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B2RXE2

- B2RXE2_MOUSE

UniProt

B2RXE2 - B2RXE2_MOUSE

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Protein
Sodium/hydrogen exchanger
Gene
Slc9a5, mCG_23530
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sodium:proton antiporter activity Source: InterPro

GO - Biological processi

  1. regulation of pH Source: InterPro
Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotationSAAS annotations, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a5Imported
ORF Names:mCG_23530Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2685542. Slc9a5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriB2RXE2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072893.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiCOG0025.
GeneTreeiENSGT00560000076802.
HOGENOMiHOG000247044.
HOVERGENiHBG052615.
InParanoidiB2RXE2.
KOiK14723.
OMAiKKDGVAN.
OrthoDBiEOG7KQ20Z.
TreeFamiTF317212.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 1 hit.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RXE2-1 [UniParc]FASTAAdd to Basket

« Hide

MLSAALLLLP GLPLAGAGAT EEPTQESGPL GEPPPGLALF RWQWHEVEAP    50
YLVALWILVA SLAKIVFHLS RKVTSLVPES CLLILLGLVL GGIVLAVAKK 100
AEYQLEPGTF FLFLLPPIVL DSGYFMPSRL FFDNLGAILT YAVVGTLWNA 150
FTTGVALWGL QQAGLVAPRV QAGLLDFLLF GSLISAVDPV AVLAVFEEVH 200
VNQTLFIIIF GESLLNDAVT VVLYKVCNSF VEMGSANVQA TDYLKGVASL 250
FVVSLGGAAV GLVFAFLLAL TTRFTKRVRI IEPLLVFLLA YAAYLTAEMA 300
SLSAILAVTM CGLGCKKYVE ANISHKSRTA VKYTMKTLAS CAETVIFMLL 350
GISAVDSSKW AWDSGLVLGT LFFILFFRAL GVVLQTWALN QFRLVPLDKI 400
DQVVMSYGGL RGAVAFALVI LLDRTKVPAK DYFVATTIVV VFFTVIVQGL 450
TIKPLVKWLR VKRSDYHKPT LNQELHEHTF DHILAAVEDV VGHHGYHYWR 500
DRWEQFDKKY LSQLLMRRSA YRIRDQIWDV YYRLNIRDAI SFVDQGGHVL 550
SSTGLTLPSM PSRNSVAETS VTNLLRESGS GACLDLQVID TVRSGRDRED 600
AVMHHLLCGG LYKPRRRYKA SCGRHFISED AQERQDKEIF QQNMKRRLES 650
FKSTKHNICF TKSKPRPRKT SHKKKDGVAN PEATNGKPPR DLGFQDTAAV 700
ILTVESEEEE ESDSSETEKE DDEGIIFVAR ATSEVLQEGK VSGSLEVCPS 750
PRIIPPSPTC AEKELPWKSG QGDLAVYVSS ETTKIVPVDM QTGWNQSISS 800
LESLASPPCT QPPTLTRLPP HPLVTEEPQV PIDLSSDPRS SFAFPPSLAK 850
AGRSRSESSA DIPQQELQPL MGHKDHTHLS PGTANSHWCI QFNRGGRL 898
Length:898
Mass (Da):99,009
Last modified:July 1, 2008 - v1
Checksum:iAE5BBB8A4426BB42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124584 Genomic DNA. No translation available.
BC151197 mRNA. Translation: AAI51198.1.
CH466525 Genomic DNA. Translation: EDL11276.1.
RefSeqiNP_001074801.1. NM_001081332.1.
UniGeneiMm.334766.

Genome annotation databases

EnsembliENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786.
GeneIDi277973.
KEGGimmu:277973.
UCSCiuc009ncu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC124584 Genomic DNA. No translation available.
BC151197 mRNA. Translation: AAI51198.1 .
CH466525 Genomic DNA. Translation: EDL11276.1 .
RefSeqi NP_001074801.1. NM_001081332.1.
UniGenei Mm.334766.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000072893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073149 ; ENSMUSP00000072893 ; ENSMUSG00000014786 .
GeneIDi 277973.
KEGGi mmu:277973.
UCSCi uc009ncu.1. mouse.

Organism-specific databases

CTDi 6553.
MGIi MGI:2685542. Slc9a5.

Phylogenomic databases

eggNOGi COG0025.
GeneTreei ENSGT00560000076802.
HOGENOMi HOG000247044.
HOVERGENi HBG052615.
InParanoidi B2RXE2.
KOi K14723.
OMAi KKDGVAN.
OrthoDBi EOG7KQ20Z.
TreeFami TF317212.

Miscellaneous databases

NextBioi 393862.
PROi B2RXE2.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RXE2.

Family and domain databases

InterProi IPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view ]
PANTHERi PTHR10110. PTHR10110. 1 hit.
Pfami PF00999. Na_H_Exchanger. 1 hit.
[Graphical view ]
PRINTSi PR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RXE2_MOUSE
AccessioniPrimary (citable) accession number: B2RXE2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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