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B2RUG9

- B2RUG9_MOUSE

UniProt

B2RUG9 - B2RUG9_MOUSE

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Protein
Submitted name:

Adenomatosis polyposis coli

Gene
Apc, mCG_121500
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. microtubule plus-end binding Source: MGI
  3. protein binding Source: MGI
  4. protein kinase regulator activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. axis specification Source: MGI
  3. axonogenesis Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  6. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
  7. cell cycle arrest Source: InterPro
  8. cell migration Source: MGI
  9. cellular response to DNA damage stimulus Source: InterPro
  10. chromosome organization Source: MGI
  11. cytoplasmic microtubule organization Source: MGI
  12. dorsal/ventral pattern formation Source: MGI
  13. hair follicle development Source: MGI
  14. kidney development Source: MGI
  15. metaphase/anaphase transition of mitotic cell cycle Source: MGI
  16. mitotic cytokinesis Source: MGI
  17. mitotic spindle assembly checkpoint Source: Ensembl
  18. muscle cell cellular homeostasis Source: MGI
  19. negative regulation of apoptotic process Source: MGI
  20. negative regulation of canonical Wnt signaling pathway Source: MGI
  21. negative regulation of cell proliferation Source: MGI
  22. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  23. negative regulation of epithelial cell proliferation Source: MGI
  24. negative regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
  25. negative regulation of MAPK cascade Source: MGI
  26. negative regulation of microtubule depolymerization Source: MGI
  27. negative regulation of odontogenesis Source: MGI
  28. negative regulation of Wnt signaling pathway Source: MGI
  29. pattern specification process Source: MGI
  30. positive regulation of apoptotic process Source: MGI
  31. positive regulation of cell adhesion Source: MGI
  32. positive regulation of cell differentiation Source: MGI
  33. positive regulation of cell division Source: MGI
  34. positive regulation of cell migration Source: MGI
  35. positive regulation of epithelial cell differentiation Source: MGI
  36. positive regulation of microtubule polymerization Source: MGI
  37. positive regulation of protein catabolic process Source: MGI
  38. positive regulation of pseudopodium assembly Source: Ensembl
  39. protein complex assembly Source: Ensembl
  40. proximal/distal pattern formation Source: MGI
  41. regulation of attachment of spindle microtubules to kinetochore Source: MGI
  42. regulation of cell cycle Source: MGI
  43. regulation of cell differentiation Source: MGI
  44. regulation of cell migration Source: MGI
  45. regulation of epithelial cell differentiation Source: MGI
  46. regulation of nitrogen compound metabolic process Source: MGI
  47. regulation of osteoblast differentiation Source: MGI
  48. regulation of osteoclast differentiation Source: MGI
  49. retina development in camera-type eye Source: MGI
  50. skin development Source: MGI
  51. somatic stem cell maintenance Source: MGI
  52. stem cell maintenance Source: MGI
  53. T cell differentiation in thymus Source: MGI
  54. thymus development Source: MGI
  55. Wnt signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_219771. deactivation of the beta-catenin transactivating complex.
REACT_224460. Apoptotic cleavage of cellular proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenomatosis polyposis coliImported
Submitted name:
Adenomatosis polyposis coli, isoform CRA_aImported
Submitted name:
Adenomatous polyposis coli proteinImported
Gene namesi
Name:ApcImported
ORF Names:mCG_121500Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:88039. Apc.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. axonal growth cone Source: MGI
  3. beta-catenin destruction complex Source: Ensembl
  4. cell-cell adherens junction Source: Ensembl
  5. cell projection Source: MGI
  6. cell projection membrane Source: MGI
  7. centrosome Source: Ensembl
  8. cytoplasm Source: MGI
  9. growth cone Source: MGI
  10. kinetochore Source: Ensembl
  11. lamellipodium Source: Ensembl
  12. lateral plasma membrane Source: Ensembl
  13. nucleus Source: MGI
  14. ruffle membrane Source: Ensembl
  15. tight junction Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB2RUG9.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063749.
HOVERGENiHBG004264.
InParanoidiB2RUG9.
KOiK02085.
OMAiIEDCPIN.
TreeFamiTF106496.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
PfamiPF05972. APC_15aa. 4 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF00514. Arm. 3 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RUG9-1 [UniParc]FASTAAdd to Basket

