Gm5741

Functionⁱ

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.UniRule annotation

GO - Molecular functionⁱ

signal transducer activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	TransducerUniRule annotationSAAS annotation

Molecular function

TransducerUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanine nucleotide-binding protein subunit gammaUniRule annotation
Gene namesⁱ	Name:Gm5741Imported Synonyms:EG436049Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:3645690. Gm5741.

Subcellular locationⁱ

Cell membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU004973
; Lipid-anchor
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU004973
; Cytoplasmic side
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU004973

GO - Cellular componentⁱ

heterotrimeric G-protein complex Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membraneUniRule annotation, Membrane

PTM / Processingⁱ

Keywords - PTMⁱ

LipoproteinUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000095845.

Bgeeⁱ

ENSMUSG00000095845.

Interactionⁱ

Subunit structureⁱ

G proteins are composed of 3 units, alpha, beta and gamma.SAAS annotation

G proteins are composed of 3 units; alpha, beta and gamma.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000136655.

STRINGⁱ

10090.ENSMUSP00000136655.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 72	G protein gammaInterPro annotationAdd BLAST		66

Sequence similaritiesⁱ

Belongs to the G protein gamma family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG4119. Eukaryota. ENOG41122JF. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119218.
HOVERGENⁱ	HBG014983.
KEGG Orthology (KO) More...KOⁱ	K04347.
OMAⁱ	LLQFCME.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17J0.
TreeFamⁱ	TF319909.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068. GGL. 1 hit.
InterProⁱ	View protein in InterPro IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma.
PANTHERⁱ	PTHR13809. PTHR13809. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00631. G-gamma. 1 hit.
PRINTSⁱ	PR00321. GPROTEING.
SMARTⁱ	View protein in SMART SM00224. GGL. 1 hit.
SUPFAMⁱ	SSF48670. SSF48670. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B2RVA4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSKVATGSD IGQARRAVEQ LRMEAGINRI KVSKAATDLL QFCTEQAKSD 
        60         70 
PFLVGIPAAT NPFKEKKPCA IL

Length:72

Mass (Da):7,748

Last modified:July 1, 2008 - v1

Checksum:ⁱ78AB51B3D3A4394F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC163703 Genomic DNA. No translation available. BC147108 mRNA. Translation: AAI47109.1. BC147109 mRNA. Translation: AAI47110.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001182460.1. NM_001195531.1.
UniGeneⁱ	Mm.440240.

Genome annotation databases

Ensemblⁱ	ENSMUST00000177563; ENSMUSP00000136655; ENSMUSG00000095845.
GeneIDⁱ	100503710.
KEGGⁱ	mmu:100503710.
UCSC genome browser More...UCSCⁱ	uc012ghp.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC163703 Genomic DNA. No translation available. BC147108 mRNA. Translation: AAI47109.1. BC147109 mRNA. Translation: AAI47110.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001182460.1. NM_001195531.1.
UniGeneⁱ	Mm.440240.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000136655.

STRINGⁱ

10090.ENSMUSP00000136655.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000177563; ENSMUSP00000136655; ENSMUSG00000095845.
GeneIDⁱ	100503710.
KEGGⁱ	mmu:100503710.
UCSC genome browser More...UCSCⁱ	uc012ghp.1. mouse.

Organism-specific databases

MGIⁱ	MGI:3645690. Gm5741.

Phylogenomic databases

eggNOGⁱ	KOG4119. Eukaryota. ENOG41122JF. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119218.
HOVERGENⁱ	HBG014983.
KEGG Orthology (KO) More...KOⁱ	K04347.
OMAⁱ	LLQFCME.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G17J0.
TreeFamⁱ	TF319909.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000095845.

Bgeeⁱ

ENSMUSG00000095845.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00068. GGL. 1 hit.
InterProⁱ	View protein in InterPro IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma.
PANTHERⁱ	PTHR13809. PTHR13809. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00631. G-gamma. 1 hit.
PRINTSⁱ	PR00321. GPROTEING.
SMARTⁱ	View protein in SMART SM00224. GGL. 1 hit.
SUPFAMⁱ	SSF48670. SSF48670. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50058. G_PROTEIN_GAMMA. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2RVA4_MOUSE
Accessionⁱ	B2RVA4Primary (citable) accession number: B2RVA4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 1, 2008
	Last sequence update:	July 1, 2008
	Last modified:	June 7, 2017
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2RVA4 (B2RVA4_MOUSE)

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Guanine nucleotide-binding protein subunit gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