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B2RXF0 (T229A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 229A
Gene names
Name:TMEM229A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM229 family.

Sequence caution

The sequence EAL24328.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Transmembrane protein 229A
PRO_0000391848

Regions

Transmembrane51 – 7121Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane343 – 36321Helical; Potential

Experimental info

Sequence conflict1891Missing in AAI71809. Ref.3
Sequence conflict1891Missing in AAI57829. Ref.3

Sequences

Sequence LengthMass (Da)Tools
B2RXF0 [UniParc].

Last modified March 2, 2010. Version 2.
Checksum: 5D1C52B9AA449F98

FASTA38042,370
        10         20         30         40         50         60 
MAGSDVDSEG PARRGGAARR PGAPGGPGSE AAAGCPEPLS TAEAPAESAT LPAWMRLYFY 

        70         80         90        100        110        120 
GMHGITLDVL VSSARRFARS PDLRMLGFSS PYRCLLHSLT HFALEKVYLQ QRRCPNAFVF 

       130        140        150        160        170        180 
NFLLYPSAHV GLQTLAGQAL LLSLGGGAGV AVAPGALDLA LQYVLALYHC QVFLKRFLRL 

       190        200        210        220        230        240 
RYGRQRRRQQ QQQQQQQQQQ RRGALPVPPG ARVPTAAGAR RRRPRGPRGA GGAPSQGLPD 

       250        260        270        280        290        300 
LPRFLFFGMH GFLDEIFFTF FFNVLGQGDG TTSGHTSLWS FFMYGSCSFV VEKLYFHLHY 

       310        320        330        340        350        360 
SRGWGTWKRV PIYVIFIYVW ELSWGLGLRT CGACSWDYSH YPLNFMGLIT LMYLPGWIFL 

       370        380 
SVYQDLISNV LWRVQYVPAN 

« Hide

References

[1]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC004690 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24328.1. Sequence problems.
BC157828 mRNA. Translation: AAI57829.1.
BC171809 mRNA. Translation: AAI71809.1.
RefSeqNP_001129474.1. NM_001136002.1.
UniGeneHs.450249.

3D structure databases

ProteinModelPortalB2RXF0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbB2RXF0.
PRIDEB2RXF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000455783; ENSP00000395244; ENSG00000234224.
GeneID730130.
KEGGhsa:730130.
UCSCuc011kob.2. human.

Organism-specific databases

CTD730130.
GeneCardsGC07M123670.
HGNCHGNC:37279. TMEM229A.
HPAHPA056391.
neXtProtNX_B2RXF0.
PharmGKBPA165618420.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82302.
HOGENOMHOG000090241.
HOVERGENHBG087807.
OMAMRLYFYG.
OrthoDBEOG7PGDR7.
PhylomeDBB2RXF0.
TreeFamTF336481.

Gene expression databases

BgeeB2RXF0.

Family and domain databases

Gene3D4.10.20.10. 1 hit.
InterProIPR001831. IV_Tat.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi730130.
NextBio132367.
PROB2RXF0.

Entry information

Entry nameT229A_HUMAN
AccessionPrimary (citable) accession number: B2RXF0
Secondary accession number(s): A4D0X6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 16, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM