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Protein

von Willebrand factor C domain-containing protein 2-like

Gene

VWC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.By similarity

GO - Biological processi

  1. negative regulation of BMP signaling pathway Source: Ensembl
  2. positive regulation of neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C domain-containing protein 2-like
Alternative name(s):
Brorin-like
Gene namesi
Name:VWC2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:37203. VWC2L.

Subcellular locationi

Secreted By similarity. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. extracellular space Source: Ensembl
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165697841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 222201von Willebrand factor C domain-containing protein 2-likePRO_0000348060Add
BLAST

Proteomic databases

PaxDbiB2RUY7.
PRIDEiB2RUY7.

Expressioni

Gene expression databases

BgeeiB2RUY7.
ExpressionAtlasiB2RUY7. baseline.
GenevestigatoriB2RUY7.

Organism-specific databases

HPAiHPA044815.
HPA059414.

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000308976.

Structurei

3D structure databases

ProteinModelPortaliB2RUY7.
SMRiB2RUY7. Positions 52-153, 164-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 11060VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 17259VWFC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB2RUY7.
OMAiCLRRECL.
OrthoDBiEOG73Z2TT.
PhylomeDBiB2RUY7.
TreeFamiTF329913.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B2RUY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG
60 70 80 90 100
KGCVDDSGFV YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV
110 120 130 140 150
EHNGCCPECK EVKNFCEYHG KNYKILEEFK PSPCEWCRCE PSNEVHCVVA
160 170 180 190 200
DCAVPECVNP VYEPEQCCPV CKNGPNCFAG TTIIPAGIEV KVDECNICHC
210 220
HNGDWWKPAQ CSKRECQGKQ TV
Length:222
Mass (Da):24,570
Last modified:September 2, 2008 - v1
Checksum:i7047CE3CBA835B54
GO
Isoform 2 (identifier: B2RUY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-138: PSPCEWCR → VCVTLHIY
     139-222: Missing.

Show »
Length:138
Mass (Da):15,394
Checksum:iA6E25B068821A555
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei131 – 1388PSPCEWCR → VCVTLHIY in isoform 2. CuratedVSP_035088
Alternative sequencei139 – 22284Missing in isoform 2. CuratedVSP_035089Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374231 mRNA. Translation: BAH04176.1.
EU541473 mRNA. Translation: ACD62527.1.
AC107218 Genomic DNA. No translation available.
BC146903 mRNA. Translation: AAI46904.1.
BC146911 mRNA. Translation: AAI46912.1.
BC146931 mRNA. Translation: AAI46932.1.
BC146935 mRNA. Translation: AAI46936.1.
CCDSiCCDS46509.1. [B2RUY7-1]
RefSeqiNP_001073969.1. NM_001080500.2. [B2RUY7-1]
UniGeneiHs.534834.

Genome annotation databases

EnsembliENST00000312504; ENSP00000308976; ENSG00000174453. [B2RUY7-1]
GeneIDi402117.
KEGGihsa:402117.
UCSCiuc002vet.2. human. [B2RUY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374231 mRNA. Translation: BAH04176.1.
EU541473 mRNA. Translation: ACD62527.1.
AC107218 Genomic DNA. No translation available.
BC146903 mRNA. Translation: AAI46904.1.
BC146911 mRNA. Translation: AAI46912.1.
BC146931 mRNA. Translation: AAI46932.1.
BC146935 mRNA. Translation: AAI46936.1.
CCDSiCCDS46509.1. [B2RUY7-1]
RefSeqiNP_001073969.1. NM_001080500.2. [B2RUY7-1]
UniGeneiHs.534834.

3D structure databases

ProteinModelPortaliB2RUY7.
SMRiB2RUY7. Positions 52-153, 164-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308976.

Proteomic databases

PaxDbiB2RUY7.
PRIDEiB2RUY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312504; ENSP00000308976; ENSG00000174453. [B2RUY7-1]
GeneIDi402117.
KEGGihsa:402117.
UCSCiuc002vet.2. human. [B2RUY7-1]

Organism-specific databases

CTDi402117.
GeneCardsiGC02P215275.
HGNCiHGNC:37203. VWC2L.
HPAiHPA044815.
HPA059414.
neXtProtiNX_B2RUY7.
PharmGKBiPA165697841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG068398.
InParanoidiB2RUY7.
OMAiCLRRECL.
OrthoDBiEOG73Z2TT.
PhylomeDBiB2RUY7.
TreeFamiTF329913.

Miscellaneous databases

GenomeRNAii402117.
NextBioi107306.
PROiB2RUY7.

Gene expression databases

BgeeiB2RUY7.
ExpressionAtlasiB2RUY7. baseline.
GenevestigatoriB2RUY7.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
    Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
    FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel cysteine-knot protein regulates matrix mineralization."
    Mochida Y., Yamauchi M.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain cortex.

Entry informationi

Entry nameiVWC2L_HUMAN
AccessioniPrimary (citable) accession number: B2RUY7
Secondary accession number(s): A6NC69, B2RUW7, B7X8X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.