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B2RX82

- B2RX82_MOUSE

UniProt

B2RX82 - B2RX82_MOUSE

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Protein
Submitted name: Cholinergic receptor, nicotinic, alpha polypeptide 10
Gene
Chrna10, mCG_6769
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: MGI

GO - Biological processi

  1. cation transport Source: GOC
  2. detection of mechanical stimulus involved in sensory perception of sound Source: MGI
  3. inner ear morphogenesis Source: MGI
  4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  5. synaptic transmission, cholinergic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotations, ReceptorSAAS annotationsImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor, nicotinic, alpha polypeptide 10Imported
Submitted name:
MCG6769, isoform CRA_aImported
Submitted name:
Protein Chrna10Imported
Gene namesi
Name:Chrna10Imported
ORF Names:mCG_6769Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:3609260. Chrna10.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. perikaryon Source: Ensembl
  5. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotations, Membrane, Postsynaptic cell membraneSAAS annotations, Synapse

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriB2RX82.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081891.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

eggNOGiNOG306809.
GeneTreeiENSGT00740000115103.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiB2RX82.
KOiK04811.
OMAiDGAVRWD.
OrthoDBiEOG72JWGV.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RX82-1 [UniParc]FASTAAdd to Basket

« Hide

MGTRSHHLGP GFLLLLFLPA ECLGAEGRLA HKLFRDLFAN YTSALRPVAD    50
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LHWDPKAYGD 100
LDAIRIPSSL VWRPDIVLYN KADTQPPASA STNVVVRHDG AVRWDAPAIT 150
RSSCRVDVSA FPFDAQRCGL TFGSWTHGGH QLDVRPRGTS ASLADFVENV 200
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVFI 250
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLILAESMP PAESVPLIGK 300
YYMATMTMVT FSTALTILIM NLHYCGPNAH PVPAWARVLL LGHLAKGLCV 350
RERGEPCGQS KPLESAPSLQ PPAGPPAGPC HEPRCLCHQE ALLHHVASIA 400
GTFRSHRAAQ RRHEDWKRLA RVMDRFFLGI FFCMALVMSL LVLVQAL 447
Length:447
Mass (Da):49,577
Last modified:July 1, 2008 - v1
Checksum:i24B39F5EDD679C3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC118592 Genomic DNA. No translation available.
AC132297 Genomic DNA. No translation available.
BC147245 mRNA. Translation: AAI47246.1.
BC147246 mRNA. Translation: AAI47247.1.
BC151033 mRNA. Translation: AAI51034.1.
BC151035 mRNA. Translation: AAI51036.1.
CH466531 Genomic DNA. Translation: EDL16580.1.
CH466531 Genomic DNA. Translation: EDL16581.1.
RefSeqiNP_001074893.1. NM_001081424.1.
XP_006508071.1. XM_006508008.1.
XP_006508072.1. XM_006508009.1.
UniGeneiMm.334074.

Genome annotation databases

EnsembliENSMUST00000084830; ENSMUSP00000081891; ENSMUSG00000066279.
GeneIDi504186.
KEGGimmu:504186.
UCSCiuc009iqw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC118592 Genomic DNA. No translation available.
AC132297 Genomic DNA. No translation available.
BC147245 mRNA. Translation: AAI47246.1 .
BC147246 mRNA. Translation: AAI47247.1 .
BC151033 mRNA. Translation: AAI51034.1 .
BC151035 mRNA. Translation: AAI51036.1 .
CH466531 Genomic DNA. Translation: EDL16580.1 .
CH466531 Genomic DNA. Translation: EDL16581.1 .
RefSeqi NP_001074893.1. NM_001081424.1.
XP_006508071.1. XM_006508008.1.
XP_006508072.1. XM_006508009.1.
UniGenei Mm.334074.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084830 ; ENSMUSP00000081891 ; ENSMUSG00000066279 .
GeneIDi 504186.
KEGGi mmu:504186.
UCSCi uc009iqw.1. mouse.

Organism-specific databases

CTDi 57053.
MGIi MGI:3609260. Chrna10.

Phylogenomic databases

eggNOGi NOG306809.
GeneTreei ENSGT00740000115103.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
InParanoidi B2RX82.
KOi K04811.
OMAi DGAVRWD.
OrthoDBi EOG72JWGV.
TreeFami TF315605.

Miscellaneous databases

NextBioi 411884.
PROi B2RX82.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RX82.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RX82_MOUSE
AccessioniPrimary (citable) accession number: B2RX82
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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