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B2RUY7

- VWC2L_HUMAN

UniProt

B2RUY7 - VWC2L_HUMAN

Protein

von Willebrand factor C domain-containing protein 2-like

Gene

VWC2L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.By similarity

    GO - Biological processi

    1. negative regulation of BMP signaling pathway Source: Ensembl
    2. positive regulation of neuron differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    von Willebrand factor C domain-containing protein 2-like
    Alternative name(s):
    Brorin-like
    Gene namesi
    Name:VWC2L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:37203. VWC2L.

    Subcellular locationi

    Secreted By similarity. Cell junctionsynapse By similarity

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. extracellular space Source: Ensembl
    4. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Secreted, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165697841.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 222201von Willebrand factor C domain-containing protein 2-likePRO_0000348060Add
    BLAST

    Proteomic databases

    PaxDbiB2RUY7.
    PRIDEiB2RUY7.

    Expressioni

    Gene expression databases

    BgeeiB2RUY7.
    GenevestigatoriB2RUY7.

    Organism-specific databases

    HPAiHPA044815.
    HPA059414.

    Interactioni

    Subunit structurei

    Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308976.

    Structurei

    3D structure databases

    ProteinModelPortaliB2RUY7.
    SMRiB2RUY7. Positions 50-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 11060VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini114 – 17259VWFC 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG83498.
    HOGENOMiHOG000036086.
    HOVERGENiHBG068398.
    InParanoidiB2RUY7.
    OMAiFRITDIY.
    OrthoDBiEOG73Z2TT.
    PhylomeDBiB2RUY7.
    TreeFamiTF329913.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    SMARTiSM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B2RUY7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG    50
    KGCVDDSGFV YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV 100
    EHNGCCPECK EVKNFCEYHG KNYKILEEFK PSPCEWCRCE PSNEVHCVVA 150
    DCAVPECVNP VYEPEQCCPV CKNGPNCFAG TTIIPAGIEV KVDECNICHC 200
    HNGDWWKPAQ CSKRECQGKQ TV 222
    Length:222
    Mass (Da):24,570
    Last modified:September 2, 2008 - v1
    Checksum:i7047CE3CBA835B54
    GO
    Isoform 2 (identifier: B2RUY7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         131-138: PSPCEWCR → VCVTLHIY
         139-222: Missing.

    Show »
    Length:138
    Mass (Da):15,394
    Checksum:iA6E25B068821A555
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei131 – 1388PSPCEWCR → VCVTLHIY in isoform 2. CuratedVSP_035088
    Alternative sequencei139 – 22284Missing in isoform 2. CuratedVSP_035089Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB374231 mRNA. Translation: BAH04176.1.
    EU541473 mRNA. Translation: ACD62527.1.
    AC107218 Genomic DNA. No translation available.
    BC146903 mRNA. Translation: AAI46904.1.
    BC146911 mRNA. Translation: AAI46912.1.
    BC146931 mRNA. Translation: AAI46932.1.
    BC146935 mRNA. Translation: AAI46936.1.
    CCDSiCCDS46509.1. [B2RUY7-1]
    RefSeqiNP_001073969.1. NM_001080500.2. [B2RUY7-1]
    UniGeneiHs.534834.

    Genome annotation databases

    EnsembliENST00000312504; ENSP00000308976; ENSG00000174453. [B2RUY7-1]
    GeneIDi402117.
    KEGGihsa:402117.
    UCSCiuc002vet.2. human. [B2RUY7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB374231 mRNA. Translation: BAH04176.1 .
    EU541473 mRNA. Translation: ACD62527.1 .
    AC107218 Genomic DNA. No translation available.
    BC146903 mRNA. Translation: AAI46904.1 .
    BC146911 mRNA. Translation: AAI46912.1 .
    BC146931 mRNA. Translation: AAI46932.1 .
    BC146935 mRNA. Translation: AAI46936.1 .
    CCDSi CCDS46509.1. [B2RUY7-1 ]
    RefSeqi NP_001073969.1. NM_001080500.2. [B2RUY7-1 ]
    UniGenei Hs.534834.

    3D structure databases

    ProteinModelPortali B2RUY7.
    SMRi B2RUY7. Positions 50-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308976.

    Proteomic databases

    PaxDbi B2RUY7.
    PRIDEi B2RUY7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312504 ; ENSP00000308976 ; ENSG00000174453 . [B2RUY7-1 ]
    GeneIDi 402117.
    KEGGi hsa:402117.
    UCSCi uc002vet.2. human. [B2RUY7-1 ]

    Organism-specific databases

    CTDi 402117.
    GeneCardsi GC02P215275.
    HGNCi HGNC:37203. VWC2L.
    HPAi HPA044815.
    HPA059414.
    neXtProti NX_B2RUY7.
    PharmGKBi PA165697841.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83498.
    HOGENOMi HOG000036086.
    HOVERGENi HBG068398.
    InParanoidi B2RUY7.
    OMAi FRITDIY.
    OrthoDBi EOG73Z2TT.
    PhylomeDBi B2RUY7.
    TreeFami TF329913.

    Miscellaneous databases

    GenomeRNAii 402117.
    NextBioi 107306.
    PROi B2RUY7.

    Gene expression databases

    Bgeei B2RUY7.
    Genevestigatori B2RUY7.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    SMARTi SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family."
      Miwa H., Miyake A., Kouta Y., Shimada A., Yamashita Y., Nakayama Y., Yamauchi H., Konishi M., Itoh N.
      FEBS Lett. 583:3643-3648(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "A novel cysteine-knot protein regulates matrix mineralization."
      Mochida Y., Yamauchi M.
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiVWC2L_HUMAN
    AccessioniPrimary (citable) accession number: B2RUY7
    Secondary accession number(s): A6NC69, B2RUW7, B7X8X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3