ID   B2RXQ2_MOUSE            Unreviewed;      1266 AA.
AC   B2RXQ2;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=Ppfia1 protein {ECO:0000313|EMBL:AAI57937.1};
DE   SubName: Full=Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 1 {ECO:0000313|Ensembl:ENSMUSP00000138312.2};
GN   Name=Ppfia1 {ECO:0000313|EMBL:AAI57937.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000138312.2,
GN   ECO:0000313|MGI:MGI:1924750};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI57937.1};
RN   [1] {ECO:0000313|EMBL:AAI57937.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI57937.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [3] {ECO:0007829|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000138312.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138312.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000138312.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138312.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC       {ECO:0000256|ARBA:ARBA00007026}.
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DR   EMBL; BC157936; AAI57937.1; -; mRNA.
DR   EMBL; BC172096; AAI72096.1; -; mRNA.
DR   RefSeq; NP_001182015.1; NM_001195086.1.
DR   IntAct; B2RXQ2; 2.
DR   STRING; 10090.ENSMUSP00000138312; -.
DR   CPTAC; non-CPTAC-3436; -.
DR   ProteomicsDB; 330648; -.
DR   Antibodypedia; 30679; 234 antibodies from 31 providers.
DR   Ensembl; ENSMUST00000182226.8; ENSMUSP00000138312.2; ENSMUSG00000037519.18.
DR   GeneID; 233977; -.
DR   UCSC; uc012fxz.1; mouse.
DR   AGR; MGI:1924750; -.
DR   CTD; 8500; -.
DR   MGI; MGI:1924750; Ppfia1.
DR   VEuPathDB; HostDB:ENSMUSG00000037519; -.
DR   GeneTree; ENSGT01050000244900; -.
DR   OrthoDB; 2906732at2759; -.
DR   Reactome; R-MMU-181429; Serotonin Neurotransmitter Release Cycle.
DR   Reactome; R-MMU-181430; Norepinephrine Neurotransmitter Release Cycle.
DR   Reactome; R-MMU-210500; Glutamate Neurotransmitter Release Cycle.
DR   Reactome; R-MMU-212676; Dopamine Neurotransmitter Release Cycle.
DR   Reactome; R-MMU-264642; Acetylcholine Neurotransmitter Release Cycle.
DR   Reactome; R-MMU-388844; Receptor-type tyrosine-protein phosphatases.
DR   BioGRID-ORCS; 233977; 4 hits in 79 CRISPR screens.
DR   ChiTaRS; Ppfia1; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000037519; Expressed in animal zygote and 230 other cell types or tissues.
DR   GO; GO:0030424; C:axon; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0030425; C:dendrite; ISO:MGI.
DR   GO; GO:0005925; C:focal adhesion; ISO:MGI.
DR   GO; GO:0048786; C:presynaptic active zone; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; ISO:MGI.
DR   GO; GO:0097444; C:spine apparatus; ISO:MGI.
DR   GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; ISO:MGI.
DR   GO; GO:0051497; P:negative regulation of stress fiber assembly; IDA:MGI.
DR   GO; GO:0099072; P:regulation of postsynaptic membrane neurotransmitter receptor levels; ISO:MGI.
DR   GO; GO:0050808; P:synapse organization; IBA:GO_Central.
DR   CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR   CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR   CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR   InterPro; IPR029515; Liprin.
DR   InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR   InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR   InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR   PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   SMART; SM00454; SAM; 3.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR   PROSITE; PS50105; SAM_DOMAIN; 3.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|EPD:B2RXQ2,
KW   ECO:0007829|MaxQB:B2RXQ2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          912..978
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          1034..1091
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          1115..1184
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          675..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1231..1252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          97..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          265..387
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          493..541
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        705..723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        745..771
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..806
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        807..827
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        864..879
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1266 AA;  142676 MW;  545C3EFBF1067EBC CRC64;
     MMCEVMPTIS EAEGPPGGGG SHGSGSPSQP DADSHFEQLM VSMLEERDRL LDTLRETQET
     LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC REQLLEREEE IAELKAERNN
     TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PAGVSSEVEV LKALKSLFEH HKALDEKVRE
     RLRVALERCS LLEEELGATH KELMILKEQN NQKKTLTDGL LDGNHEQESA PSTNGKRSSD
     GSLSHEDLAK VLELQEVIDR QAREQSQMKE RLASLSSHAA ELEEDLDTAR KDLIKSEEMN
     TKLQREVREA MAQKEDMEER ITTLEKRYLA AQREATSVHD LNDKLENEIA NKDSMHRQTE
     DKNRQLQERL ELAEQKLQQT LRKAETLPEV EAELAQRVAA LSKSGPLSSG SSAAKEAKLL
     ELTSKLRKAE ERHGNIEERL RQMEAQLEEK NQELQRARQR EKMNEEHNKR LSDTVDKLLS
     ESNERLQLHL KERMAALEDK NSLLREVENA KKQLEETQHD KDQLVVTIEA LKAELEQMRL
     RGPSLHHGRP HLGSVPDFRF SVADGHVDAY STSAVLRRPQ KGRLAALRDE PSKVQTLNEQ
     DWERAQQASV LANVAQAFES DVDVSDGEDD RDTLLSSVDL LSPSGQADAQ TLAMMLQEQL
     DAINKEIRLI QEEKENTEQR AEEIESRVGS GSLDNLGRFR SMSSIPPYPA SSLAGSSPPG
     SGRSTPRRVP HSPAREVDRL GVMTLPSDLR KHRRQLPASR EEVRDDKTTI KCETSPPSSP
     RPLRLDRMHK GAPHTVSHED IRDLRNSTGS QDGPVSNPSS SNSSQDSLHK APKKKGIKSS
     IGRLFGKKEK GRPGPLGKES PGQVGVSETE NSSQDALGLS KLGGQAEKNR KLQKKHELLE
     EARRQGLPFA QWDGPTVVVW LELWVGMPAW YVAACRANVK SGAIMSALSD TEIQREIGIS
     NPLHRLKLRL AIQEIMSLTS PSAPPTSRTT TGNVWLTHEE METLTATPQT EDEEGSWAQT
     LAYGDMNHEW IGNEWLPSLG LPQYRSYFME CLVDARMLDH LTKKDLRGQL KMVDSFHRNS
     FQCGIMCLRR LNYDRKELER KREESQNETR DVLVWSNDRV IRWILSIGLK EYANNLIESG
     VHGALLALDE TFDFSALALL LQIPTQNTQA RAVLEREFNN LLITGTDRRF DEDDDKSFRR
     APSWRKKFRP KDIRGLASGS AETLPANFRV TSSMSSPSMQ PKKVQMDGSV SGAQRLDSAT
     VRTYSC
//