ID   T229A_HUMAN             Reviewed;         380 AA.
AC   B2RXF0; A4D0X6;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   24-JAN-2024, entry version 89.
DE   RecName: Full=Transmembrane protein 229A;
GN   Name=TMEM229A;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM229 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL24328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC004690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236947; EAL24328.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC157828; AAI57829.1; -; mRNA.
DR   EMBL; BC171809; AAI71809.1; -; mRNA.
DR   CCDS; CCDS47694.1; -.
DR   RefSeq; NP_001129474.1; NM_001136002.1.
DR   AlphaFoldDB; B2RXF0; -.
DR   STRING; 9606.ENSP00000395244; -.
DR   iPTMnet; B2RXF0; -.
DR   PhosphoSitePlus; B2RXF0; -.
DR   BioMuta; TMEM229A; -.
DR   MassIVE; B2RXF0; -.
DR   PaxDb; 9606-ENSP00000395244; -.
DR   PeptideAtlas; B2RXF0; -.
DR   ProteomicsDB; 3460; -.
DR   Antibodypedia; 55409; 52 antibodies from 12 providers.
DR   DNASU; 730130; -.
DR   Ensembl; ENST00000455783.3; ENSP00000395244.1; ENSG00000234224.3.
DR   GeneID; 730130; -.
DR   KEGG; hsa:730130; -.
DR   MANE-Select; ENST00000455783.3; ENSP00000395244.1; NM_001136002.2; NP_001129474.1.
DR   UCSC; uc011kob.3; human.
DR   AGR; HGNC:37279; -.
DR   CTD; 730130; -.
DR   GeneCards; TMEM229A; -.
DR   HGNC; HGNC:37279; TMEM229A.
DR   HPA; ENSG00000234224; Tissue enhanced (brain, intestine, testis).
DR   neXtProt; NX_B2RXF0; -.
DR   OpenTargets; ENSG00000234224; -.
DR   PharmGKB; PA165618420; -.
DR   VEuPathDB; HostDB:ENSG00000234224; -.
DR   eggNOG; ENOG502QUNK; Eukaryota.
DR   GeneTree; ENSGT00390000010899; -.
DR   HOGENOM; CLU_048581_0_0_1; -.
DR   InParanoid; B2RXF0; -.
DR   OMA; FHLVFYP; -.
DR   OrthoDB; 5340854at2759; -.
DR   PhylomeDB; B2RXF0; -.
DR   TreeFam; TF336481; -.
DR   PathwayCommons; B2RXF0; -.
DR   BioGRID-ORCS; 730130; 9 hits in 1139 CRISPR screens.
DR   GenomeRNAi; 730130; -.
DR   Pharos; B2RXF0; Tdark.
DR   PRO; PR:B2RXF0; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; B2RXF0; Protein.
DR   Bgee; ENSG00000234224; Expressed in duodenum and 52 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 4.10.20.10; Tat domain; 1.
DR   InterPro; IPR036963; Tat_dom_sf.
DR   PANTHER; PTHR31746; TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER; 1.
DR   PANTHER; PTHR31746:SF2; TRANSMEMBRANE PROTEIN 229A; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..380
FT                   /note="Transmembrane protein 229A"
FT                   /id="PRO_0000391848"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        189
FT                   /note="Missing (in Ref. 3; AAI71809/AAI57829)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   380 AA;  42370 MW;  5D1C52B9AA449F98 CRC64;
     MAGSDVDSEG PARRGGAARR PGAPGGPGSE AAAGCPEPLS TAEAPAESAT LPAWMRLYFY
     GMHGITLDVL VSSARRFARS PDLRMLGFSS PYRCLLHSLT HFALEKVYLQ QRRCPNAFVF
     NFLLYPSAHV GLQTLAGQAL LLSLGGGAGV AVAPGALDLA LQYVLALYHC QVFLKRFLRL
     RYGRQRRRQQ QQQQQQQQQQ RRGALPVPPG ARVPTAAGAR RRRPRGPRGA GGAPSQGLPD
     LPRFLFFGMH GFLDEIFFTF FFNVLGQGDG TTSGHTSLWS FFMYGSCSFV VEKLYFHLHY
     SRGWGTWKRV PIYVIFIYVW ELSWGLGLRT CGACSWDYSH YPLNFMGLIT LMYLPGWIFL
     SVYQDLISNV LWRVQYVPAN
//