B2RXF0 (T229A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 229A

Gene names

Name:

TMEM229A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM229 family.
Sequence caution	The sequence EAL24328.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Transmembrane protein 229A		PRO_0000391848
Regions
	Transmembrane	51 – 71	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Transmembrane	278 – 298	21	Helical; Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Transmembrane	343 – 363	21	Helical; Potential
Experimental info
	Sequence conflict	189	1	Missing in AAI71809. Ref.3
	Sequence conflict	189	1	Missing in AAI57829. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	B2RXF0 [UniParc]. Last modified March 2, 2010. Version 2. Checksum: 5D1C52B9AA449F98	FASTA	380	42,370
	10 20 30 40 50 60 MAGSDVDSEG PARRGGAARR PGAPGGPGSE AAAGCPEPLS TAEAPAESAT LPAWMRLYFY 70 80 90 100 110 120 GMHGITLDVL VSSARRFARS PDLRMLGFSS PYRCLLHSLT HFALEKVYLQ QRRCPNAFVF 130 140 150 160 170 180 NFLLYPSAHV GLQTLAGQAL LLSLGGGAGV AVAPGALDLA LQYVLALYHC QVFLKRFLRL 190 200 210 220 230 240 RYGRQRRRQQ QQQQQQQQQQ RRGALPVPPG ARVPTAAGAR RRRPRGPRGA GGAPSQGLPD 250 260 270 280 290 300 LPRFLFFGMH GFLDEIFFTF FFNVLGQGDG TTSGHTSLWS FFMYGSCSFV VEKLYFHLHY 310 320 330 340 350 360 SRGWGTWKRV PIYVIFIYVW ELSWGLGLRT CGACSWDYSH YPLNFMGLIT LMYLPGWIFL 370 380 SVYQDLISNV LWRVQYVPAN

References

[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004690 Genomic DNA. No translation available. CH236947 Genomic DNA. Translation: EAL24328.1. Sequence problems. BC157828 mRNA. Translation: AAI57829.1. BC171809 mRNA. Translation: AAI71809.1.
IPI	IPI00927697.
RefSeq	NP_001129474.1. NM_001136002.1.
UniGene	Hs.450249.
3D structure databases
ProteinModelPortal	B2RXF0.
ModBase	Search...
Proteomic databases
PaxDb	B2RXF0.
PRIDE	B2RXF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000455783; ENSP00000395244; ENSG00000234224.
GeneID	730130.
KEGG	hsa:730130.
UCSC	uc011kob.2. human.
Organism-specific databases
CTD	730130.
GeneCards	GC07M123670.
HGNC	HGNC:37279. TMEM229A.
neXtProt	NX_B2RXF0.
PharmGKB	PA165618420.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82302.
HOGENOM	HOG000090241.
HOVERGEN	HBG087807.
OMA	LYFYGMH.
OrthoDB	EOG4Q84XZ.
Gene expression databases
Bgee	B2RXF0.
Family and domain databases
Gene3D	4.10.20.10. 1 hit.
InterPro	IPR001831. IV_Tat. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	730130.
NextBio	132367.

Entry information

Entry name

T229A_HUMAN

Accession

Primary (citable) accession number: B2RXF0
Secondary accession number(s): A4D0X6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 2, 2010
Last sequence update:	March 2, 2010
Last modified:	April 3, 2013
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.