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B2RUS7

- B2RUS7_MOUSE

UniProt

B2RUS7 - B2RUS7_MOUSE

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Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Gene

Abcc8

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. sulfonylurea receptor activity Source: InterPro

GO - Biological processi

  1. potassium ion transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199102. ATP sensitive Potassium channels.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 8Imported
Submitted name:
Protein Abcc8Imported
Gene namesi
Name:Abcc8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352629. Abcc8.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: MGI
  2. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB2RUS7.

Interactioni

Protein-protein interaction databases

DIPiDIP-58644N.

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00760000119056.
HOVERGENiHBG101342.
KOiK05032.
OMAiRKDSVFA.
OrthoDBiEOG7MWGW0.
TreeFamiTF105201.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
IPR000844. Surea_rcpt-1.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RUS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG
60 70 80 90 100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE
110 120 130 140 150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK
160 170 180 190 200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEINVI RVRRYIFFKT
210 220 230 240 250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HRKPIDLRAI
260 270 280 290 300
GKLPIAMRAL TNYQRLCAAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV
310 320 330 340 350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE
360 370 380 390 400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM
410 420 430 440 450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI
460 470 480 490 500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN
510 520 530 540 550
EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT SISIFMNTAI
560 570 580 590 600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST
610 620 630 640 650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR
660 670 680 690 700
PAREEVRDLL GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT
710 720 730 740 750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QRVSGAVFWN SSLPDSEGED
760 770 780 790 800
PRYCLRTSNP ERETAADSDA RSRGPVAYAS QKPWLLNATV EENITFESPF
810 820 830 840 850
NKQRYKMVIE ACSLQPDIDI LPHGDQTQIG ERGINLSGGQ RQRISVARAL
860 870 880 890 900
YQHTNVVFLD DPFSALDVHL SDHLMQAGIL ELLRDDKRTV VLVTHKLQYL
910 920 930 940 950
PHADWIIAMK DGTIQREGTL KDFQRSECQL FEHWKTLMNR QDQELEKETV
960 970 980 990 1000
MERKAPEPSQ GLPRAMSSRD GLLLDEDEEE EEAAESEEDD NLSSVLHQRA
1010 1020 1030 1040 1050
KIPWRACTKY LSSAGVLLLS LLVFSQLLKH MVLVAIDYWL AKWTDSALVL
1060 1070 1080 1090 1100
SPAARNCSLS QECALDQSVY AMVFTVLCSL GIALCLVTSV TVEWTGLKVA
1110 1120 1130 1140 1150
KRLHRSLLNR IILAPMRFFE TTPLGSILNR FSSDCNTIDQ HIPSTLECLS
1160 1170 1180 1190 1200
RSTLLCVSAL TVISYVTPVF LVALLPLAVV CYFIQKYFRV ASRDLQQLDD
1210 1220 1230 1240 1250
TTQLPLLSHF AETVEGLTTI RAFRYEARFQ QKLLEYTDSN NIASLFLTAA
1260 1270 1280 1290 1300
NRWLEVRMEY IGACVVLIAA ATSISNSLHR ELSAGLVGLG LTYALMVSNY
1310 1320 1330 1340 1350
LNWMVRNLAD MEIQLGAVKR IHTLLKTEAE SYEGLLAPSL IPKNWPDQGK
1360 1370 1380 1390 1400
IQIQNLSVRY DSSLKPVLKH VNALIAPGQK IGICGRTGSG KSSFSLAFFR
1410 1420 1430 1440 1450
MVDMFEGRII IDGIDIAKLP LHTLRSRLSI ILQDPVLFSG TIRFNLDPEK
1460 1470 1480 1490 1500
KCSDSTLWEA LEIAQLKLVV KALPGGLDAI ITEGGENFSQ GQRQLFCLAR
1510 1520 1530 1540 1550
AFVRKTSIFI MDEATASIDM ATENILQKVV MTAFADRTVV TIAHRVHTIL
1560 1570 1580
SADLVMVLKR GAILEFDKPE KLLSQKDSVF ASFVRADK
Length:1,588
Mass (Da):178,071
Last modified:July 1, 2008 - v1
Checksum:i661159D6319EFD53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115036 Genomic DNA. No translation available.
AC120135 Genomic DNA. No translation available.
BC141411 mRNA. Translation: AAI41412.1.
RefSeqiNP_035640.2. NM_011510.3.
UniGeneiMm.259076.

Genome annotation databases

EnsembliENSMUST00000033123; ENSMUSP00000033123; ENSMUSG00000040136.
GeneIDi20927.
KEGGimmu:20927.
UCSCiuc009gye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC115036 Genomic DNA. No translation available.
AC120135 Genomic DNA. No translation available.
BC141411 mRNA. Translation: AAI41412.1 .
RefSeqi NP_035640.2. NM_011510.3.
UniGenei Mm.259076.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58644N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033123 ; ENSMUSP00000033123 ; ENSMUSG00000040136 .
GeneIDi 20927.
KEGGi mmu:20927.
UCSCi uc009gye.1. mouse.

Organism-specific databases

CTDi 6833.
MGIi MGI:1352629. Abcc8.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00760000119056.
HOVERGENi HBG101342.
KOi K05032.
OMAi RKDSVFA.
OrthoDBi EOG7MWGW0.
TreeFami TF105201.

Enzyme and pathway databases

Reactomei REACT_199102. ATP sensitive Potassium channels.

Miscellaneous databases

NextBioi 299841.
PROi B2RUS7.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RUS7.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
IPR000844. Surea_rcpt-1.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
PRINTSi PR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RUS7_MOUSE
AccessioniPrimary (citable) accession number: B2RUS7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3