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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

Gene

Ankrd44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Short name:
PP6-ARS-B
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Alternative name(s):
Ankyrin repeat domain-containing protein 44
Gene namesi
Name:Ankrd44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3045243. Ankrd44.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003559751 – 993Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit BAdd BLAST993

Proteomic databases

EPDiB2RXR6.
MaxQBiB2RXR6.
PaxDbiB2RXR6.
PeptideAtlasiB2RXR6.
PRIDEiB2RXR6.

PTM databases

iPTMnetiB2RXR6.
PhosphoSitePlusiB2RXR6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052331.
ExpressionAtlasiB2RXR6. baseline and differential.
GenevisibleiB2RXR6. MM.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1 (By similarity).By similarity

Protein-protein interaction databases

IntActiB2RXR6. 5 interactors.
STRINGi10090.ENSMUSP00000137616.

Structurei

3D structure databases

ProteinModelPortaliB2RXR6.
SMRiB2RXR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 36ANK 1Add BLAST30
Repeati40 – 69ANK 2Add BLAST30
Repeati73 – 102ANK 3Add BLAST30
Repeati106 – 135ANK 4Add BLAST30
Repeati139 – 168ANK 5Add BLAST30
Repeati172 – 201ANK 6Add BLAST30
Repeati205 – 234ANK 7Add BLAST30
Repeati238 – 267ANK 8Add BLAST30
Repeati271 – 301ANK 9Add BLAST31
Repeati305 – 334ANK 10Add BLAST30
Repeati338 – 367ANK 11Add BLAST30
Repeati371 – 400ANK 12Add BLAST30
Repeati404 – 433ANK 13Add BLAST30
Repeati437 – 466ANK 14Add BLAST30
Repeati470 – 498ANK 15Add BLAST29
Repeati531 – 561ANK 16Add BLAST31
Repeati566 – 595ANK 17Add BLAST30
Repeati599 – 628ANK 18Add BLAST30
Repeati633 – 662ANK 19Add BLAST30
Repeati669 – 698ANK 20Add BLAST30
Repeati702 – 731ANK 21Add BLAST30
Repeati735 – 764ANK 22Add BLAST30
Repeati771 – 800ANK 23Add BLAST30
Repeati803 – 832ANK 24Add BLAST30
Repeati838 – 867ANK 25Add BLAST30
Repeati871 – 901ANK 26Add BLAST31
Repeati905 – 934ANK 27Add BLAST30
Repeati941 – 970ANK 28Add BLAST30

Sequence similaritiesi

Contains 28 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiB2RXR6.
KOiK15503.
PhylomeDBiB2RXR6.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 10 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RXR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLKLCEQP PLVQAIFSGD PEEIRMLIHK TEDVNALDSE KRTPLHVAAF
60 70 80 90 100
LGDAEIIELL ILSGARVNAK DNMWLTPLHR AVASRSEEAV QVLIKHSADV
110 120 130 140 150
NARDKNWQTP LHVAAANKAV KCAEVIIPLL SSVNVSDRGG RTALHHAALN
160 170 180 190 200
GHMEMVNLLL AKGANINAFD KKDRRALHWA AYMGHLDVVA LLINHGAEVT
210 220 230 240 250
CKDKKGYTPL HAAASNGQIS VVKHLLNLGV EIDEINVYGN TALHIACYNG
260 270 280 290 300
QDAVVNELID YGANVNQPNN SGFTPLHFAA ASTHGALCLE LLVNNGADVN
310 320 330 340 350
IQSKDGKSPL HMTAVHGRFT RSQTLIQNGG EIDCVDKDGN TPLHVAARHG
360 370 380 390 400
HELLINTLIT SGADTAKCGI HSMFPLHLAA LNAHSDCCRK LLSSGFEIDT
410 420 430 440 450
PDTFGRTCLH AAAAGGNVEC IKLLQSSGAD FHKKDKCGRT PLHYAAANCH
460 470 480 490 500
FHCIKALVTT GANVNETDDW GRTALHYAAA SDMDRNKMIL GNAHDNSEEL
510 520 530 540 550
ERAREVKEKD AALCLEFLLQ NDANPSIRDK EGYNSIHYAA AYGHRQCLEL
560 570 580 590 600
LLERTNTGFE ESDGGALKSP LHLAAYNGHH QALEVLLQSL VDLDIRDEKG
610 620 630 640 650
RTALYLAAFK GHTECVEALV NQGASIFVKD NVTKRTPLHA SVINGHTLCL
660 670 680 690 700
RLLLETADNP EVVDVKDAKG QTPLMLAVAY GHIDAVSLLL EKEANVDAVD
710 720 730 740 750
IVGCTALHRG IMTGHEECVQ MLLEQEASIL CKDSRGRTPL HYAAARGHAT
760 770 780 790 800
WLNELLQIAL SEEDCCLKDN QGYTPLHWAC YNGNENCIEV LLEQKCFRKF
810 820 830 840 850
IGNPFTPLHC AIINGHESCA SLLLGAIDPS IVSCRDDKGR TTLHAAAFGD
860 870 880 890 900
HAECLQLLLR HDAQVNAVDN SGKTALMMAA ENGQAGAVDI LVNSAQADLT
910 920 930 940 950
VKDKDLNTPL HLAISKGHEK CALLILDKIQ DESLINAKNS ALQTPLHIAA
960 970 980 990
RNGLKVVVEE LLAKGACVLA VDENASRSNG PRSPPGTAVR KEE
Length:993
Mass (Da):107,385
Last modified:July 1, 2008 - v1
Checksum:i56BDAE434659C072
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63S → L in AAI57919 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157918 mRNA. Translation: AAI57919.1.
BC157951 mRNA. Translation: AAI57952.1.
BC172102 mRNA. Translation: AAI72102.1.
CCDSiCCDS35566.2.
RefSeqiNP_001074902.2. NM_001081433.3.
UniGeneiMm.397910.

Genome annotation databases

EnsembliENSMUST00000179030; ENSMUSP00000137616; ENSMUSG00000052331.
GeneIDi329154.
KEGGimmu:329154.
UCSCiuc011wkz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157918 mRNA. Translation: AAI57919.1.
BC157951 mRNA. Translation: AAI57952.1.
BC172102 mRNA. Translation: AAI72102.1.
CCDSiCCDS35566.2.
RefSeqiNP_001074902.2. NM_001081433.3.
UniGeneiMm.397910.

3D structure databases

ProteinModelPortaliB2RXR6.
SMRiB2RXR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB2RXR6. 5 interactors.
STRINGi10090.ENSMUSP00000137616.

PTM databases

iPTMnetiB2RXR6.
PhosphoSitePlusiB2RXR6.

Proteomic databases

EPDiB2RXR6.
MaxQBiB2RXR6.
PaxDbiB2RXR6.
PeptideAtlasiB2RXR6.
PRIDEiB2RXR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179030; ENSMUSP00000137616; ENSMUSG00000052331.
GeneIDi329154.
KEGGimmu:329154.
UCSCiuc011wkz.1. mouse.

Organism-specific databases

CTDi91526.
MGIiMGI:3045243. Ankrd44.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiB2RXR6.
KOiK15503.
PhylomeDBiB2RXR6.

Miscellaneous databases

ChiTaRSiAnkrd44. mouse.
PROiB2RXR6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052331.
ExpressionAtlasiB2RXR6. baseline and differential.
GenevisibleiB2RXR6. MM.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 10 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR44_MOUSE
AccessioniPrimary (citable) accession number: B2RXR6
Secondary accession number(s): B2RXN6, B7ZWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.