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B2RX12

- MRP3_MOUSE

UniProt

B2RX12 - MRP3_MOUSE

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Protein
Canalicular multispecific organic anion transporter 2
Gene
Abcc3, Cmoat2, Mrp3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi660 – 6678ATP 1 Reviewed prediction
Nucleotide bindingi1319 – 13268ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 2
Alternative name(s):
ATP-binding cassette sub-family C member 3
Multidrug resistance-associated protein 3
Gene namesi
Name:Abcc3
Synonyms:Cmoat2, Mrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1923658. Abcc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed prediction
Add
BLAST
Transmembranei36 – 5621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini57 – 7519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei76 – 9621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini97 – 1026Extracellular Reviewed prediction
Transmembranei103 – 12321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini124 – 1296Cytoplasmic Reviewed prediction
Transmembranei130 – 15021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini151 – 17020Extracellular Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini192 – 301110Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei302 – 32423Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini325 – 34521Extracellular Reviewed prediction
Add
BLAST
Transmembranei346 – 36621Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini367 – 41953Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei420 – 44021Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini441 – 4411Extracellular Reviewed prediction
Transmembranei442 – 46221Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini463 – 53573Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei536 – 55621Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini557 – 56711Extracellular Reviewed prediction
Add
BLAST
Transmembranei568 – 58821Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini589 – 967379Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei968 – 98821Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini989 – 101325Extracellular Reviewed prediction
Add
BLAST
Transmembranei1014 – 103421Helical; Name=13; Reviewed prediction
Add
BLAST
Topological domaini1035 – 107137Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1072 – 109221Helical; Name=14; Reviewed prediction
Add
BLAST
Topological domaini1093 – 10964Extracellular Reviewed prediction
Transmembranei1097 – 111721Helical; Name=15; Reviewed prediction
Add
BLAST
Topological domaini1118 – 119174Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1192 – 121221Helical; Name=16; Reviewed prediction
Add
BLAST
Topological domaini1213 – 12197Extracellular Reviewed prediction
Transmembranei1220 – 124021Helical; Name=17; Reviewed prediction
Add
BLAST
Topological domaini1241 – 1523283Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15231523Canalicular multispecific organic anion transporter 2
PRO_0000356238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1002 – 10021N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiB2RX12.
PaxDbiB2RX12.
PRIDEiB2RX12.

PTM databases

PhosphoSiteiB2RX12.

Expressioni

Gene expression databases

ArrayExpressiB2RX12.
BgeeiB2RX12.
GenevestigatoriB2RX12.

Structurei

3D structure databases

ProteinModelPortaliB2RX12.
SMRiB2RX12. Positions 285-852, 972-1516.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini310 – 593284ABC transmembrane type-1 1
Add
BLAST
Domaini626 – 850225ABC transporter 1
Add
BLAST
Domaini967 – 1248282ABC transmembrane type-1 2
Add
BLAST
Domaini1287 – 1519233ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117309.
HOVERGENiHBG108314.
InParanoidiB2RX12.
KOiK05667.
OrthoDBiEOG7MWGW0.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B2RX12-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDRLCGSGEL GSKFWDSNLS IYTNTPDLTP CFQNSLLAWV PCIYLWAALP     50
CYLFYLRHHQ LGYIVLSWLS RLKTALGVLL WCVSWVDLFY SFHGLIHGSS 100
PAPVFFVTPL VVGITMLLAT LLIQYERLRG VQSSGVLIIF WLLCVICAII 150
PFRSKILSAL AEGKILDPFR FTTFYIYFAL VFCALILSCF KEKPPLFSPE 200
NLDTNPCPEA SAGFFSRLSF WWFTRLAILG YRRPLEDRDL WSLSEEDCSH 250
KVVQRLLEAW QKQQNQASGS QTATAEPKIP GEDAVLLKPR PKSKQPSFLR 300
ALVRTFTSSL LMSACFNLIQ NLLGFVNPQL LSILIRFISD PTAPTWWGFL 350
LAGLMFLSST MQTLILHQYY HCIFVMALRL RTAIIGVIYR KALVITNSVK 400
RESTVGEMVN LMSVDAQRFM DVSPFINLLW SAPLQVILAI YFLWQILGPS 450
ALAGVAVIVL LIPLNGAVSM KMKTYQVKQM KFKDSRIKLM SEILNGIKVL 500
KLYAWEPSFL EQVKGIRQSE LQLLRKGAYL QAISTFIWIC TPFLVTLITL 550
GVYVYVDESN VLDAEKAFVS LSLFNILKIP LNMLPQLISG LTQASVSLKR 600
IQDFLNQNEL DPQCVERKTI SPGYAITIHN GTFTWAQDLP PTLHSLNIQI 650
PKGALVAVVG PVGCGKSSLV SALLGEMEKL EGVVSVKGSV AYVPQQAWIQ 700
NCTLQENVLF GQPMNPKRYQ QALETCALLA DLDVLPGGDQ TEIGEKGINL 750
SGGQRQRVSL ARAVYSDANI FLLDDPLSAV DSHVAKHIFD QVIGPEGVLA 800
GKTRVLVTHG ISFLPQTDFI IVLAGGQVSE MGHYSALLQH DGSFANFLRN 850
YAPDEDQEDH EAALQNANEE VLLLEDTLST HTDLTDNEPA IYEVRKQFMR 900
EMSSLSSEGE VQNRTMPKKH TNSLEKEALV TKTKETGALI KEEIAETGNV 950
KLSVYWDYAK SMGLCTTLSI CLLYGGQSAA AIGANVWLSA WSNDAEEHGQ 1000
QNKTSVRLGV YAALGILQGL LVMLSAFTMV VGAIQAARLL HEALLHNKIR 1050
SPQSFFDTTP SGRILNRFSK DIYVIDEVLA PTILMLLNSF FTSISTIMVI 1100
VASTPLFMVV VLPLAVLYGF VQRFYVATSR QLKRLESISR SPIFSHFSET 1150
VTGTSVIRAY GRIQDFKVLS DTKVDNNQKS SYPYIASNRW LGVHVEFVGN 1200
CVVLFAALFA VIGRNSLNPG LVGLSVSYAL QVTMALNWMI RMISDLESNI 1250
IAVERVKEYS KTKTEAPWVV ESNRAPEGWP TRGMVEFRNY SVRYRPGLEL 1300
VLKNVTVHVQ GGEKVGIVGR TGAGKSSMTL CLFRILEAAE GEIVIDGLNV 1350
AHIGLHDLRS QLTIIPQDPI LFSGTLRMNL DPFGRYSEED IWRALELSHL 1400
NTFVSSQPAG LDFQCAEGGD NLSVGQRQLV CLARALLRKS RVLVLDEATA 1450
AIDLETDDLI QGTIRTQFED CTVLTIAHRL NTIMDYNRVL VLDKGVVAEF 1500
DSPVNLIAAG GIFYGMAKDA GLA 1523
Length:1,523
Mass (Da):169,124
Last modified:July 1, 2008 - v1
Checksum:iA65E6730D2C32001
GO
Isoform 2 (identifier: B2RX12-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     862-862: Missing.

