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B2RY83

- HPSE2_MOUSE

UniProt

B2RY83 - HPSE2_MOUSE

Protein

Inactive heparanase-2

Gene

Hpse2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) By similarity.By similarity

    GO - Molecular functioni

    1. hydrolase activity, acting on glycosyl bonds Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_198967. HS-GAG degradation.

    Protein family/group databases

    CAZyiGH79. Glycoside Hydrolase Family 79.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive heparanase-2
    Short name:
    Hpa2
    Gene namesi
    Name:Hpse2
    Synonyms:Hpa2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:2685814. Hpse2.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 592554Inactive heparanase-2PRO_0000418888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi392 – 3921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiB2RY83.

    Expressioni

    Gene expression databases

    BgeeiB2RY83.
    GenevestigatoriB2RY83.

    Interactioni

    Subunit structurei

    Interacts with HPSE. Interacts with SDC1 (via glycan chains) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000097026.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RY83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 79 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72789.
    GeneTreeiENSGT00390000004874.
    HOGENOMiHOG000007256.
    HOVERGENiHBG081606.
    InParanoidiB2RY83.
    KOiK07965.
    OMAiVNTKSPV.
    OrthoDBiEOG7BZVRW.
    PhylomeDBiB2RY83.
    TreeFamiTF328999.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR005199. Glyco_hydro_79.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR14363. PTHR14363. 1 hit.
    PfamiPF03662. Glyco_hydro_79n. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B2RY83-1 [UniParc]FASTAAdd to Basket

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    MRVLCAFPEA MASSSSRPPS CLALVALFLA LLLHLSLSFH AGNRRPLPVD    50
    RATGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR 100
    LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD 150
    IVRSDVALDK QKGCKIAQHP DVMLELQREK ASQMHLVLLK EQYSNTYSNL 200
    ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS 250
    KKYNISWELG NEPNNYRSIH GRAVNGSQLG KDYIQLKSLL QPIRVYSRAS 300
    LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK 350
    TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG 400
    FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR 450
    LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF 500
    IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV 550
    DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR 592
    Length:592
    Mass (Da):66,685
    Last modified:July 1, 2008 - v1
    Checksum:iC82F7A502B776E1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122312 Genomic DNA. No translation available.
    AC124716 Genomic DNA. No translation available.
    AC125458 Genomic DNA. No translation available.
    AC126795 Genomic DNA. No translation available.
    AC140375 Genomic DNA. No translation available.
    BC158131 mRNA. Translation: AAI58132.1.
    BC158133 mRNA. Translation: AAI58134.1.
    BC158136 mRNA. Translation: AAI58137.1.
    CCDSiCCDS37993.1.
    RefSeqiNP_001074726.1. NM_001081257.2.
    UniGeneiMm.442200.

    Genome annotation databases

    EnsembliENSMUST00000099428; ENSMUSP00000097026; ENSMUSG00000074852.
    GeneIDi545291.
    KEGGimmu:545291.
    UCSCiuc008hoe.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122312 Genomic DNA. No translation available.
    AC124716 Genomic DNA. No translation available.
    AC125458 Genomic DNA. No translation available.
    AC126795 Genomic DNA. No translation available.
    AC140375 Genomic DNA. No translation available.
    BC158131 mRNA. Translation: AAI58132.1 .
    BC158133 mRNA. Translation: AAI58134.1 .
    BC158136 mRNA. Translation: AAI58137.1 .
    CCDSi CCDS37993.1.
    RefSeqi NP_001074726.1. NM_001081257.2.
    UniGenei Mm.442200.

    3D structure databases

    ProteinModelPortali B2RY83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000097026.

    Protein family/group databases

    CAZyi GH79. Glycoside Hydrolase Family 79.

    Proteomic databases

    PRIDEi B2RY83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099428 ; ENSMUSP00000097026 ; ENSMUSG00000074852 .
    GeneIDi 545291.
    KEGGi mmu:545291.
    UCSCi uc008hoe.2. mouse.

    Organism-specific databases

    CTDi 60495.
    MGIi MGI:2685814. Hpse2.

    Phylogenomic databases

    eggNOGi NOG72789.
    GeneTreei ENSGT00390000004874.
    HOGENOMi HOG000007256.
    HOVERGENi HBG081606.
    InParanoidi B2RY83.
    KOi K07965.
    OMAi VNTKSPV.
    OrthoDBi EOG7BZVRW.
    PhylomeDBi B2RY83.
    TreeFami TF328999.

    Enzyme and pathway databases

    Reactomei REACT_198967. HS-GAG degradation.

    Miscellaneous databases

    NextBioi 412475.
    PROi B2RY83.
    SOURCEi Search...

    Gene expression databases

    Bgeei B2RY83.
    Genevestigatori B2RY83.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR005199. Glyco_hydro_79.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR14363. PTHR14363. 1 hit.
    Pfami PF03662. Glyco_hydro_79n. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHPSE2_MOUSE
    AccessioniPrimary (citable) accession number: B2RY83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3