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B2RXE2 (B2RXE2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Sodium/hydrogen exchanger RuleBase RU003722
Gene names
Name:Slc9a5 MGI 2685542 EMBL AAI51198.1 Ensembl ENSMUSP00000072893
ORF Names:mCG_23530 EMBL EDL11276.1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length898 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Biological processAntiport RuleBase RU003722
Ion transport
Sodium transport SAAS SAAS006153 RuleBase RU003722
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS018422
   LigandSodium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of pH

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsodium:hydrogen antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B2RXE2 [UniParc].

Last modified July 1, 2008. Version 1.
Checksum: AE5BBB8A4426BB42

FASTA89899,009
        10         20         30         40         50         60 
MLSAALLLLP GLPLAGAGAT EEPTQESGPL GEPPPGLALF RWQWHEVEAP YLVALWILVA 

        70         80         90        100        110        120 
SLAKIVFHLS RKVTSLVPES CLLILLGLVL GGIVLAVAKK AEYQLEPGTF FLFLLPPIVL 

       130        140        150        160        170        180 
DSGYFMPSRL FFDNLGAILT YAVVGTLWNA FTTGVALWGL QQAGLVAPRV QAGLLDFLLF 

       190        200        210        220        230        240 
GSLISAVDPV AVLAVFEEVH VNQTLFIIIF GESLLNDAVT VVLYKVCNSF VEMGSANVQA 

       250        260        270        280        290        300 
TDYLKGVASL FVVSLGGAAV GLVFAFLLAL TTRFTKRVRI IEPLLVFLLA YAAYLTAEMA 

       310        320        330        340        350        360 
SLSAILAVTM CGLGCKKYVE ANISHKSRTA VKYTMKTLAS CAETVIFMLL GISAVDSSKW 

       370        380        390        400        410        420 
AWDSGLVLGT LFFILFFRAL GVVLQTWALN QFRLVPLDKI DQVVMSYGGL RGAVAFALVI 

       430        440        450        460        470        480 
LLDRTKVPAK DYFVATTIVV VFFTVIVQGL TIKPLVKWLR VKRSDYHKPT LNQELHEHTF 

       490        500        510        520        530        540 
DHILAAVEDV VGHHGYHYWR DRWEQFDKKY LSQLLMRRSA YRIRDQIWDV YYRLNIRDAI 

       550        560        570        580        590        600 
SFVDQGGHVL SSTGLTLPSM PSRNSVAETS VTNLLRESGS GACLDLQVID TVRSGRDRED 

       610        620        630        640        650        660 
AVMHHLLCGG LYKPRRRYKA SCGRHFISED AQERQDKEIF QQNMKRRLES FKSTKHNICF 

       670        680        690        700        710        720 
TKSKPRPRKT SHKKKDGVAN PEATNGKPPR DLGFQDTAAV ILTVESEEEE ESDSSETEKE 

       730        740        750        760        770        780 
DDEGIIFVAR ATSEVLQEGK VSGSLEVCPS PRIIPPSPTC AEKELPWKSG QGDLAVYVSS 

       790        800        810        820        830        840 
ETTKIVPVDM QTGWNQSISS LESLASPPCT QPPTLTRLPP HPLVTEEPQV PIDLSSDPRS 

       850        860        870        880        890 
SFAFPPSLAK AGRSRSESSA DIPQQELQPL MGHKDHTHLS PGTANSHWCI QFNRGGRL

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL11276.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI51198.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL11276.1.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000072893.
[5]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000072893.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC124584 Genomic DNA. No translation available.
BC151197 mRNA. Translation: AAI51198.1.
CH466525 Genomic DNA. Translation: EDL11276.1.
IPIIPI00466275.
RefSeqNP_001074801.1. NM_001081332.1.
UniGeneMm.334766.

3D structure databases

SMRB2RXE2. Positions 176-203, 602-649.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786.
GeneID277973.
KEGGmmu:277973.
UCSCuc009ncu.1. mouse.

Organism-specific databases

CTD6553.
MGIMGI:2685542. Slc9a5.

Phylogenomic databases

eggNOGCOG0025.
GeneTreeENSGT00560000076802.
HOGENOMHOG000247044.
HOVERGENHBG052615.
InParanoidB2RXE2.
KOK14723.
OMASHKSRTT.
OrthoDBEOG4HQDHQ.

Gene expression databases

GenevestigatorB2RXE2.

Family and domain databases

InterProIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERPTHR10110. PTHR10110. 1 hit.
PTHR10110:SF10. PTHR10110:SF10. 1 hit.
PfamPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsTIGR00840. b_cpa1. 1 hit.
ProtoNetSearch...

Other

NextBio393862.
SOURCESearch...

Entry information

Entry nameB2RXE2_MOUSE
AccessionPrimary (citable) accession number: B2RXE2
Entry history
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info