Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Canalicular multispecific organic anion transporter 2

Gene

Abcc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi660 – 667ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1319 – 1326ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 2
Alternative name(s):
ATP-binding cassette sub-family C member 3
Multidrug resistance-associated protein 3
Gene namesi
Name:Abcc3
Synonyms:Cmoat2, Mrp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923658 Abcc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini57 – 75CytoplasmicSequence analysisAdd BLAST19
Transmembranei76 – 96Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini97 – 102ExtracellularSequence analysis6
Transmembranei103 – 123Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini124 – 129CytoplasmicSequence analysis6
Transmembranei130 – 150Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini151 – 170ExtracellularSequence analysisAdd BLAST20
Transmembranei171 – 191Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini192 – 301CytoplasmicSequence analysisAdd BLAST110
Transmembranei302 – 324Helical; Name=6PROSITE-ProRule annotationAdd BLAST23
Topological domaini325 – 345ExtracellularSequence analysisAdd BLAST21
Transmembranei346 – 366Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini367 – 419CytoplasmicSequence analysisAdd BLAST53
Transmembranei420 – 440Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini441ExtracellularSequence analysis1
Transmembranei442 – 462Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini463 – 535CytoplasmicSequence analysisAdd BLAST73
Transmembranei536 – 556Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini557 – 567ExtracellularSequence analysisAdd BLAST11
Transmembranei568 – 588Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini589 – 967CytoplasmicSequence analysisAdd BLAST379
Transmembranei968 – 988Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini989 – 1013ExtracellularSequence analysisAdd BLAST25
Transmembranei1014 – 1034Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1035 – 1071CytoplasmicSequence analysisAdd BLAST37
Transmembranei1072 – 1092Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1093 – 1096ExtracellularSequence analysis4
Transmembranei1097 – 1117Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1118 – 1191CytoplasmicSequence analysisAdd BLAST74
Transmembranei1192 – 1212Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1213 – 1219ExtracellularSequence analysis7
Transmembranei1220 – 1240Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1241 – 1523CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073683

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562381 – 1523Canalicular multispecific organic anion transporter 2Add BLAST1523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei903PhosphoserineBy similarity1
Modified residuei906PhosphoserineBy similarity1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiB2RX12
PaxDbiB2RX12
PeptideAtlasiB2RX12
PRIDEiB2RX12

PTM databases

iPTMnetiB2RX12
PhosphoSitePlusiB2RX12
SwissPalmiB2RX12

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021231

Structurei

3D structure databases

ProteinModelPortaliB2RX12
SMRiB2RX12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 593ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini626 – 850ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini967 – 1248ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1287 – 1519ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
HOVERGENiHBG108314
InParanoidiB2RX12
KOiK05667
TreeFamiTF105199

