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B2RXE2

- B2RXE2_MOUSE

UniProt

B2RXE2 - B2RXE2_MOUSE

Protein

Sodium/hydrogen exchanger

Gene

Slc9a5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sodium:proton antiporter activity Source: InterPro

    GO - Biological processi

    1. regulation of pH Source: InterPro

    Keywords - Biological processi

    AntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/hydrogen exchangerUniRule annotation
    Gene namesi
    Name:Slc9a5Imported
    ORF Names:mCG_23530Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2685542. Slc9a5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriB2RXE2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000072893.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0025.
    GeneTreeiENSGT00560000076802.
    HOGENOMiHOG000247044.
    HOVERGENiHBG052615.
    InParanoidiB2RXE2.
    KOiK14723.
    OMAiKKDGVAN.
    OrthoDBiEOG7KQ20Z.
    TreeFamiTF317212.

    Family and domain databases

    InterProiIPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR018410. Na/H_exchanger_3/5.
    IPR004709. NaH_exchanger.
    [Graphical view]
    PANTHERiPTHR10110. PTHR10110. 1 hit.
    PfamiPF00999. Na_H_Exchanger. 1 hit.
    [Graphical view]
    PRINTSiPR01084. NAHEXCHNGR.
    PR01087. NAHEXCHNGR3.
    TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B2RXE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSAALLLLP GLPLAGAGAT EEPTQESGPL GEPPPGLALF RWQWHEVEAP    50
    YLVALWILVA SLAKIVFHLS RKVTSLVPES CLLILLGLVL GGIVLAVAKK 100
    AEYQLEPGTF FLFLLPPIVL DSGYFMPSRL FFDNLGAILT YAVVGTLWNA 150
    FTTGVALWGL QQAGLVAPRV QAGLLDFLLF GSLISAVDPV AVLAVFEEVH 200
    VNQTLFIIIF GESLLNDAVT VVLYKVCNSF VEMGSANVQA TDYLKGVASL 250
    FVVSLGGAAV GLVFAFLLAL TTRFTKRVRI IEPLLVFLLA YAAYLTAEMA 300
    SLSAILAVTM CGLGCKKYVE ANISHKSRTA VKYTMKTLAS CAETVIFMLL 350
    GISAVDSSKW AWDSGLVLGT LFFILFFRAL GVVLQTWALN QFRLVPLDKI 400
    DQVVMSYGGL RGAVAFALVI LLDRTKVPAK DYFVATTIVV VFFTVIVQGL 450
    TIKPLVKWLR VKRSDYHKPT LNQELHEHTF DHILAAVEDV VGHHGYHYWR 500
    DRWEQFDKKY LSQLLMRRSA YRIRDQIWDV YYRLNIRDAI SFVDQGGHVL 550
    SSTGLTLPSM PSRNSVAETS VTNLLRESGS GACLDLQVID TVRSGRDRED 600
    AVMHHLLCGG LYKPRRRYKA SCGRHFISED AQERQDKEIF QQNMKRRLES 650
    FKSTKHNICF TKSKPRPRKT SHKKKDGVAN PEATNGKPPR DLGFQDTAAV 700
    ILTVESEEEE ESDSSETEKE DDEGIIFVAR ATSEVLQEGK VSGSLEVCPS 750
    PRIIPPSPTC AEKELPWKSG QGDLAVYVSS ETTKIVPVDM QTGWNQSISS 800
    LESLASPPCT QPPTLTRLPP HPLVTEEPQV PIDLSSDPRS SFAFPPSLAK 850
    AGRSRSESSA DIPQQELQPL MGHKDHTHLS PGTANSHWCI QFNRGGRL 898
    Length:898
    Mass (Da):99,009
    Last modified:July 1, 2008 - v1
    Checksum:iAE5BBB8A4426BB42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124584 Genomic DNA. No translation available.
    BC151197 mRNA. Translation: AAI51198.1.
    CH466525 Genomic DNA. Translation: EDL11276.1.
    RefSeqiNP_001074801.1. NM_001081332.1.
    UniGeneiMm.334766.

    Genome annotation databases

    EnsembliENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786.
    GeneIDi277973.
    KEGGimmu:277973.
    UCSCiuc009ncu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC124584 Genomic DNA. No translation available.
    BC151197 mRNA. Translation: AAI51198.1 .
    CH466525 Genomic DNA. Translation: EDL11276.1 .
    RefSeqi NP_001074801.1. NM_001081332.1.
    UniGenei Mm.334766.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000072893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073149 ; ENSMUSP00000072893 ; ENSMUSG00000014786 .
    GeneIDi 277973.
    KEGGi mmu:277973.
    UCSCi uc009ncu.1. mouse.

    Organism-specific databases

    CTDi 6553.
    MGIi MGI:2685542. Slc9a5.

    Phylogenomic databases

    eggNOGi COG0025.
    GeneTreei ENSGT00560000076802.
    HOGENOMi HOG000247044.
    HOVERGENi HBG052615.
    InParanoidi B2RXE2.
    KOi K14723.
    OMAi KKDGVAN.
    OrthoDBi EOG7KQ20Z.
    TreeFami TF317212.

    Miscellaneous databases

    NextBioi 393862.
    PROi B2RXE2.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori B2RXE2.

    Family and domain databases

    InterProi IPR006153. Cation/H_exchanger.
    IPR018422. Cation/H_exchanger_CPA1.
    IPR018410. Na/H_exchanger_3/5.
    IPR004709. NaH_exchanger.
    [Graphical view ]
    PANTHERi PTHR10110. PTHR10110. 1 hit.
    Pfami PF00999. Na_H_Exchanger. 1 hit.
    [Graphical view ]
    PRINTSi PR01084. NAHEXCHNGR.
    PR01087. NAHEXCHNGR3.
    TIGRFAMsi TIGR00840. b_cpa1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB2RXE2_MOUSE
    AccessioniPrimary (citable) accession number: B2RXE2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3