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B2RUI1 (ZN551_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 551
Gene names
Name:Znf551
Synonyms:Zfp551
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 13 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696696Zinc finger protein 551
PRO_0000358931

Regions

Domain48 – 11972KRAB
Zinc finger337 – 35923C2H2-type 1
Zinc finger365 – 38723C2H2-type 2
Zinc finger393 – 41523C2H2-type 3
Zinc finger421 – 44323C2H2-type 4
Zinc finger449 – 47123C2H2-type 5
Zinc finger477 – 49923C2H2-type 6
Zinc finger505 – 52723C2H2-type 7
Zinc finger533 – 55523C2H2-type 8
Zinc finger561 – 58323C2H2-type 9
Zinc finger589 – 61123C2H2-type 10
Zinc finger617 – 63923C2H2-type 11
Zinc finger645 – 66723C2H2-type 12
Zinc finger673 – 69523C2H2-type 13

Experimental info

Sequence conflict4211Y → N in BAE23302. Ref.1
Sequence conflict4241S → Y in AAI41161. Ref.3

Sequences

Sequence LengthMass (Da)Tools
B2RUI1 [UniParc].

Last modified January 20, 2009. Version 2.
Checksum: 8F2FE3440507C9DC

FASTA69679,722
        10         20         30         40         50         60 
MPRARPREET SATWSLLPLQ NPMAVAMHRN IAQVPLTSEP VMELGLDVSF EDVAIHFSQE 

        70         80         90        100        110        120 
EWVLLDKAQR LLYCSVMLEN LALVASLGSC TGMGDEDVTC EPAEEVVCNT SPSPQETHLL 

       130        140        150        160        170        180 
EIPVPALEEA WHQNEFLSTQ PVQTLDLSRT GSGLKEDSNR HWKSYSGEKS CERDSHRATA 

       190        200        210        220        230        240 
MSSCRSHGLT EPFIRGKDGE EALSSIAGVQ QQGACHSEQP STGCLQQQAT CIREQPYSSA 

       250        260        270        280        290        300 
KCGQALLNGE KHCKDGECQK GSSCKHTLVQ CPSASSEKRP SECSKYEKAF SCSYKHAQHQ 

       310        320        330        340        350        360 
DSHSGKRTHE HSQHEKPFSK KCRLNTQDRI CPQERPYKCT ECGKAFIYKS ELVYHQRHHS 

       370        380        390        400        410        420 
ARVHYECVEC RKSFTYKSNL TEHQRIHTGE RPYQCEQCGK SFRQNSSLFR HHRIHTGERP 

       430        440        450        460        470        480 
YECSECGKSF RQIFNLIRHR RVHTGEMPHQ CADCGKAFSC KAELSQHERI HSGEKPYECS 

       490        500        510        520        530        540 
ECGKYFRQFS NLIRHRRVHT GDRPYKCSEC EKSFSRKFIL VQHQRVHTGE RPYKCGECGT 

       550        560        570        580        590        600 
SFTRKSDLIQ HQRIHTGTRP YECEECGKSF RQCSSLIQHR RVHTGEKPYE CIECGKAFSQ 

       610        620        630        640        650        660 
SASLIQHQRL HTGERPYECS ECGKSFSQSA SLIQHQRSHS GEKPFECSDC SKPFTHKSDL 

       670        680        690 
IQHRRVHTGE RPYECHDCEK SFSRRSNLVR HQRVHT

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK137311 mRNA. Translation: BAE23302.1.
AC114404 Genomic DNA. No translation available.
BC141160 mRNA. Translation: AAI41161.1.
IPIIPI00465509.
RefSeqNP_001028992.2. NM_001033820.3.
UniGeneMm.361832.

3D structure databases

ProteinModelPortalB2RUI1.
SMRB2RUI1. Positions 257-696.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000079222.

PTM databases

PhosphoSiteB2RUI1.

Proteomic databases

PaxDbB2RUI1.
PRIDEB2RUI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000080348; ENSMUSP00000079222; ENSMUSG00000034071.
GeneID619331.
KEGGmmu:619331.
UCSCuc009fea.3. mouse.

Organism-specific databases

CTD619331.
MGIMGI:3588205. Zfp551.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00700000104146.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidB2RUI1.
KOK09228.
OrthoDBEOG43R3M3.

Gene expression databases

ArrayExpressB2RUI1.
BgeeB2RUI1.
GenevestigatorB2RUI1.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. Krueppel-associated_box. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio414714.
SOURCESearch...

Entry information

Entry nameZN551_MOUSE
AccessionPrimary (citable) accession number: B2RUI1
Secondary accession number(s): Q3UVG7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: May 29, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents