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Protein

Alpha N-terminal protein methyltransferase 1B

Gene

Mettl11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241S-adenosyl-L-methionine; via carbonyl oxygenBy similarity
Binding sitei129 – 1291S-adenosyl-L-methionineBy similarity
Binding sitei190 – 1901S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha N-terminal protein methyltransferase 1B (EC:2.1.1.299)
Alternative name(s):
Methyltransferase-like protein 11B
X-Pro-Lys N-terminal protein methyltransferase 1B
Short name:
NTM1B
Gene namesi
Name:Mettl11b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685053. Mettl11b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Alpha N-terminal protein methyltransferase 1BPRO_0000399779Add
BLAST

Proteomic databases

PaxDbiB2RXM4.
PRIDEiB2RXM4.

Expressioni

Gene expression databases

BgeeiB2RXM4.
ExpressionAtlasiB2RXM4. baseline and differential.
GenevisibleiB2RXM4. MM.

Structurei

3D structure databases

ProteinModelPortaliB2RXM4.
SMRiB2RXM4. Positions 58-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 1752S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3178. Eukaryota.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00390000008371.
HOGENOMiHOG000161910.
HOVERGENiHBG054992.
InParanoidiB2RXM4.
KOiK19579.
OMAiFALHSDR.
OrthoDBiEOG7ZPNM6.
PhylomeDBiB2RXM4.
TreeFamiTF314174.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiPF05891. Methyltransf_PK. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RXM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHLGAHFAF RSRWQKTDDE LCRHSMSFIL HKAIRNDFFQ SYLYLLEKIP
60 70 80 90 100
LVKLYALTSQ VIDGEMQFYA RAKLFYQEVP ATEEGMMGNF IELSNPDIQA
110 120 130 140 150
SREFLRKFVG GPGRAGTGCA LDCGSGIGRV SKHVLLPVFS SVELVDMMES
160 170 180 190 200
FLLEAQSYLQ VNEDKVESYH CYSLQEFTPH LGRYDVIWIQ WVSGYLTDKD
210 220 230 240 250
LLAFLSRCRD GLKENGVIIL KDNVAREGCI FDLSDSSVTR DMDILRSLIR
260 270 280
KSGLVVLGQE KQEGFPEQCV PVWMFALHSD RHS
Length:283
Mass (Da):32,313
Last modified:July 1, 2008 - v1
Checksum:iA1D369AADB3AC17B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466520 Genomic DNA. Translation: EDL39274.1.
BC157906 mRNA. Translation: AAI57907.1.
BC158115 mRNA. Translation: AAI58116.1.
BC172048 mRNA. Translation: AAI72048.1.
CCDSiCCDS48420.1.
RefSeqiNP_001137428.1. NM_001143956.1.
UniGeneiMm.484621.

Genome annotation databases

EnsembliENSMUST00000159679; ENSMUSP00000124211; ENSMUSG00000040113.
GeneIDi240879.
KEGGimmu:240879.
UCSCiuc011wus.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466520 Genomic DNA. Translation: EDL39274.1.
BC157906 mRNA. Translation: AAI57907.1.
BC158115 mRNA. Translation: AAI58116.1.
BC172048 mRNA. Translation: AAI72048.1.
CCDSiCCDS48420.1.
RefSeqiNP_001137428.1. NM_001143956.1.
UniGeneiMm.484621.

3D structure databases

ProteinModelPortaliB2RXM4.
SMRiB2RXM4. Positions 58-277.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiB2RXM4.
PRIDEiB2RXM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159679; ENSMUSP00000124211; ENSMUSG00000040113.
GeneIDi240879.
KEGGimmu:240879.
UCSCiuc011wus.1. mouse.

Organism-specific databases

CTDi149281.
MGIiMGI:2685053. Mettl11b.

Phylogenomic databases

eggNOGiKOG3178. Eukaryota.
ENOG410XS7T. LUCA.
GeneTreeiENSGT00390000008371.
HOGENOMiHOG000161910.
HOVERGENiHBG054992.
InParanoidiB2RXM4.
KOiK19579.
OMAiFALHSDR.
OrthoDBiEOG7ZPNM6.
PhylomeDBiB2RXM4.
TreeFamiTF314174.

Miscellaneous databases

PROiB2RXM4.
SOURCEiSearch...

Gene expression databases

BgeeiB2RXM4.
ExpressionAtlasiB2RXM4. baseline and differential.
GenevisibleiB2RXM4. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiPF05891. Methyltransf_PK. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNTM1B_MOUSE
AccessioniPrimary (citable) accession number: B2RXM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.