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Protein

Sodium/hydrogen exchanger

Gene

Slc9a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

AntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a5Imported
ORF Names:mCG_23530Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2685542. Slc9a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Transmembranei81 – 9818HelicalSequence analysisAdd
BLAST
Transmembranei138 – 16023HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19625HelicalSequence analysisAdd
BLAST
Transmembranei205 – 22622HelicalSequence analysisAdd
BLAST
Transmembranei246 – 27025HelicalSequence analysisAdd
BLAST
Transmembranei367 – 38822HelicalSequence analysisAdd
BLAST
Transmembranei400 – 42021HelicalSequence analysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 898879Sodium/hydrogen exchangerSequence analysisPRO_5007306670Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 458405Na_H_ExchangerInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1966. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000247044.
HOVERGENiHBG052615.
KOiK14723.
OMAiIPQQQEL.
OrthoDBiEOG7KQ20Z.
TreeFamiTF317212.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 3 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RXE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAALLLLP GLPLAGAGAT EEPTQESGPL GEPPPGLALF RWQWHEVEAP
60 70 80 90 100
YLVALWILVA SLAKIVFHLS RKVTSLVPES CLLILLGLVL GGIVLAVAKK
110 120 130 140 150
AEYQLEPGTF FLFLLPPIVL DSGYFMPSRL FFDNLGAILT YAVVGTLWNA
160 170 180 190 200
FTTGVALWGL QQAGLVAPRV QAGLLDFLLF GSLISAVDPV AVLAVFEEVH
210 220 230 240 250
VNQTLFIIIF GESLLNDAVT VVLYKVCNSF VEMGSANVQA TDYLKGVASL
260 270 280 290 300
FVVSLGGAAV GLVFAFLLAL TTRFTKRVRI IEPLLVFLLA YAAYLTAEMA
310 320 330 340 350
SLSAILAVTM CGLGCKKYVE ANISHKSRTA VKYTMKTLAS CAETVIFMLL
360 370 380 390 400
GISAVDSSKW AWDSGLVLGT LFFILFFRAL GVVLQTWALN QFRLVPLDKI
410 420 430 440 450
DQVVMSYGGL RGAVAFALVI LLDRTKVPAK DYFVATTIVV VFFTVIVQGL
460 470 480 490 500
TIKPLVKWLR VKRSDYHKPT LNQELHEHTF DHILAAVEDV VGHHGYHYWR
510 520 530 540 550
DRWEQFDKKY LSQLLMRRSA YRIRDQIWDV YYRLNIRDAI SFVDQGGHVL
560 570 580 590 600
SSTGLTLPSM PSRNSVAETS VTNLLRESGS GACLDLQVID TVRSGRDRED
610 620 630 640 650
AVMHHLLCGG LYKPRRRYKA SCGRHFISED AQERQDKEIF QQNMKRRLES
660 670 680 690 700
FKSTKHNICF TKSKPRPRKT SHKKKDGVAN PEATNGKPPR DLGFQDTAAV
710 720 730 740 750
ILTVESEEEE ESDSSETEKE DDEGIIFVAR ATSEVLQEGK VSGSLEVCPS
760 770 780 790 800
PRIIPPSPTC AEKELPWKSG QGDLAVYVSS ETTKIVPVDM QTGWNQSISS
810 820 830 840 850
LESLASPPCT QPPTLTRLPP HPLVTEEPQV PIDLSSDPRS SFAFPPSLAK
860 870 880 890
AGRSRSESSA DIPQQELQPL MGHKDHTHLS PGTANSHWCI QFNRGGRL
Length:898
Mass (Da):99,009
Last modified:July 1, 2008 - v1
Checksum:iAE5BBB8A4426BB42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124584 Genomic DNA. No translation available.
BC151197 mRNA. Translation: AAI51198.1.
CH466525 Genomic DNA. Translation: EDL11276.1.
RefSeqiNP_001074801.1. NM_001081332.1.
UniGeneiMm.334766.

Genome annotation databases

EnsembliENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786.
GeneIDi277973.
KEGGimmu:277973.
UCSCiuc009ncu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124584 Genomic DNA. No translation available.
BC151197 mRNA. Translation: AAI51198.1.
CH466525 Genomic DNA. Translation: EDL11276.1.
RefSeqiNP_001074801.1. NM_001081332.1.
UniGeneiMm.334766.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072893.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786.
GeneIDi277973.
KEGGimmu:277973.
UCSCiuc009ncu.1. mouse.

Organism-specific databases

CTDi6553.
MGIiMGI:2685542. Slc9a5.

Phylogenomic databases

eggNOGiKOG1966. Eukaryota.
COG0025. LUCA.
GeneTreeiENSGT00760000119074.
HOGENOMiHOG000247044.
HOVERGENiHBG052615.
KOiK14723.
OMAiIPQQQEL.
OrthoDBiEOG7KQ20Z.
TreeFamiTF317212.

Enzyme and pathway databases

ReactomeiR-MMU-425986. Sodium/Proton exchangers.

Miscellaneous databases

ChiTaRSiSlc9a5. mouse.
SOURCEiSearch...

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
IPR018422. Cation/H_exchanger_CPA1.
IPR018410. Na/H_exchanger_3/5.
IPR004709. NaH_exchanger.
[Graphical view]
PANTHERiPTHR10110. PTHR10110. 3 hits.
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
PRINTSiPR01084. NAHEXCHNGR.
PR01087. NAHEXCHNGR3.
TIGRFAMsiTIGR00840. b_cpa1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RXE2_MOUSE
AccessioniPrimary (citable) accession number: B2RXE2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.