B2RUY7 (VWC2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
von Willebrand factor C domain-containing protein 2-like

Alternative name(s):
Brorin-like

Gene names

Name:

VWC2L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in neurogenesis By similarity. May play a role in bone differentiation and matrix mineralization By similarity.
Subunit structure	Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.
Subcellular location	Secreted By similarity. Cell junction › synapse By similarity.
Sequence similarities	Contains 2 VWFC domains.

Ontologies

Keywords
Cellular component	Cell junction Secreted Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: Compara synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B2RUY7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B2RUY7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     131-138: PSPCEWCR → VCVTLHIY
     139-222: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 222	201	von Willebrand factor C domain-containing protein 2-like		PRO_0000348060
Regions
	Domain	51 – 110	60	VWFC 1
	Domain	114 – 172	59	VWFC 2
Natural variations
	Alternative sequence	131 – 138	8	PSPCEWCR → VCVTLHIY in isoform 2.		VSP_035088
	Alternative sequence	139 – 222	84	Missing in isoform 2.		VSP_035089

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 2, 2008. Version 1. Checksum: 7047CE3CBA835B54	FASTA	222	24,570
	10 20 30 40 50 60 MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG KGCVDDSGFV 70 80 90 100 110 120 YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYHG 130 140 150 160 170 180 KNYKILEEFK PSPCEWCRCE PSNEVHCVVA DCAVPECVNP VYEPEQCCPV CKNGPNCFAG 190 200 210 220 TTIIPAGIEV KVDECNICHC HNGDWWKPAQ CSKRECQGKQ TV
	Isoform 2 [UniParc]. Checksum: A6E25B068821A555	FASTA	138	15,394
	10 20 30 40 50 60 MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG KGCVDDSGFV 70 80 90 100 110 120 YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV EHNGCCPECK EVKNFCEYHG 130 KNYKILEEFK VCVTLHIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family." Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N. FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"A novel cysteine-knot protein regulates matrix mineralization." Mochida Y., Yamauchi M. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB374231 mRNA. Translation: BAH04176.1. EU541473 mRNA. Translation: ACD62527.1. AC107218 Genomic DNA. No translation available. BC146903 mRNA. Translation: AAI46904.1. BC146911 mRNA. Translation: AAI46912.1. BC146931 mRNA. Translation: AAI46932.1. BC146935 mRNA. Translation: AAI46936.1.
IPI	IPI00402291. IPI00941625.
RefSeq	NP_001073969.1. NM_001080500.2.
UniGene	Hs.534834.
3D structure databases
ProteinModelPortal	B2RUY7.
SMR	B2RUY7. Positions 50-173.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308976.
Proteomic databases
PaxDb	B2RUY7.
PRIDE	B2RUY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312504; ENSP00000308976; ENSG00000174453.
GeneID	402117.
KEGG	hsa:402117.
UCSC	uc002vet.2. human.
Organism-specific databases
CTD	402117.
GeneCards	GC02P215275.
HGNC	HGNC:37203. VWC2L.
HPA	HPA044815.
neXtProt	NX_B2RUY7.
PharmGKB	PA165697841.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83498.
HOGENOM	HOG000036086.
HOVERGEN	HBG068398.
InParanoid	B2RUY7.
OMA	CLRRECL.
OrthoDB	EOG40ZQZV.
Gene expression databases
ArrayExpress	B2RUY7.
Bgee	B2RUY7.
Genevestigator	B2RUY7.
Family and domain databases
InterPro	IPR001007. VWF_C. [Graphical view]
SMART	SM00214. VWC. 1 hit. [Graphical view]
PROSITE	PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	402117.
NextBio	107306.

Entry information

Entry name

VWC2L_HUMAN

Accession

Primary (citable) accession number: B2RUY7
Secondary accession number(s): A6NC69, B2RUW7, B7X8X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	September 2, 2008
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.