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Protein

von Willebrand factor C domain-containing protein 2-like

Gene

VWC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C domain-containing protein 2-like
Alternative name(s):
Brorin-like
Gene namesi
Name:VWC2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:37203. VWC2L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi402117.
OpenTargetsiENSG00000174453.
PharmGKBiPA165697841.

Polymorphism and mutation databases

BioMutaiVWC2L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000034806022 – 222von Willebrand factor C domain-containing protein 2-likeAdd BLAST201

Proteomic databases

PaxDbiB2RUY7.
PRIDEiB2RUY7.

PTM databases

iPTMnetiB2RUY7.
PhosphoSitePlusiB2RUY7.

Expressioni

Gene expression databases

BgeeiENSG00000174453.
ExpressionAtlasiB2RUY7. baseline and differential.

Organism-specific databases

HPAiHPA044815.
HPA059414.

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136434EBI-11747707,EBI-741101
OTX1P322424EBI-11747707,EBI-740446

Protein-protein interaction databases

IntActiB2RUY7. 4 interactors.
STRINGi9606.ENSP00000308976.

Structurei

3D structure databases

ProteinModelPortaliB2RUY7.
SMRiB2RUY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 110VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini114 – 172VWFC 2PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHPX. Eukaryota.
ENOG410XTA9. LUCA.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB2RUY7.
OMAiCLRRECL.
OrthoDBiEOG091G0Q3M.
PhylomeDBiB2RUY7.
TreeFamiTF329913.

Family and domain databases

InterProiIPR001007. VWF_dom.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RUY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG
60 70 80 90 100
KGCVDDSGFV YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV
110 120 130 140 150
EHNGCCPECK EVKNFCEYHG KNYKILEEFK PSPCEWCRCE PSNEVHCVVA
160 170 180 190 200
DCAVPECVNP VYEPEQCCPV CKNGPNCFAG TTIIPAGIEV KVDECNICHC
210 220
HNGDWWKPAQ CSKRECQGKQ TV
Length:222
Mass (Da):24,570
Last modified:September 2, 2008 - v1
Checksum:i7047CE3CBA835B54
GO
Isoform 2 (identifier: B2RUY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-138: PSPCEWCR → VCVTLHIY
     139-222: Missing.

Show »
Length:138
Mass (Da):15,394
Checksum:iA6E25B068821A555
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035088131 – 138PSPCEWCR → VCVTLHIY in isoform 2. Curated8
Alternative sequenceiVSP_035089139 – 222Missing in isoform 2. CuratedAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374231 mRNA. Translation: BAH04176.1.
EU541473 mRNA. Translation: ACD62527.1.
AC107218 Genomic DNA. No translation available.
BC146903 mRNA. Translation: AAI46904.1.
BC146911 mRNA. Translation: AAI46912.1.
BC146931 mRNA. Translation: AAI46932.1.
BC146935 mRNA. Translation: AAI46936.1.
CCDSiCCDS46509.1. [B2RUY7-1]
RefSeqiNP_001073969.1. NM_001080500.3. [B2RUY7-1]
UniGeneiHs.534834.

Genome annotation databases

EnsembliENST00000312504; ENSP00000308976; ENSG00000174453. [B2RUY7-1]
GeneIDi402117.
KEGGihsa:402117.
UCSCiuc002vet.3. human. [B2RUY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374231 mRNA. Translation: BAH04176.1.
EU541473 mRNA. Translation: ACD62527.1.
AC107218 Genomic DNA. No translation available.
BC146903 mRNA. Translation: AAI46904.1.
BC146911 mRNA. Translation: AAI46912.1.
BC146931 mRNA. Translation: AAI46932.1.
BC146935 mRNA. Translation: AAI46936.1.
CCDSiCCDS46509.1. [B2RUY7-1]
RefSeqiNP_001073969.1. NM_001080500.3. [B2RUY7-1]
UniGeneiHs.534834.

3D structure databases

ProteinModelPortaliB2RUY7.
SMRiB2RUY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB2RUY7. 4 interactors.
STRINGi9606.ENSP00000308976.

PTM databases

iPTMnetiB2RUY7.
PhosphoSitePlusiB2RUY7.

Polymorphism and mutation databases

BioMutaiVWC2L.

Proteomic databases

PaxDbiB2RUY7.
PRIDEiB2RUY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312504; ENSP00000308976; ENSG00000174453. [B2RUY7-1]
GeneIDi402117.
KEGGihsa:402117.
UCSCiuc002vet.3. human. [B2RUY7-1]

Organism-specific databases

CTDi402117.
DisGeNETi402117.
GeneCardsiVWC2L.
HGNCiHGNC:37203. VWC2L.
HPAiHPA044815.
HPA059414.
neXtProtiNX_B2RUY7.
OpenTargetsiENSG00000174453.
PharmGKBiPA165697841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHPX. Eukaryota.
ENOG410XTA9. LUCA.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB2RUY7.
OMAiCLRRECL.
OrthoDBiEOG091G0Q3M.
PhylomeDBiB2RUY7.
TreeFamiTF329913.

Miscellaneous databases

GenomeRNAii402117.
PROiB2RUY7.

Gene expression databases

BgeeiENSG00000174453.
ExpressionAtlasiB2RUY7. baseline and differential.

Family and domain databases

InterProiIPR001007. VWF_dom.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVWC2L_HUMAN
AccessioniPrimary (citable) accession number: B2RUY7
Secondary accession number(s): A6NC69, B2RUW7, B7X8X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.