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RX12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRLCGSGEL GSKFWDSNLS IYTNTPDLTP CFQNSLLAWV PCIYLWAALP
60 70 80 90 100
CYLFYLRHHQ LGYIVLSWLS RLKTALGVLL WCVSWVDLFY SFHGLIHGSS
110 120 130 140 150
PAPVFFVTPL VVGITMLLAT LLIQYERLRG VQSSGVLIIF WLLCVICAII
160 170 180 190 200
PFRSKILSAL AEGKILDPFR FTTFYIYFAL VFCALILSCF KEKPPLFSPE
210 220 230 240 250
NLDTNPCPEA SAGFFSRLSF WWFTRLAILG YRRPLEDRDL WSLSEEDCSH
260 270 280 290 300
KVVQRLLEAW QKQQNQASGS QTATAEPKIP GEDAVLLKPR PKSKQPSFLR
310 320 330 340 350
ALVRTFTSSL LMSACFNLIQ NLLGFVNPQL LSILIRFISD PTAPTWWGFL
360 370 380 390 400
LAGLMFLSST MQTLILHQYY HCIFVMALRL RTAIIGVIYR KALVITNSVK
410 420 430 440 450
RESTVGEMVN LMSVDAQRFM DVSPFINLLW SAPLQVILAI YFLWQILGPS
460 470 480 490 500
ALAGVAVIVL LIPLNGAVSM KMKTYQVKQM KFKDSRIKLM SEILNGIKVL
510 520 530 540 550
KLYAWEPSFL EQVKGIRQSE LQLLRKGAYL QAISTFIWIC TPFLVTLITL
560 570 580 590 600
GVYVYVDESN VLDAEKAFVS LSLFNILKIP LNMLPQLISG LTQASVSLKR
610 620 630 640 650
IQDFLNQNEL DPQCVERKTI SPGYAITIHN GTFTWAQDLP PTLHSLNIQI
660 670 680 690 700
PKGALVAVVG PVGCGKSSLV SALLGEMEKL EGVVSVKGSV AYVPQQAWIQ
710 720 730 740 750
NCTLQENVLF GQPMNPKRYQ QALETCALLA DLDVLPGGDQ TEIGEKGINL
760 770 780 790 800
SGGQRQRVSL ARAVYSDANI FLLDDPLSAV DSHVAKHIFD QVIGPEGVLA
810 820 830 840 850
GKTRVLVTHG ISFLPQTDFI IVLAGGQVSE MGHYSALLQH DGSFANFLRN
860 870 880 890 900
YAPDEDQEDH EAALQNANEE VLLLEDTLST HTDLTDNEPA IYEVRKQFMR
910 920 930 940 950
EMSSLSSEGE VQNRTMPKKH TNSLEKEALV TKTKETGALI KEEIAETGNV
960 970 980 990 1000
KLSVYWDYAK SMGLCTTLSI CLLYGGQSAA AIGANVWLSA WSNDAEEHGQ
1010 1020 1030 1040 1050
QNKTSVRLGV YAALGILQGL LVMLSAFTMV VGAIQAARLL HEALLHNKIR
1060 1070 1080 1090 1100
SPQSFFDTTP SGRILNRFSK DIYVIDEVLA PTILMLLNSF FTSISTIMVI
1110 1120 1130 1140 1150
VASTPLFMVV VLPLAVLYGF VQRFYVATSR QLKRLESISR SPIFSHFSET
1160 1170 1180 1190 1200
VTGTSVIRAY GRIQDFKVLS DTKVDNNQKS SYPYIASNRW LGVHVEFVGN
1210 1220 1230 1240 1250
CVVLFAALFA VIGRNSLNPG LVGLSVSYAL QVTMALNWMI RMISDLESNI
1260 1270 1280 1290 1300
IAVERVKEYS KTKTEAPWVV ESNRAPEGWP TRGMVEFRNY SVRYRPGLEL
1310 1320 1330 1340 1350
VLKNVTVHVQ GGEKVGIVGR TGAGKSSMTL CLFRILEAAE GEIVIDGLNV
1360 1370 1380 1390 1400
AHIGLHDLRS QLTIIPQDPI LFSGTLRMNL DPFGRYSEED IWRALELSHL
1410 1420 1430 1440 1450
NTFVSSQPAG LDFQCAEGGD NLSVGQRQLV CLARALLRKS RVLVLDEATA
1460 1470 1480 1490 1500
AIDLETDDLI QGTIRTQFED CTVLTIAHRL NTIMDYNRVL VLDKGVVAEF
1510 1520
DSPVNLIAAG GIFYGMAKDA GLA
Length:1,523
Mass (Da):169,124
Last modified:July 1, 2008 - v1
Checksum:iA65E6730D2C32001
GO
Isoform 2 (identifier: B2RX12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     862-862: Missing.

Show »
Length:1,522
Mass (Da):169,053
Checksum:i1E6AAEC3E6E35D08
GO
Isoform 3 (identifier: B2RX12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-827: Missing.

Show »
Length:1,498
Mass (Da):166,459
Checksum:i51E3AF70EA8E26E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81W → R in AAQ10530 (Ref. 2) Curated1
Sequence conflicti81W → R in AAQ10531 (Ref. 2) Curated1
Sequence conflicti247D → N in BAE33375 (PubMed:16141072).Curated1
Sequence conflicti269G → R in BAE28953 (PubMed:16141072).Curated1
Sequence conflicti269G → R in CAI25949 (PubMed:19468303).Curated1
Sequence conflicti742E → G in BAE33375 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036011803 – 827Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_036012862Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY841885 mRNA Translation: AAX39010.1
AY795569 mRNA Translation: AAX33774.1
AF534127 mRNA Translation: AAQ10530.1
AF534128 mRNA Translation: AAQ10531.1
AK149551 mRNA Translation: BAE28953.1
AK155664 mRNA Translation: BAE33375.1
AL645965 Genomic DNA Translation: CAI25949.1
BC048825 mRNA Translation: AAH48825.1
BC150788 mRNA Translation: AAI50789.1
CCDSiCCDS25254.1 [B2RX12-2]
RefSeqiNP_083876.3, NM_029600.3
UniGeneiMm.23942

Genome annotation databases

GeneIDi76408
KEGGimmu:76408
UCSCiuc007kym.1 mouse [B2RX12-2]
uc011ycu.1 mouse [B2RX12-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMRP3_MOUSE
AccessioniPrimary (citable) accession number: B2RX12
Secondary accession number(s): Q3U1W8
, Q56PH0, Q59DK9, Q59DL0, Q5SUF4, Q80ZK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 1, 2008
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health