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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

Gene

Ankrd44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Short name:
PP6-ARS-B
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Alternative name(s):
Ankyrin repeat domain-containing protein 44
Gene namesi
Name:Ankrd44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3045243. Ankrd44.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 993993Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit BPRO_0000355975Add
BLAST

Proteomic databases

EPDiB2RXR6.
MaxQBiB2RXR6.
PaxDbiB2RXR6.
PeptideAtlasiB2RXR6.
PRIDEiB2RXR6.

PTM databases

iPTMnetiB2RXR6.
PhosphoSiteiB2RXR6.

Expressioni

Gene expression databases

BgeeiB2RXR6.
ExpressionAtlasiB2RXR6. baseline and differential.
GenevisibleiB2RXR6. MM.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1 (By similarity).By similarity

Protein-protein interaction databases

IntActiB2RXR6. 5 interactions.
STRINGi10090.ENSMUSP00000137616.

Structurei

3D structure databases

ProteinModelPortaliB2RXR6.
SMRiB2RXR6. Positions 11-981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 3630ANK 1Add
BLAST
Repeati40 – 6930ANK 2Add
BLAST
Repeati73 – 10230ANK 3Add
BLAST
Repeati106 – 13530ANK 4Add
BLAST
Repeati139 – 16830ANK 5Add
BLAST
Repeati172 – 20130ANK 6Add
BLAST
Repeati205 – 23430ANK 7Add
BLAST
Repeati238 – 26730ANK 8Add
BLAST
Repeati271 – 30131ANK 9Add
BLAST
Repeati305 – 33430ANK 10Add
BLAST
Repeati338 – 36730ANK 11Add
BLAST
Repeati371 – 40030ANK 12Add
BLAST
Repeati404 – 43330ANK 13Add
BLAST
Repeati437 – 46630ANK 14Add
BLAST
Repeati470 – 49829ANK 15Add
BLAST
Repeati531 – 56131ANK 16Add
BLAST
Repeati566 – 59530ANK 17Add
BLAST
Repeati599 – 62830ANK 18Add
BLAST
Repeati633 – 66230ANK 19Add
BLAST
Repeati669 – 69830ANK 20Add
BLAST
Repeati702 – 73130ANK 21Add
BLAST
Repeati735 – 76430ANK 22Add
BLAST
Repeati771 – 80030ANK 23Add
BLAST
Repeati803 – 83230ANK 24Add
BLAST
Repeati838 – 86730ANK 25Add
BLAST
Repeati871 – 90131ANK 26Add
BLAST
Repeati905 – 93430ANK 27Add
BLAST
Repeati941 – 97030ANK 28Add
BLAST

Sequence similaritiesi

Contains 28 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiB2RXR6.
KOiK15503.
OrthoDBiEOG7QG436.
PhylomeDBiB2RXR6.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 10 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RXR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLKLCEQP PLVQAIFSGD PEEIRMLIHK TEDVNALDSE KRTPLHVAAF
60 70 80 90 100
LGDAEIIELL ILSGARVNAK DNMWLTPLHR AVASRSEEAV QVLIKHSADV
110 120 130 140 150
NARDKNWQTP LHVAAANKAV KCAEVIIPLL SSVNVSDRGG RTALHHAALN
160 170 180 190 200
GHMEMVNLLL AKGANINAFD KKDRRALHWA AYMGHLDVVA LLINHGAEVT
210 220 230 240 250
CKDKKGYTPL HAAASNGQIS VVKHLLNLGV EIDEINVYGN TALHIACYNG
260 270 280 290 300
QDAVVNELID YGANVNQPNN SGFTPLHFAA ASTHGALCLE LLVNNGADVN
310 320 330 340 350
IQSKDGKSPL HMTAVHGRFT RSQTLIQNGG EIDCVDKDGN TPLHVAARHG
360 370 380 390 400
HELLINTLIT SGADTAKCGI HSMFPLHLAA LNAHSDCCRK LLSSGFEIDT
410 420 430 440 450
PDTFGRTCLH AAAAGGNVEC IKLLQSSGAD FHKKDKCGRT PLHYAAANCH
460 470 480 490 500
FHCIKALVTT GANVNETDDW GRTALHYAAA SDMDRNKMIL GNAHDNSEEL
510 520 530 540 550
ERAREVKEKD AALCLEFLLQ NDANPSIRDK EGYNSIHYAA AYGHRQCLEL
560 570 580 590 600
LLERTNTGFE ESDGGALKSP LHLAAYNGHH QALEVLLQSL VDLDIRDEKG
610 620 630 640 650
RTALYLAAFK GHTECVEALV NQGASIFVKD NVTKRTPLHA SVINGHTLCL
660 670 680 690 700
RLLLETADNP EVVDVKDAKG QTPLMLAVAY GHIDAVSLLL EKEANVDAVD
710 720 730 740 750
IVGCTALHRG IMTGHEECVQ MLLEQEASIL CKDSRGRTPL HYAAARGHAT
760 770 780 790 800
WLNELLQIAL SEEDCCLKDN QGYTPLHWAC YNGNENCIEV LLEQKCFRKF
810 820 830 840 850
IGNPFTPLHC AIINGHESCA SLLLGAIDPS IVSCRDDKGR TTLHAAAFGD
860 870 880 890 900
HAECLQLLLR HDAQVNAVDN SGKTALMMAA ENGQAGAVDI LVNSAQADLT
910 920 930 940 950
VKDKDLNTPL HLAISKGHEK CALLILDKIQ DESLINAKNS ALQTPLHIAA
960 970 980 990
RNGLKVVVEE LLAKGACVLA VDENASRSNG PRSPPGTAVR KEE
Length:993
Mass (Da):107,385
Last modified:July 1, 2008 - v1
Checksum:i56BDAE434659C072
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631S → L in AAI57919 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157918 mRNA. Translation: AAI57919.1.
BC157951 mRNA. Translation: AAI57952.1.
BC172102 mRNA. Translation: AAI72102.1.
CCDSiCCDS35566.2.
RefSeqiNP_001074902.2. NM_001081433.3.
UniGeneiMm.397910.

Genome annotation databases

EnsembliENSMUST00000179030; ENSMUSP00000137616; ENSMUSG00000052331.
GeneIDi329154.
KEGGimmu:329154.
UCSCiuc011wkz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157918 mRNA. Translation: AAI57919.1.
BC157951 mRNA. Translation: AAI57952.1.
BC172102 mRNA. Translation: AAI72102.1.
CCDSiCCDS35566.2.
RefSeqiNP_001074902.2. NM_001081433.3.
UniGeneiMm.397910.

3D structure databases

ProteinModelPortaliB2RXR6.
SMRiB2RXR6. Positions 11-981.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB2RXR6. 5 interactions.
STRINGi10090.ENSMUSP00000137616.

PTM databases

iPTMnetiB2RXR6.
PhosphoSiteiB2RXR6.

Proteomic databases

EPDiB2RXR6.
MaxQBiB2RXR6.
PaxDbiB2RXR6.
PeptideAtlasiB2RXR6.
PRIDEiB2RXR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179030; ENSMUSP00000137616; ENSMUSG00000052331.
GeneIDi329154.
KEGGimmu:329154.
UCSCiuc011wkz.1. mouse.

Organism-specific databases

CTDi91526.
MGIiMGI:3045243. Ankrd44.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiB2RXR6.
KOiK15503.
OrthoDBiEOG7QG436.
PhylomeDBiB2RXR6.

Miscellaneous databases

ChiTaRSiAnkrd44. mouse.
PROiB2RXR6.
SOURCEiSearch...

Gene expression databases

BgeeiB2RXR6.
ExpressionAtlasiB2RXR6. baseline and differential.
GenevisibleiB2RXR6. MM.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 10 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiANR44_MOUSE
AccessioniPrimary (citable) accession number: B2RXR6
Secondary accession number(s): B2RXN6, B7ZWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.