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Protein
Submitted name:

Cholinergic receptor, nicotinic, alpha polypeptide 10

Gene

Chrna10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: MGI
  • acetylcholine binding Source: GO_Central

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  • inner ear morphogenesis Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • signal transduction Source: GOC
  • synaptic transmission, cholinergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor, nicotinic, alpha polypeptide 10Imported
Submitted name:
MCG6769, isoform CRA_aImported
Submitted name:
Protein Chrna10Imported
Gene namesi
Name:Chrna10Imported
ORF Names:mCG_6769Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3609260. Chrna10.

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei236 – 258HelicalSequence analysisAdd BLAST23
Transmembranei270 – 289HelicalSequence analysisAdd BLAST20
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500875529125 – 447Sequence analysisAdd BLAST423

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000066279.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081891.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 235Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini243 – 357Neur_chan_membInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
KOiK04811.
OMAiAQRCHED.
OrthoDBiEOG091G0R20.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RX82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRSHHLGP GFLLLLFLPA ECLGAEGRLA HKLFRDLFAN YTSALRPVAD
60 70 80 90 100
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LHWDPKAYGD
110 120 130 140 150
LDAIRIPSSL VWRPDIVLYN KADTQPPASA STNVVVRHDG AVRWDAPAIT
160 170 180 190 200
RSSCRVDVSA FPFDAQRCGL TFGSWTHGGH QLDVRPRGTS ASLADFVENV
210 220 230 240 250
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVFI
260 270 280 290 300
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLILAESMP PAESVPLIGK
310 320 330 340 350
YYMATMTMVT FSTALTILIM NLHYCGPNAH PVPAWARVLL LGHLAKGLCV
360 370 380 390 400
RERGEPCGQS KPLESAPSLQ PPAGPPAGPC HEPRCLCHQE ALLHHVASIA
410 420 430 440
GTFRSHRAAQ RRHEDWKRLA RVMDRFFLGI FFCMALVMSL LVLVQAL
Length:447
Mass (Da):49,577
Last modified:July 1, 2008 - v1
Checksum:i24B39F5EDD679C3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118592 Genomic DNA. No translation available.
AC132297 Genomic DNA. No translation available.
BC147245 mRNA. Translation: AAI47246.1.
BC147246 mRNA. Translation: AAI47247.1.
BC151033 mRNA. Translation: AAI51034.1.
BC151035 mRNA. Translation: AAI51036.1.
CH466531 Genomic DNA. Translation: EDL16580.1.
CH466531 Genomic DNA. Translation: EDL16581.1.
RefSeqiNP_001074893.1. NM_001081424.1.
XP_006508071.1. XM_006508008.3.
XP_006508072.1. XM_006508009.2.
UniGeneiMm.334074.

Genome annotation databases

EnsembliENSMUST00000084830; ENSMUSP00000081891; ENSMUSG00000066279.
GeneIDi504186.
KEGGimmu:504186.
UCSCiuc009iqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118592 Genomic DNA. No translation available.
AC132297 Genomic DNA. No translation available.
BC147245 mRNA. Translation: AAI47246.1.
BC147246 mRNA. Translation: AAI47247.1.
BC151033 mRNA. Translation: AAI51034.1.
BC151035 mRNA. Translation: AAI51036.1.
CH466531 Genomic DNA. Translation: EDL16580.1.
CH466531 Genomic DNA. Translation: EDL16581.1.
RefSeqiNP_001074893.1. NM_001081424.1.
XP_006508071.1. XM_006508008.3.
XP_006508072.1. XM_006508009.2.
UniGeneiMm.334074.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084830; ENSMUSP00000081891; ENSMUSG00000066279.
GeneIDi504186.
KEGGimmu:504186.
UCSCiuc009iqw.1. mouse.

Organism-specific databases

CTDi57053.
MGIiMGI:3609260. Chrna10.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
KOiK04811.
OMAiAQRCHED.
OrthoDBiEOG091G0R20.
TreeFamiTF315605.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066279.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2RX82_MOUSE
AccessioniPrimary (citable) accession number: B2RX82
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.