB2RY83.
SMRiB2RY83. Positions 205-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 79 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72789.
GeneTreeiENSGT00390000004874.
HOGENOMiHOG000007256.
HOVERGENiHBG081606.
InParanoidiB2RY83.
KOiK07965.
OMAiVNTKSPV.
OrthoDBiEOG7BZVRW.
PhylomeDBiB2RY83.
TreeFamiTF328999.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR005199. Glyco_hydro_79.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR14363. PTHR14363. 1 hit.
PfamiPF03662. Glyco_hydro_79n. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2RY83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVLCAFPEA MASSSSRPPS CLALVALFLA LLLHLSLSFH AGNRRPLPVD
60 70 80 90 100
RATGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR
110 120 130 140 150
LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD
160 170 180 190 200
IVRSDVALDK QKGCKIAQHP DVMLELQREK ASQMHLVLLK EQYSNTYSNL
210 220 230 240 250
ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS
260 270 280 290 300
KKYNISWELG NEPNNYRSIH GRAVNGSQLG KDYIQLKSLL QPIRVYSRAS
310 320 330 340 350
LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK
360 370 380 390 400
TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG
410 420 430 440 450
FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR
460 470 480 490 500
LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF
510 520 530 540 550
IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV
560 570 580 590
DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR
Length:592
Mass (Da):66,685
Last modified:July 1, 2008 - v1
Checksum:iC82F7A502B776E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122312 Genomic DNA. No translation available.
AC124716 Genomic DNA. No translation available.
AC125458 Genomic DNA. No translation available.
AC126795 Genomic DNA. No translation available.
AC140375 Genomic DNA. No translation available.
BC158131 mRNA. Translation: AAI58132.1.
BC158133 mRNA. Translation: AAI58134.1.
BC158136 mRNA. Translation: AAI58137.1.
CCDSiCCDS37993.1.
RefSeqiNP_001074726.1. NM_001081257.2.
UniGeneiMm.442200.

Genome annotation databases

EnsembliENSMUST00000099428; ENSMUSP00000097026; ENSMUSG00000074852.
GeneIDi545291.
KEGGimmu:545291.
UCSCiuc008hoe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122312 Genomic DNA. No translation available.
AC124716 Genomic DNA. No translation available.
AC125458 Genomic DNA. No translation available.
AC126795 Genomic DNA. No translation available.
AC140375 Genomic DNA. No translation available.
BC158131 mRNA. Translation: AAI58132.1 .
BC158133 mRNA. Translation: AAI58134.1 .
BC158136 mRNA. Translation: AAI58137.1 .
CCDSi CCDS37993.1.
RefSeqi NP_001074726.1. NM_001081257.2.
UniGenei Mm.442200.

3D structure databases

ProteinModelPortali B2RY83.
SMRi B2RY83. Positions 205-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000097026.

Protein family/group databases

CAZyi GH79. Glycoside Hydrolase Family 79.

Proteomic databases

PRIDEi B2RY83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099428 ; ENSMUSP00000097026 ; ENSMUSG00000074852 .
GeneIDi 545291.
KEGGi mmu:545291.
UCSCi uc008hoe.2. mouse.

Organism-specific databases

CTDi 60495.
MGIi MGI:2685814. Hpse2.

Phylogenomic databases

eggNOGi NOG72789.
GeneTreei ENSGT00390000004874.
HOGENOMi HOG000007256.
HOVERGENi HBG081606.
InParanoidi B2RY83.
KOi K07965.
OMAi VNTKSPV.
OrthoDBi EOG7BZVRW.
PhylomeDBi B2RY83.
TreeFami TF328999.

Enzyme and pathway databases

Reactomei REACT_198967. HS-GAG degradation.

Miscellaneous databases

NextBioi 412475.
PROi B2RY83.
SOURCEi Search...

Gene expression databases

Bgeei B2RY83.
Genevestigatori B2RY83.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR005199. Glyco_hydro_79.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR14363. PTHR14363. 1 hit.
Pfami PF03662. Glyco_hydro_79n. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHPSE2_MOUSE
AccessioniPrimary (citable) accession number: B2RY83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3