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B2RY83 (HPSE2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive heparanase-2

Short name=Hpa2
Gene names
Name:Hpse2
Synonyms:Hpa2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) By similarity.

Subunit structure

Interacts with HPSE. Interacts with SDC1 (via glycan chains) By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 79 family.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmembrane

Inferred from electronic annotation. Source: InterPro

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhydrolase activity, acting on glycosyl bonds

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 592554Inactive heparanase-2
PRO_0000418888

Amino acid modifications

Glycosylation2541N-linked (GlcNAc...) Potential
Glycosylation3921N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B2RY83 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: C82F7A502B776E1F

FASTA59266,685
        10         20         30         40         50         60 
MRVLCAFPEA MASSSSRPPS CLALVALFLA LLLHLSLSFH AGNRRPLPVD RATGLKEKTL 

        70         80         90        100        110        120 
ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR LVTLARGLSP AFLRFGGKRT 

       130        140        150        160        170        180 
DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD IVRSDVALDK QKGCKIAQHP DVMLELQREK 

       190        200        210        220        230        240 
ASQMHLVLLK EQYSNTYSNL ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS 

       250        260        270        280        290        300 
ALSLLKYSAS KKYNISWELG NEPNNYRSIH GRAVNGSQLG KDYIQLKSLL QPIRVYSRAS 

       310        320        330        340        350        360 
LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK TRLLDTLSDQ 

       370        380        390        400        410        420 
IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG FLWLNTLGML ANQGIDVVIR 

       430        440        450        460        470        480 
HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI 

       490        500        510        520        530        540 
YAHCTNHHNH NYVRGSITLF IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV 

       550        560        570        580        590 
QLNGQPLVMV DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC122312 Genomic DNA. No translation available.
AC124716 Genomic DNA. No translation available.
AC125458 Genomic DNA. No translation available.
AC126795 Genomic DNA. No translation available.
AC140375 Genomic DNA. No translation available.
BC158131 mRNA. Translation: AAI58132.1.
BC158133 mRNA. Translation: AAI58134.1.
BC158136 mRNA. Translation: AAI58137.1.
CCDSCCDS37993.1.
RefSeqNP_001074726.1. NM_001081257.2.
UniGeneMm.442200.

3D structure databases

ProteinModelPortalB2RY83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000097026.

Protein family/group databases

CAZyGH79. Glycoside Hydrolase Family 79.

Proteomic databases

PRIDEB2RY83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099428; ENSMUSP00000097026; ENSMUSG00000074852.
GeneID545291.
KEGGmmu:545291.
UCSCuc008hoe.2. mouse.

Organism-specific databases

CTD60495.
MGIMGI:2685814. Hpse2.

Phylogenomic databases

eggNOGNOG72789.
GeneTreeENSGT00390000004874.
HOGENOMHOG000007256.
HOVERGENHBG081606.
InParanoidB2RY83.
KOK07965.
OMAVNTKSPV.
OrthoDBEOG7BZVRW.
PhylomeDBB2RY83.
TreeFamTF328999.

Gene expression databases

BgeeB2RY83.
GenevestigatorB2RY83.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR005199. Glyco_hydro_79.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR14363. PTHR14363. 1 hit.
PfamPF03662. Glyco_hydro_79n. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 2 hits.
ProtoNetSearch...

Other

NextBio412475.
PROB2RY83.
SOURCESearch...

Entry information

Entry nameHPSE2_MOUSE
AccessionPrimary (citable) accession number: B2RY83
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries