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B2RUS7

- B2RUS7_MOUSE

UniProt

B2RUS7 - B2RUS7_MOUSE

Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Gene

Abcc8

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. sulfonylurea receptor activity Source: InterPro

    GO - Biological processi

    1. potassium ion transport Source: InterPro

    Keywords - Ligandi

    ATP-bindingUniRule annotationImported, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_199102. ATP sensitive Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-binding cassette, sub-family C (CFTR/MRP), member 8Imported
    Submitted name:
    Protein Abcc8Imported
    Gene namesi
    Name:Abcc8Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352629. Abcc8.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: MGI
    2. voltage-gated potassium channel complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriB2RUS7.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-58644N.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation
    Contains ABC transmembrane type-1 domains.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117379.
    HOVERGENiHBG101342.
    InParanoidiB2RUS7.
    KOiK05032.
    OMAiRKDSVFA.
    OrthoDBiEOG7MWGW0.
    TreeFamiTF105201.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    IPR000388. Sulphorea_rcpt.
    IPR000844. Surea_rcpt-1.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    PRINTSiPR01093. SULFNYLUR1.
    PR01092. SULFNYLUREAR.
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B2RUS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG     50
    WGSQSSKVHI HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE 100
    SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 150
    TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEINVI RVRRYIFFKT 200
    PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HRKPIDLRAI 250
    GKLPIAMRAL TNYQRLCAAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 300
    LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 350
    FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 400
    HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 450
    LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 500
    EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT SISIFMNTAI 550
    PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 600
    VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 650
    PAREEVRDLL GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 700
    IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QRVSGAVFWN SSLPDSEGED 750
    PRYCLRTSNP ERETAADSDA RSRGPVAYAS QKPWLLNATV EENITFESPF 800
    NKQRYKMVIE ACSLQPDIDI LPHGDQTQIG ERGINLSGGQ RQRISVARAL 850
    YQHTNVVFLD DPFSALDVHL SDHLMQAGIL ELLRDDKRTV VLVTHKLQYL 900
    PHADWIIAMK DGTIQREGTL KDFQRSECQL FEHWKTLMNR QDQELEKETV 950
    MERKAPEPSQ GLPRAMSSRD GLLLDEDEEE EEAAESEEDD NLSSVLHQRA 1000
    KIPWRACTKY LSSAGVLLLS LLVFSQLLKH MVLVAIDYWL AKWTDSALVL 1050
    SPAARNCSLS QECALDQSVY AMVFTVLCSL GIALCLVTSV TVEWTGLKVA 1100
    KRLHRSLLNR IILAPMRFFE TTPLGSILNR FSSDCNTIDQ HIPSTLECLS 1150
    RSTLLCVSAL TVISYVTPVF LVALLPLAVV CYFIQKYFRV ASRDLQQLDD 1200
    TTQLPLLSHF AETVEGLTTI RAFRYEARFQ QKLLEYTDSN NIASLFLTAA 1250
    NRWLEVRMEY IGACVVLIAA ATSISNSLHR ELSAGLVGLG LTYALMVSNY 1300
    LNWMVRNLAD MEIQLGAVKR IHTLLKTEAE SYEGLLAPSL IPKNWPDQGK 1350
    IQIQNLSVRY DSSLKPVLKH VNALIAPGQK IGICGRTGSG KSSFSLAFFR 1400
    MVDMFEGRII IDGIDIAKLP LHTLRSRLSI ILQDPVLFSG TIRFNLDPEK 1450
    KCSDSTLWEA LEIAQLKLVV KALPGGLDAI ITEGGENFSQ GQRQLFCLAR 1500
    AFVRKTSIFI MDEATASIDM ATENILQKVV MTAFADRTVV TIAHRVHTIL 1550
    SADLVMVLKR GAILEFDKPE KLLSQKDSVF ASFVRADK 1588
    Length:1,588
    Mass (Da):178,071
    Last modified:July 1, 2008 - v1
    Checksum:i661159D6319EFD53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115036 Genomic DNA. No translation available.
    AC120135 Genomic DNA. No translation available.
    BC141411 mRNA. Translation: AAI41412.1.
    RefSeqiNP_035640.2. NM_011510.3.
    UniGeneiMm.259076.

    Genome annotation databases

    EnsembliENSMUST00000033123; ENSMUSP00000033123; ENSMUSG00000040136.
    GeneIDi20927.
    KEGGimmu:20927.
    UCSCiuc009gye.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115036 Genomic DNA. No translation available.
    AC120135 Genomic DNA. No translation available.
    BC141411 mRNA. Translation: AAI41412.1 .
    RefSeqi NP_035640.2. NM_011510.3.
    UniGenei Mm.259076.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-58644N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033123 ; ENSMUSP00000033123 ; ENSMUSG00000040136 .
    GeneIDi 20927.
    KEGGi mmu:20927.
    UCSCi uc009gye.1. mouse.

    Organism-specific databases

    CTDi 6833.
    MGIi MGI:1352629. Abcc8.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117379.
    HOVERGENi HBG101342.
    InParanoidi B2RUS7.
    KOi K05032.
    OMAi RKDSVFA.
    OrthoDBi EOG7MWGW0.
    TreeFami TF105201.

    Enzyme and pathway databases

    Reactomei REACT_199102. ATP sensitive Potassium channels.

    Miscellaneous databases

    NextBioi 299841.
    PROi B2RUS7.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori B2RUS7.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    IPR000388. Sulphorea_rcpt.
    IPR000844. Surea_rcpt-1.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    PRINTSi PR01093. SULFNYLUR1.
    PR01092. SULFNYLUREAR.
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB2RUS7_MOUSE
    AccessioniPrimary (citable) accession number: B2RUS7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3