B2RXF5 (ZBT42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 42

Gene names

Name:

ZBTB42

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus. Nucleus › nucleoplasm By similarity. Note: In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions By similarity.
Tissue specificity	Expressed in skeletal muscle. Ref.3
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. ZNF238 subfamily. Contains 1 BTB (POZ) domain. Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Zinc finger and BTB domain-containing protein 42		PRO_0000343711
Regions
	Domain	24 – 92	69	BTB
	Zinc finger	294 – 316	23	C2H2-type 1
	Zinc finger	334 – 356	23	C2H2-type 2
	Zinc finger	362 – 384	23	C2H2-type 3
	Zinc finger	390 – 413	24	C2H2-type 4
	Compositional bias	127 – 252	126	Pro-rich
Experimental info
	Sequence conflict	232	1	E → K in AAI57834. Ref.2
	Sequence conflict	232	1	E → K in AAI71822. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	B2RXF5 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: CA057072A5C67DE8	FASTA	422	46,491
	10 20 30 40 50 60 MEFPEHGGRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDRPAGS 70 80 90 100 110 120 RDTVRLNGDI VTAPAFGRLL DFMYEGRLDL RSLPVEDVLA AASYLHMYDI VKVCKGRLQE 130 140 150 160 170 180 KDRSLDPGNP APGAEPAQPP CPWPVWTADL CPAARKAKLP PFGVKAALPP RASGPPPCQV 190 200 210 220 230 240 PEESDQALDL SLKSGPRQER VHPPCVLQTP LCSQRQPGAQ PLVKDERDSL SEQEESSSSR 250 260 270 280 290 300 SPHSPPKPPP VPAAKGLVVG LQPLPLSGEG SRELELGAGR LASEDELGPG GPLCICPLCS 310 320 330 340 350 360 KLFPSSHVLQ LHLSAHFRER DSTRARLSPD GVAPTCPLCG KTFSCTYTLK RHERTHSGEK 370 380 390 400 410 420 PYTCVQCGKS FQYSHNLSRH TVVHTREKPH ACRWCERRFT QSGDLYRHVR KFHCGLVKSL LV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Brain cortex.
[3]	"Characterization of the ZBTB42 gene in humans and mice." Devaney S.A., Mate S.E., Devaney J.M., Hoffman E.P. Hum. Genet. 129:433-441(2011) [PubMed: 21193930] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590327 Genomic DNA. No translation available. BC157833 mRNA. Translation: AAI57834.1. BC171822 mRNA. Translation: AAI71822.1.
IPI	IPI00887704.
RefSeq	NP_001131073.1. NM_001137601.1.
UniGene	Hs.170853.
3D structure databases
ProteinModelPortal	B2RXF5.
SMR	B2RXF5. Positions 1-119, 291-419.
ModBase	Search...
Proteomic databases
PRIDE	B2RXF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342537; ENSP00000409107; ENSG00000179627.
GeneID	100128927.
KEGG	hsa:100128927.
UCSC	uc001ypo.2. human.
Organism-specific databases
CTD	100128927.
GeneCards	GC14P105266.
HGNC	HGNC:32550. ZBTB42.
MIM	613915. gene.
neXtProt	NX_B2RXF5.
PharmGKB	PA144596242.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084014.
HOGENOM	HBG717232.
HOVERGEN	HBG059113.
OMA	DHSRQLL.
OrthoDB	EOG4NZTTM.
PhylomeDB	B2RXF5.
Gene expression databases
Bgee	B2RXF5.
CleanEx	HS_ZBTB42.
Genevestigator	B2RXF5.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

ZBT42_HUMAN

Accession

Primary (citable) accession number: B2RXF5
Secondary accession number(s): B7ZW21

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	November 24, 2009
Last modified:	January 25, 2012
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.