Show »
Length:1,522
Mass (Da):169,053
Checksum:i1E6AAEC3E6E35D08
GO
Isoform 3 (identifier: B2RX12-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-827: Missing.

Show »
Length:1,498
Mass (Da):166,459
Checksum:i51E3AF70EA8E26E1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei803 – 82725Missing in isoform 3.
VSP_036011Add
BLAST
Alternative sequencei862 – 8621Missing in isoform 2.
VSP_036012

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811W → R in AAQ10530. 1 Publication
Sequence conflicti81 – 811W → R in AAQ10531. 1 Publication
Sequence conflicti247 – 2471D → N in BAE33375. 1 Publication
Sequence conflicti269 – 2691G → R in BAE28953. 1 Publication
Sequence conflicti269 – 2691G → R in CAI25949. 1 Publication
Sequence conflicti742 – 7421E → G in BAE33375. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY841885 mRNA. Translation: AAX39010.1.
AY795569 mRNA. Translation: AAX33774.1.
AF534127 mRNA. Translation: AAQ10530.1.
AF534128 mRNA. Translation: AAQ10531.1.
AK149551 mRNA. Translation: BAE28953.1.
AK155664 mRNA. Translation: BAE33375.1.
AL645965 Genomic DNA. Translation: CAI25949.1.
BC048825 mRNA. Translation: AAH48825.1.
BC150788 mRNA. Translation: AAI50789.1.
CCDSiCCDS25254.1. [B2RX12-2]
RefSeqiNP_083876.3. NM_029600.3.
UniGeneiMm.23942.

Genome annotation databases

EnsembliENSMUST00000021231; ENSMUSP00000021231; ENSMUSG00000020865.
GeneIDi76408.
KEGGimmu:76408.
UCSCiuc007kym.1. mouse. [B2RX12-2]
uc007kyn.1. mouse. [B2RX12-1]
uc011ycu.1. mouse. [B2RX12-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY841885 mRNA. Translation: AAX39010.1 .
AY795569 mRNA. Translation: AAX33774.1 .
AF534127 mRNA. Translation: AAQ10530.1 .
AF534128 mRNA. Translation: AAQ10531.1 .
AK149551 mRNA. Translation: BAE28953.1 .
AK155664 mRNA. Translation: BAE33375.1 .
AL645965 Genomic DNA. Translation: CAI25949.1 .
BC048825 mRNA. Translation: AAH48825.1 .
BC150788 mRNA. Translation: AAI50789.1 .
CCDSi CCDS25254.1. [B2RX12-2 ]
RefSeqi NP_083876.3. NM_029600.3.
UniGenei Mm.23942.

3D structure databases

ProteinModelPortali B2RX12.
SMRi B2RX12. Positions 285-852, 972-1516.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073683.

PTM databases

PhosphoSitei B2RX12.

Proteomic databases

MaxQBi B2RX12.
PaxDbi B2RX12.
PRIDEi B2RX12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021231 ; ENSMUSP00000021231 ; ENSMUSG00000020865 .
GeneIDi 76408.
KEGGi mmu:76408.
UCSCi uc007kym.1. mouse. [B2RX12-2 ]
uc007kyn.1. mouse. [B2RX12-1 ]
uc011ycu.1. mouse. [B2RX12-3 ]

Organism-specific databases

CTDi 8714.
MGIi MGI:1923658. Abcc3.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117309.
HOVERGENi HBG108314.
InParanoidi B2RX12.
KOi K05667.
OrthoDBi EOG7MWGW0.
TreeFami TF105199.

Miscellaneous databases

NextBioi 345093.
PROi B2RX12.
SOURCEi Search...

Gene expression databases

ArrayExpressi B2RX12.
Bgeei B2RX12.
Genevestigatori B2RX12.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. Shimizu H., Ishikawa T., Yabuuchi H.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Strain: BALB/c.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Liver.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1523 (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Brain and Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMRP3_MOUSE
AccessioniPrimary (citable) accession number: B2RX12
Secondary accession number(s): Q3U1W8
, Q56PH0, Q59DK9, Q59DL0, Q5SUF4, Q80ZK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi