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B2RXF0

- T229A_HUMAN

UniProt

B2RXF0 - T229A_HUMAN

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Protein
Transmembrane protein 229A
Gene
TMEM229A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 229A
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:37279. TMEM229A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei343 – 36321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell nucleus Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Transmembrane protein 229A
PRO_0000391848Add
BLAST

Proteomic databases

PaxDbiB2RXF0.
PRIDEiB2RXF0.

Expressioni

Gene expression databases

BgeeiB2RXF0.

Organism-specific databases

HPAiHPA056391.

Structurei

3D structure databases

ProteinModelPortaliB2RXF0.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM229 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82302.
HOGENOMiHOG000090241.
HOVERGENiHBG087807.
OMAiGMHGITL.
OrthoDBiEOG7PGDR7.
PhylomeDBiB2RXF0.
TreeFamiTF336481.

Family and domain databases

Gene3Di4.10.20.10. 1 hit.
InterProiIPR001831. IV_Tat.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RXF0-1 [UniParc]FASTAAdd to Basket

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MAGSDVDSEG PARRGGAARR PGAPGGPGSE AAAGCPEPLS TAEAPAESAT    50
LPAWMRLYFY GMHGITLDVL VSSARRFARS PDLRMLGFSS PYRCLLHSLT 100
HFALEKVYLQ QRRCPNAFVF NFLLYPSAHV GLQTLAGQAL LLSLGGGAGV 150
AVAPGALDLA LQYVLALYHC QVFLKRFLRL RYGRQRRRQQ QQQQQQQQQQ 200
RRGALPVPPG ARVPTAAGAR RRRPRGPRGA GGAPSQGLPD LPRFLFFGMH 250
GFLDEIFFTF FFNVLGQGDG TTSGHTSLWS FFMYGSCSFV VEKLYFHLHY 300
SRGWGTWKRV PIYVIFIYVW ELSWGLGLRT CGACSWDYSH YPLNFMGLIT 350
LMYLPGWIFL SVYQDLISNV LWRVQYVPAN 380
Length:380
Mass (Da):42,370
Last modified:March 2, 2010 - v2
Checksum:i5D1C52B9AA449F98
GO

Sequence cautioni

The sequence EAL24328.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891Missing in AAI71809. 1 Publication
Sequence conflicti189 – 1891Missing in AAI57829. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004690 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24328.1. Sequence problems.
BC157828 mRNA. Translation: AAI57829.1.
BC171809 mRNA. Translation: AAI71809.1.
CCDSiCCDS47694.1.
RefSeqiNP_001129474.1. NM_001136002.1.
UniGeneiHs.450249.

Genome annotation databases

EnsembliENST00000455783; ENSP00000395244; ENSG00000234224.
GeneIDi730130.
KEGGihsa:730130.
UCSCiuc011kob.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004690 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24328.1 . Sequence problems.
BC157828 mRNA. Translation: AAI57829.1 .
BC171809 mRNA. Translation: AAI71809.1 .
CCDSi CCDS47694.1.
RefSeqi NP_001129474.1. NM_001136002.1.
UniGenei Hs.450249.

3D structure databases

ProteinModelPortali B2RXF0.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi B2RXF0.
PRIDEi B2RXF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000455783 ; ENSP00000395244 ; ENSG00000234224 .
GeneIDi 730130.
KEGGi hsa:730130.
UCSCi uc011kob.2. human.

Organism-specific databases

CTDi 730130.
GeneCardsi GC07M123670.
HGNCi HGNC:37279. TMEM229A.
HPAi HPA056391.
neXtProti NX_B2RXF0.
PharmGKBi PA165618420.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82302.
HOGENOMi HOG000090241.
HOVERGENi HBG087807.
OMAi GMHGITL.
OrthoDBi EOG7PGDR7.
PhylomeDBi B2RXF0.
TreeFami TF336481.

Miscellaneous databases

GenomeRNAii 730130.
NextBioi 132367.
PROi B2RXF0.

Gene expression databases

Bgeei B2RXF0.

Family and domain databases

Gene3Di 4.10.20.10. 1 hit.
InterProi IPR001831. IV_Tat.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiT229A_HUMAN
AccessioniPrimary (citable) accession number: B2RXF0
Secondary accession number(s): A4D0X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: July 9, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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