« Hide

MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ     50
LQGSIEDETM TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS 100
VSSRSGECSP VPMGSFPRRT FVNGSRESTG YLEELEKERS LLLADLDKEE 150
KEKDWYYAQL QNLTKRIDSL PLTENFSLQT DMTRRQLEYE ARQIRAAMEE 200
QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA ERSSQSRHDA 250
ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 300
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC 350
LPLLIQLLHG NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR 400
EIRVLHLLEQ IRAYCETCWE WQEAHEQGMD QDKNPMPAPV EHQICPAVCV 450
LMKLSFDEEH RHAMNELGGL QAIAELLQVD CEMYGLTNDH YSVTLRRYAG 500
MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ VIASVLRNLS 550
WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH 650
RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG 700
AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL 750
HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYAFD 800
ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL 850
ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 900
DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA 950
KVEYKRSSND SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA 1000
DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP 1050
KHVIEDEIKQ NEQRQARSQN TSYPVYSENT DDKHLKFQPH FGQQECVSPY 1100
RSRGTSGSET NRMGSSHAIN QNVNQSLCQE DDYEDDKPTN YSERYSEEEQ 1150
HEEEEERPTN YSIKYNEEKH HVDQPIDYSL KYATDISSSQ KPSFSFSKNS 1200
SAQSTKPEHL SPSSENTAVP PSNAKRQNQL RPSSAQRNGQ TQKGTTCKVP 1250
SINQETIQTY CVEDTPICFS RCSSLSSLSS ADDEIGCDQT TQEADSANTL 1300
QTAEVKENDV TRSAEDPATE VPAVSQNARA KPSRLQASGL SSESTRHNKA 1350
VEFSSGAKSP SKSGAQTPKS PPEHYVQETP LVFSRCTSVS SLDSFESRSI 1400
ASSVQSEPCS GMVSGIISPS DLPDSPGQTM PPSRSKTPPP PPQTVQAKRE 1450
VPKSKVPAAE KRESGPKQTA VNAAVQRVQV LPDVDTLLHF ATESTPDGFS 1500
CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PEESNENQDK 1550
EVEKPDSEKD LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP 1600
PPVARKPSQL PVYKLLPAQN RLQAQKHVSF TPGDDVPRVY CVEGTPINFS 1650
TATSLSDLTI ESPPNELATG DGVRAGIQSG EFEKRDTIPT EGRSTDDAQR 1700
GKISSIVTPD LDDNKAEEGD ILAECINSAM PKGKSHKPFR VKKIMDQVQQ 1750
ASSTSSGANK NQVDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE 1800
ETFSDNKDSK KPSLQTNAKA FNEKLPNNED RVRGSFALDS PHHYTPIEGT 1850
PYCFSRNDSL SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCRPEPNS 1900
SQQAASKSQA SIKHPANRAQ SKPVLQKQPT FPQSSKDGPD RGAATDEKLQ 1950
NFAIENTPVC FSRNSSLSSL SDIDQENNNN KESEPIKEAE PANSQGEPSK 2000
PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE CISSAMPKKK 2050
RPSRLKSESE KQSPRKVGGI LAEDLTLDLK DLQRPDSEHA FSPDSENFDW 2100
KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GISLGSPFHL 2150
TPDQEEKPFT SNKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT 2200
GKIRSNSEIS SQMKQPLPTN MPSISRGRTM IHIPGLRNSS SSTSPVSKKG 2250
PPLKTPASKS PSEGPGATTS PRGTKPAGKS ELSPITRQTS QISGSNKGSS 2300
RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISPPN KLSQLPRTSS 2350
PSTASTKSSG SGKMSYTSPG RQLSQQNLTK QASLSKNASS IPRSESASKG 2400
LNQMSNGNGS NKKVELSRMS STKSSGSESD RSERPALVRQ STFIKEAPSP 2450
TLRRKLEESA SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ 2500
AGGWRKLPPN LSPTIEYNDG RPTKRHDIAR SHSESPSRLP INRAGTWKRE 2550
HSKHSSSLPR VSTWRRTGSS SSILSASSES SEKAKSEDER HVSSMPAPRQ 2600
MKENQVPTKG TWRKIKESDI SPTGMASQSA SSGAASGAES KPLIYQMAPP 2650
VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDT 2700
HGKQSVGSGS PVQTVGLETR LNSFVQVEAP EQKGTEAKPG QSNPVSIAET 2750
AETCIAERTP FSSSSSSKHS SPSGTVAARV TPFNYNPSPR KSSADSTSAR 2800
PSQIPTPVST NTKKRDSKTD STESSGAQSP KRHSGSYLVT SV 2842
Length:2,842
Mass (Da):310,880
Last modified:July 1, 2008 - v1
Checksum:iED681AC077A9F7DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090534 Genomic DNA. No translation available.
AC114003 Genomic DNA. No translation available.
AL591373 Genomic DNA. No translation available.
BC141141 mRNA. Translation: AAI41142.1.
CH466557 Genomic DNA. Translation: EDK97078.1.
RefSeqiNP_031488.2. NM_007462.3.
UniGeneiMm.384171.

Genome annotation databases

EnsembliENSMUST00000079362; ENSMUSP00000078337; ENSMUSG00000005871.
GeneIDi11789.
KEGGimmu:11789.
UCSCiuc008eke.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090534 Genomic DNA. No translation available.
AC114003 Genomic DNA. No translation available.
AL591373 Genomic DNA. No translation available.
BC141141 mRNA. Translation: AAI41142.1 .
CH466557 Genomic DNA. Translation: EDK97078.1 .
RefSeqi NP_031488.2. NM_007462.3.
UniGenei Mm.384171.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079362 ; ENSMUSP00000078337 ; ENSMUSG00000005871 .
GeneIDi 11789.
KEGGi mmu:11789.
UCSCi uc008eke.2. mouse.

Organism-specific databases

CTDi 324.
MGIi MGI:88039. Apc.

Phylogenomic databases

GeneTreei ENSGT00530000063749.
HOVERGENi HBG004264.
InParanoidi B2RUG9.
KOi K02085.
OMAi IEDCPIN.
TreeFami TF106496.

Enzyme and pathway databases

Reactomei REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_219771. deactivation of the beta-catenin transactivating complex.
REACT_224460. Apoptotic cleavage of cellular proteins.

Miscellaneous databases

ChiTaRSi APC. mouse.
NextBioi 279609.
SOURCEi Search...

Gene expression databases

Genevestigatori B2RUG9.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view ]
PANTHERi PTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
Pfami PF05972. APC_15aa. 4 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF00514. Arm. 3 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB2RUG9_MOUSE
AccessioniPrimary (citable) accession number: B2RUG9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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