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Protein

Transmembrane protein 229A

Gene

TMEM229A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32475-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 229A
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:37279. TMEM229A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000234224.
PharmGKBiPA165618420.

Polymorphism and mutation databases

BioMutaiTMEM229A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003918481 – 380Transmembrane protein 229AAdd BLAST380

Proteomic databases

PaxDbiB2RXF0.
PRIDEiB2RXF0.

PTM databases

PhosphoSitePlusiB2RXF0.

Expressioni

Gene expression databases

BgeeiENSG00000234224.

Organism-specific databases

HPAiHPA056391.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000395244.

Structurei

3D structure databases

ProteinModelPortaliB2RXF0.
SMRiB2RXF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM229 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE68. Eukaryota.
ENOG4110FSQ. LUCA.
GeneTreeiENSGT00390000010899.
HOGENOMiHOG000090241.
HOVERGENiHBG087807.
InParanoidiB2RXF0.
OMAiMRLYFYG.
OrthoDBiEOG091G0CTX.
PhylomeDBiB2RXF0.
TreeFamiTF336481.

Family and domain databases

Gene3Di4.10.20.10. 1 hit.
InterProiIPR001831. IV_Tat.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RXF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSDVDSEG PARRGGAARR PGAPGGPGSE AAAGCPEPLS TAEAPAESAT
60 70 80 90 100
LPAWMRLYFY GMHGITLDVL VSSARRFARS PDLRMLGFSS PYRCLLHSLT
110 120 130 140 150
HFALEKVYLQ QRRCPNAFVF NFLLYPSAHV GLQTLAGQAL LLSLGGGAGV
160 170 180 190 200
AVAPGALDLA LQYVLALYHC QVFLKRFLRL RYGRQRRRQQ QQQQQQQQQQ
210 220 230 240 250
RRGALPVPPG ARVPTAAGAR RRRPRGPRGA GGAPSQGLPD LPRFLFFGMH
260 270 280 290 300
GFLDEIFFTF FFNVLGQGDG TTSGHTSLWS FFMYGSCSFV VEKLYFHLHY
310 320 330 340 350
SRGWGTWKRV PIYVIFIYVW ELSWGLGLRT CGACSWDYSH YPLNFMGLIT
360 370 380
LMYLPGWIFL SVYQDLISNV LWRVQYVPAN
Length:380
Mass (Da):42,370
Last modified:March 2, 2010 - v2
Checksum:i5D1C52B9AA449F98
GO

Sequence cautioni

The sequence EAL24328 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189Missing in AAI71809 (PubMed:15489334).Curated1
Sequence conflicti189Missing in AAI57829 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004690 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24328.1. Sequence problems.
BC157828 mRNA. Translation: AAI57829.1.
BC171809 mRNA. Translation: AAI71809.1.
CCDSiCCDS47694.1.
RefSeqiNP_001129474.1. NM_001136002.1.
UniGeneiHs.450249.

Genome annotation databases

EnsembliENST00000455783; ENSP00000395244; ENSG00000234224.
GeneIDi730130.
KEGGihsa:730130.
UCSCiuc011kob.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004690 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24328.1. Sequence problems.
BC157828 mRNA. Translation: AAI57829.1.
BC171809 mRNA. Translation: AAI71809.1.
CCDSiCCDS47694.1.
RefSeqiNP_001129474.1. NM_001136002.1.
UniGeneiHs.450249.

3D structure databases

ProteinModelPortaliB2RXF0.
SMRiB2RXF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000395244.

PTM databases

PhosphoSitePlusiB2RXF0.

Polymorphism and mutation databases

BioMutaiTMEM229A.

Proteomic databases

PaxDbiB2RXF0.
PRIDEiB2RXF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455783; ENSP00000395244; ENSG00000234224.
GeneIDi730130.
KEGGihsa:730130.
UCSCiuc011kob.3. human.

Organism-specific databases

CTDi730130.
GeneCardsiTMEM229A.
HGNCiHGNC:37279. TMEM229A.
HPAiHPA056391.
neXtProtiNX_B2RXF0.
OpenTargetsiENSG00000234224.
PharmGKBiPA165618420.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE68. Eukaryota.
ENOG4110FSQ. LUCA.
GeneTreeiENSGT00390000010899.
HOGENOMiHOG000090241.
HOVERGENiHBG087807.
InParanoidiB2RXF0.
OMAiMRLYFYG.
OrthoDBiEOG091G0CTX.
PhylomeDBiB2RXF0.
TreeFamiTF336481.

Enzyme and pathway databases

BioCyciZFISH:G66-32475-MONOMER.

Miscellaneous databases

GenomeRNAii730130.
PROiB2RXF0.

Gene expression databases

BgeeiENSG00000234224.

Family and domain databases

Gene3Di4.10.20.10. 1 hit.
InterProiIPR001831. IV_Tat.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT229A_HUMAN
AccessioniPrimary (citable) accession number: B2RXF0
Secondary accession number(s): A4D0X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.