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B2RUY7 (VWC2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
von Willebrand factor C domain-containing protein 2-like
Alternative name(s):
Brorin-like
Gene names
Name:VWC2L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in neurogenesis By similarity. May play a role in bone differentiation and matrix mineralization By similarity.

Subunit structure

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.

Subcellular location

Secreted By similarity. Cell junctionsynapse By similarity.

Sequence similarities

Contains 2 VWFC domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B2RUY7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B2RUY7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     131-138: PSPCEWCR → VCVTLHIY
     139-222: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 222201von Willebrand factor C domain-containing protein 2-like
PRO_0000348060

Regions

Domain51 – 11060VWFC 1
Domain114 – 17259VWFC 2

Natural variations

Alternative sequence131 – 1388PSPCEWCR → VCVTLHIY in isoform 2.
VSP_035088
Alternative sequence139 – 22284Missing in isoform 2.
VSP_035089

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 7047CE3CBA835B54

FASTA22224,570
        10         20         30         40         50         60 
MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG KGCVDDSGFV 

        70         80         90        100        110        120 
YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYHG 

       130        140        150        160        170        180 
KNYKILEEFK PSPCEWCRCE PSNEVHCVVA DCAVPECVNP VYEPEQCCPV CKNGPNCFAG 

       190        200        210        220 
TTIIPAGIEV KVDECNICHC HNGDWWKPAQ CSKRECQGKQ TV 

« Hide

Isoform 2 [UniParc].

Checksum: A6E25B068821A555
Show »

FASTA13815,394

References

« Hide 'large scale' references
[1]"A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A novel cysteine-knot protein regulates matrix mineralization."
Mochida Y., Yamauchi M.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB374231 mRNA. Translation: BAH04176.1.
EU541473 mRNA. Translation: ACD62527.1.
AC107218 Genomic DNA. No translation available.
BC146903 mRNA. Translation: AAI46904.1.
BC146911 mRNA. Translation: AAI46912.1.
BC146931 mRNA. Translation: AAI46932.1.
BC146935 mRNA. Translation: AAI46936.1.
CCDSCCDS46509.1. [B2RUY7-1]
RefSeqNP_001073969.1. NM_001080500.2. [B2RUY7-1]
UniGeneHs.534834.

3D structure databases

ProteinModelPortalB2RUY7.
SMRB2RUY7. Positions 50-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308976.

Proteomic databases

PaxDbB2RUY7.
PRIDEB2RUY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312504; ENSP00000308976; ENSG00000174453. [B2RUY7-1]
GeneID402117.
KEGGhsa:402117.
UCSCuc002vet.2. human. [B2RUY7-1]

Organism-specific databases

CTD402117.
GeneCardsGC02P215275.
HGNCHGNC:37203. VWC2L.
HPAHPA044815.
HPA059414.
neXtProtNX_B2RUY7.
PharmGKBPA165697841.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83498.
HOGENOMHOG000036086.
HOVERGENHBG068398.
InParanoidB2RUY7.
OMAFRITDIY.
OrthoDBEOG73Z2TT.
PhylomeDBB2RUY7.
TreeFamTF329913.

Gene expression databases

BgeeB2RUY7.
GenevestigatorB2RUY7.

Family and domain databases

InterProIPR001007. VWF_C.
[Graphical view]
SMARTSM00214. VWC. 1 hit.
[Graphical view]
PROSITEPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi402117.
NextBio107306.
PROB2RUY7.

Entry information

Entry nameVWC2L_HUMAN
AccessionPrimary (citable) accession number: B2RUY7
Secondary accession number(s): A6NC69, B2RUW7, B7X8X1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM