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B2RUS7

- B2RUS7_MOUSE

UniProt

B2RUS7 - B2RUS7_MOUSE

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Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Gene
Abcc8
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. sulfonylurea receptor activity Source: InterPro

GO - Biological processi

  1. potassium ion transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199102. ATP sensitive Potassium channels.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 8Imported
Submitted name:
Protein Abcc8Imported
Gene namesi
Name:Abcc8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352629. Abcc8.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: MGI
  2. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB2RUS7.

Interactioni

Protein-protein interaction databases

DIPiDIP-58644N.

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation
Contains ABC transmembrane type-1 domains.SAAS annotations
Contains ABC transmembrane type-domains.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117379.
HOVERGENiHBG101342.
InParanoidiB2RUS7.
KOiK05032.
OMAiRKDSVFA.
OrthoDBiEOG7MWGW0.
TreeFamiTF105201.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
IPR000844. Surea_rcpt-1.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RUS7-1 [UniParc]FASTAAdd to Basket

« Hide

MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG     50
WGSQSSKVHI HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE 100
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 150
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEINVI RVRRYIFFKT 200
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HRKPIDLRAI 250
GKLPIAMRAL TNYQRLCAAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 300
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 350
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 400
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 450
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 500
EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT SISIFMNTAI 550
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 600
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 650
PAREEVRDLL GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 700
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QRVSGAVFWN SSLPDSEGED 750
PRYCLRTSNP ERETAADSDA RSRGPVAYAS QKPWLLNATV EENITFESPF 800
NKQRYKMVIE ACSLQPDIDI LPHGDQTQIG ERGINLSGGQ RQRISVARAL 850
YQHTNVVFLD DPFSALDVHL SDHLMQAGIL ELLRDDKRTV VLVTHKLQYL 900
PHADWIIAMK DGTIQREGTL KDFQRSECQL FEHWKTLMNR QDQELEKETV 950
MERKAPEPSQ GLPRAMSSRD GLLLDEDEEE EEAAESEEDD NLSSVLHQRA 1000
KIPWRACTKY LSSAGVLLLS LLVFSQLLKH MVLVAIDYWL AKWTDSALVL 1050
SPAARNCSLS QECALDQSVY AMVFTVLCSL GIALCLVTSV TVEWTGLKVA 1100
KRLHRSLLNR IILAPMRFFE TTPLGSILNR FSSDCNTIDQ HIPSTLECLS 1150
RSTLLCVSAL TVISYVTPVF LVALLPLAVV CYFIQKYFRV ASRDLQQLDD 1200
TTQLPLLSHF AETVEGLTTI RAFRYEARFQ QKLLEYTDSN NIASLFLTAA 1250
NRWLEVRMEY IGACVVLIAA ATSISNSLHR ELSAGLVGLG LTYALMVSNY 1300
LNWMVRNLAD MEIQLGAVKR IHTLLKTEAE SYEGLLAPSL IPKNWPDQGK 1350
IQIQNLSVRY DSSLKPVLKH VNALIAPGQK IGICGRTGSG KSSFSLAFFR 1400
MVDMFEGRII IDGIDIAKLP LHTLRSRLSI ILQDPVLFSG TIRFNLDPEK 1450
KCSDSTLWEA LEIAQLKLVV KALPGGLDAI ITEGGENFSQ GQRQLFCLAR 1500
AFVRKTSIFI MDEATASIDM ATENILQKVV MTAFADRTVV TIAHRVHTIL 1550
SADLVMVLKR GAILEFDKPE KLLSQKDSVF ASFVRADK 1588
Length:1,588
Mass (Da):178,071
Last modified:July 1, 2008 - v1
Checksum:i661159D6319EFD53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115036 Genomic DNA. No translation available.
AC120135 Genomic DNA. No translation available.
BC141411 mRNA. Translation: AAI41412.1.
RefSeqiNP_035640.2. NM_011510.3.
UniGeneiMm.259076.

Genome annotation databases

EnsembliENSMUST00000033123; ENSMUSP00000033123; ENSMUSG00000040136.
GeneIDi20927.
KEGGimmu:20927.
UCSCiuc009gye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115036 Genomic DNA. No translation available.
AC120135 Genomic DNA. No translation available.
BC141411 mRNA. Translation: AAI41412.1 .
RefSeqi NP_035640.2. NM_011510.3.
UniGenei Mm.259076.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58644N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033123 ; ENSMUSP00000033123 ; ENSMUSG00000040136 .
GeneIDi 20927.
KEGGi mmu:20927.
UCSCi uc009gye.1. mouse.

Organism-specific databases

CTDi 6833.
MGIi MGI:1352629. Abcc8.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117379.
HOVERGENi HBG101342.
InParanoidi B2RUS7.
KOi K05032.
OMAi RKDSVFA.
OrthoDBi EOG7MWGW0.
TreeFami TF105201.

Enzyme and pathway databases

Reactomei REACT_199102. ATP sensitive Potassium channels.

Miscellaneous databases

NextBioi 299841.
PROi B2RUS7.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RUS7.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
IPR000844. Surea_rcpt-1.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
PRINTSi PR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RUS7_MOUSE
AccessioniPrimary (citable) accession number: B2RUS7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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