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Protein
Submitted name:

Cytochrome P450, family 26, subfamily c, polypeptide 1

Gene

Cyp26c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • central nervous system development Source: MGI
  • neural crest cell development Source: MGI
  • organelle fusion Source: MGI
  • oxidation-reduction process Source: MGI
  • retinoic acid catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_310468. RA biosynthesis pathway.
REACT_315248. Vitamins.

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450, family 26, subfamily c, polypeptide 1Imported
Submitted name:
Protein Cyp26c1Imported
Gene namesi
Name:Cyp26c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2679699. Cyp26c1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073105.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00800000124060.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
KOiK12665.
OMAiHAICATI.
OrthoDBiEOG7F24SP.
TreeFamiTF105093.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RXA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISWGLSCLS VLGAAGTTLL CAGLLLGLAQ QLWTLRWTLS RDWASTLPLP
60 70 80 90 100
KGSMGWPFFG ETLHWLVQGS RFHSSRRERY GTVFKTHLLG RPVIRVSGAE
110 120 130 140 150
NVRTILLGEH RLVRSQWPQS AHILLGSHTL LGAVGEPHRQ RRKVLARVFS
160 170 180 190 200
RSSLEQFVPR LQGALRREVR SWCAAQRPVA VYQAAKALTF RMAARILLGL
210 220 230 240 250
QLDEARCTEL AHTFEQLVEN LFSLPLDVPF SGLRKGIRAR DQLYEHLDEA
260 270 280 290 300
VAEKLQEKQT AEPGDALLLI INSARELGHE PSVQELKELA VELLFAAFFT
310 320 330 340 350
TASASTSLIL LLLQHPAAIT KIQQELSAQG LGRACTCTPR ASGSPPDCGC
360 370 380 390 400
EPDLSLAMLG RLRYVDCVVK EVLRLLPPVS GGYRTALRTF ELDGYQIPKG
410 420 430 440 450
WSVMYSIRDT HETAAVYRSP PEGFDPERFG VESGDARGSG GRFHYIPFGG
460 470 480 490 500
GARSCLGQEL AQAVLQLLAV ELVRTARWEL ATPAFPVMQT VPIVHPVDGL
510
LLFFHPLPTS GAGDGLPF
Length:518
Mass (Da):57,026
Last modified:July 1, 2008 - v1
Checksum:i0A78D11F556AF618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110212 Genomic DNA. No translation available.
BC151098 mRNA. Translation: AAI51099.1.
BC151106 mRNA. Translation: AAI51107.1.
RefSeqiNP_001098671.1. NM_001105201.1.
UniGeneiMm.457750.

Genome annotation databases

EnsembliENSMUST00000073391; ENSMUSP00000073105; ENSMUSG00000062432.
GeneIDi546726.
KEGGimmu:546726.
UCSCiuc012ble.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110212 Genomic DNA. No translation available.
BC151098 mRNA. Translation: AAI51099.1.
BC151106 mRNA. Translation: AAI51107.1.
RefSeqiNP_001098671.1. NM_001105201.1.
UniGeneiMm.457750.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073391; ENSMUSP00000073105; ENSMUSG00000062432.
GeneIDi546726.
KEGGimmu:546726.
UCSCiuc012ble.1. mouse.

Organism-specific databases

CTDi340665.
MGIiMGI:2679699. Cyp26c1.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00800000124060.
HOGENOMiHOG000220829.
HOVERGENiHBG051099.
KOiK12665.
OMAiHAICATI.
OrthoDBiEOG7F24SP.
TreeFamiTF105093.

Enzyme and pathway databases

ReactomeiREACT_310468. RA biosynthesis pathway.
REACT_315248. Vitamins.

Miscellaneous databases

NextBioi413785.
PROiB2RXA7.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported and TesticleImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RXA7_MOUSE
AccessioniPrimary (citable) accession number: B2RXA7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 22, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.