ID   CF97D_HUMAN             Reviewed;         164 AA.
AC   B2RV13;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   24-JAN-2024, entry version 95.
DE   RecName: Full=Sperm axonemal maintenance protein CFAP97D1 {ECO:0000305};
DE   AltName: Full=CFAP97 domain-containing protein 1;
GN   Name=CFAP97D1 {ECO:0000312|HGNC:HGNC:37241}; Synonyms=C17orf105;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=32785227; DOI=10.1371/journal.pgen.1008954;
RA   Oura S., Kazi S., Savolainen A., Nozawa K., Castaneda J., Yu Z., Miyata H.,
RA   Matzuk R.M., Hansen J.N., Wachten D., Matzuk M.M.,
RA   Prunskaite-Hyyrylaeinen R.;
RT   "Cfap97d1 is important for flagellar axoneme maintenance and male mouse
RT   fertility.";
RL   PLoS Genet. 16:e1008954-e1008954(2020).
CC   -!- FUNCTION: Required for male fertility through its role in axonemal
CC       doublet stabilization which is essential for sperm motility and
CC       fertilization. {ECO:0000250|UniProtKB:Q9DAN9}.
CC   -!- INTERACTION:
CC       B2RV13; P41182: BCL6; NbExp=3; IntAct=EBI-12870048, EBI-765407;
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC       {ECO:0000269|PubMed:32785227}.
CC   -!- SIMILARITY: Belongs to the CFAP97 family. {ECO:0000305}.
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DR   EMBL; AC003098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC146971; AAI46972.1; -; mRNA.
DR   CCDS; CCDS45695.1; -.
DR   RefSeq; NP_001129955.1; NM_001136483.1.
DR   RefSeq; XP_011522935.1; XM_011524633.1.
DR   AlphaFoldDB; B2RV13; -.
DR   SMR; B2RV13; -.
DR   BioGRID; 129747; 8.
DR   IntAct; B2RV13; 6.
DR   STRING; 9606.ENSP00000415662; -.
DR   iPTMnet; B2RV13; -.
DR   PhosphoSitePlus; B2RV13; -.
DR   BioMuta; C17orf105; -.
DR   jPOST; B2RV13; -.
DR   MassIVE; B2RV13; -.
DR   PaxDb; 9606-ENSP00000415662; -.
DR   PeptideAtlas; B2RV13; -.
DR   ProteomicsDB; 3459; -.
DR   Antibodypedia; 29596; 15 antibodies from 10 providers.
DR   DNASU; 284067; -.
DR   Ensembl; ENST00000449302.8; ENSP00000415662.2; ENSG00000231256.8.
DR   GeneID; 284067; -.
DR   KEGG; hsa:284067; -.
DR   MANE-Select; ENST00000449302.8; ENSP00000415662.2; NM_001136483.3; NP_001129955.1.
DR   UCSC; uc002ieg.4; human.
DR   AGR; HGNC:37241; -.
DR   CTD; 284067; -.
DR   GeneCards; CFAP97D1; -.
DR   HGNC; HGNC:37241; CFAP97D1.
DR   HPA; ENSG00000231256; Tissue enriched (testis).
DR   MIM; 619866; gene.
DR   neXtProt; NX_B2RV13; -.
DR   OpenTargets; ENSG00000231256; -.
DR   PharmGKB; PA165431514; -.
DR   VEuPathDB; HostDB:ENSG00000231256; -.
DR   eggNOG; ENOG502S44E; Eukaryota.
DR   GeneTree; ENSGT00390000018148; -.
DR   HOGENOM; CLU_097298_2_0_1; -.
DR   InParanoid; B2RV13; -.
DR   OMA; DHVQWEE; -.
DR   OrthoDB; 3900836at2759; -.
DR   PhylomeDB; B2RV13; -.
DR   TreeFam; TF325279; -.
DR   PathwayCommons; B2RV13; -.
DR   SignaLink; B2RV13; -.
DR   BioGRID-ORCS; 284067; 21 hits in 1111 CRISPR screens.
DR   GenomeRNAi; 284067; -.
DR   Pharos; B2RV13; Tdark.
DR   PRO; PR:B2RV13; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; B2RV13; Protein.
DR   Bgee; ENSG00000231256; Expressed in sperm and 41 other cell types or tissues.
DR   ExpressionAtlas; B2RV13; baseline and differential.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   InterPro; IPR038792; CFAP97D1/2.
DR   InterPro; IPR029488; Hmw/CFAP97.
DR   PANTHER; PTHR33768; MIP11318P; 1.
DR   PANTHER; PTHR33768:SF5; SPERM AXONEMAL MAINTENANCE PROTEIN CFAP97D1; 1.
DR   Pfam; PF13879; Hmw_CFAP97; 1.
DR   Genevisible; B2RV13; HS.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..164
FT                   /note="Sperm axonemal maintenance protein CFAP97D1"
FT                   /id="PRO_0000392549"
FT   COILED          61..90
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  19546 MW;  A8C00E583BE704F2 CRC64;
     MNNSLDYLAY PVIVSNHRQS TTFRKKLDFG HYVSHKNRIQ IAKPTVDTKP PVAHTNHILK
     LSKLQGEQKK INKIEYENKQ LCQKIANAHR GPAKVDCWNE YFSKSLNRET RNRELVRITM
     ENQGILKRLV DRKPHYDRRA SEIDWQNSRR YIRNTTRYLL SQNE
//