UniProtKB - B2RX82 (B2RX82_MOUSE)
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Protein
Submitted name:
Cholinergic receptor, nicotinic, alpha polypeptide 10
Gene
Chrna10
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- acetylcholine-gated cation-selective channel activity Source: MGI
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- detection of mechanical stimulus involved in sensory perception of sound Source: MGI
- inner ear morphogenesis Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- synaptic transmission, cholinergic Source: MGI
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Cholinergic receptor, nicotinic, alpha polypeptide 10ImportedSubmitted name: MCG6769, isoform CRA_aImported |
Gene namesi | Name:Chrna10Imported ORF Names:mCG_6769Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3609260. Chrna10. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 236 – 258 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 270 – 289 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 301 – 320 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 426 – 446 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5014084921 | 25 – 447 | Sequence analysisAdd BLAST | 423 |
Keywords - PTMi
Disulfide bondSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 235 | Neur_chan_LBDInterPro annotationAdd BLAST | 205 | |
Domaini | 243 – 357 | Neur_chan_membInterPro annotationAdd BLAST | 115 |
Sequence similaritiesi
Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG3645. Eukaryota. ENOG410XQGR. LUCA. |
GeneTreei | ENSGT00760000118930. |
HOGENOMi | HOG000006756. |
HOVERGENi | HBG003756. |
KOi | K04811. |
OMAi | AQRCHED. |
OrthoDBi | EOG091G0R20. |
TreeFami | TF315605. |
Family and domain databases
Gene3Di | 2.70.170.10. 1 hit. |
InterProi | View protein in InterPro IPR006202. Neur_chan_lig-bd. IPR036734. Neur_chan_lig-bd_sf. IPR006201. Neur_channel. IPR036719. Neuro-gated_channel_TM_sf. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. |
PANTHERi | PTHR18945. PTHR18945. 2 hits. |
Pfami | View protein in Pfam PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. |
PRINTSi | PR00254. NICOTINICR. PR00252. NRIONCHANNEL. |
SUPFAMi | SSF63712. SSF63712. 1 hit. SSF90112. SSF90112. 1 hit. |
TIGRFAMsi | TIGR00860. LIC. 1 hit. |
PROSITEi | View protein in PROSITE PS00236. NEUROTR_ION_CHANNEL. 1 hit. |
i Sequence
Sequence statusi: Complete.
B2RX82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTRSHHLGP GFLLLLFLPA ECLGAEGRLA HKLFRDLFAN YTSALRPVAD
60 70 80 90 100
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LHWDPKAYGD
110 120 130 140 150
LDAIRIPSSL VWRPDIVLYN KADTQPPASA STNVVVRHDG AVRWDAPAIT
160 170 180 190 200
RSSCRVDVSA FPFDAQRCGL TFGSWTHGGH QLDVRPRGTS ASLADFVENV
210 220 230 240 250
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVFI
260 270 280 290 300
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLILAESMP PAESVPLIGK
310 320 330 340 350
YYMATMTMVT FSTALTILIM NLHYCGPNAH PVPAWARVLL LGHLAKGLCV
360 370 380 390 400
RERGEPCGQS KPLESAPSLQ PPAGPPAGPC HEPRCLCHQE ALLHHVASIA
410 420 430 440
GTFRSHRAAQ RRHEDWKRLA RVMDRFFLGI FFCMALVMSL LVLVQAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC118592 Genomic DNA. No translation available. AC132297 Genomic DNA. No translation available. BC147245 mRNA. Translation: AAI47246.1. BC147246 mRNA. Translation: AAI47247.1. BC151033 mRNA. Translation: AAI51034.1. BC151035 mRNA. Translation: AAI51036.1. CH466531 Genomic DNA. Translation: EDL16580.1. CH466531 Genomic DNA. Translation: EDL16581.1. |
RefSeqi | NP_001074893.1. NM_001081424.1. XP_006508071.1. XM_006508008.3. XP_006508072.1. XM_006508009.2. |
UniGenei | Mm.334074. |
Genome annotation databases
Ensembli | ENSMUST00000084830; ENSMUSP00000081891; ENSMUSG00000066279. |
GeneIDi | 504186. |
KEGGi | mmu:504186. |
UCSCi | uc009iqw.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | B2RX82_MOUSE | |
Accessioni | B2RX82Primary (citable) accession number: B2RX82 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | March 28, 2018 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |