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Protein

POTE ankyrin domain family member C

Gene

POTEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member C
Alternative name(s):
ANKRD26-like family B member 2
Prostate, ovary, testis-expressed protein on chromosome 18
Short name:
POTE-18
Gene namesi
Name:POTEC
Synonyms:A26B2, POTE18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:33894. POTEC.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724729.

Polymorphism and mutation databases

BioMutaiPOTEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542POTE ankyrin domain family member CPRO_0000345419Add
BLAST

Proteomic databases

EPDiB2RU33.
MaxQBiB2RU33.
PaxDbiB2RU33.
PeptideAtlasiB2RU33.
PRIDEiB2RU33.

PTM databases

iPTMnetiB2RU33.
PhosphoSiteiB2RU33.

Expressioni

Tissue specificityi

Expressed in prostate and testis.1 Publication

Gene expression databases

BgeeiB2RU33.
CleanExiHS_POTEC.
ExpressionAtlasiB2RU33. baseline and differential.
GenevisibleiB2RU33. HS.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

BioGridi132700. 9 interactions.
STRINGi9606.ENSP00000351856.

Structurei

3D structure databases

ProteinModelPortaliB2RU33.
SMRiB2RU33. Positions 143-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati138 – 17134ANK 1Add
BLAST
Repeati172 – 20130ANK 2Add
BLAST
Repeati205 – 23430ANK 3Add
BLAST
Repeati238 – 26730ANK 4Add
BLAST
Repeati271 – 30030ANK 5Add
BLAST
Repeati304 – 33330ANK 6Add
BLAST
Repeati337 – 37337ANK 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili489 – 53850Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the POTE family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IHJ1. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiB2RU33.
KOiK17299.
OrthoDBiEOG7FBRHS.
PhylomeDBiB2RU33.
TreeFamiTF337879.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RU33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKMLRSK MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGAW GDYDDSAFME PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KQKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN TTLHYAVHNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
RSRKPENQQF PDTENEEYHS DEQNDTRKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540
IEVAEKKMNS ELSLSHKKEE DLLRENSMLQ EEIAMLISGD WN
Length:542
Mass (Da):61,188
Last modified:July 22, 2008 - v2
Checksum:iE0268580D8A7F86E
GO

Sequence cautioni

The sequence AAI40941.1 differs from that shown.Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371S → C in AAI40941 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31T → A.1 Publication
Corresponds to variant rs28535987 [ dbSNP | Ensembl ].
VAR_045825
Natural varianti10 – 101A → T.
Corresponds to variant rs45488295 [ dbSNP | Ensembl ].
VAR_045826
Natural varianti13 – 131A → T.
Corresponds to variant rs45561536 [ dbSNP | Ensembl ].
VAR_045827
Natural varianti28 – 281F → C.
Corresponds to variant rs45626231 [ dbSNP | Ensembl ].
VAR_045828
Natural varianti30 – 301H → P.
Corresponds to variant rs9807633 [ dbSNP | Ensembl ].
VAR_045829
Natural varianti36 – 361K → R.
Corresponds to variant rs45570841 [ dbSNP | Ensembl ].
VAR_045830
Natural varianti66 – 661H → R.
Corresponds to variant rs9807555 [ dbSNP | Ensembl ].
VAR_045831
Natural varianti72 – 721C → Y.
Corresponds to variant rs45554841 [ dbSNP | Ensembl ].
VAR_045832
Natural varianti86 – 861H → D.1 Publication
Corresponds to variant rs45469098 [ dbSNP | Ensembl ].
VAR_045833
Natural varianti166 – 1661M → I.
Corresponds to variant rs12454500 [ dbSNP | Ensembl ].
VAR_045834
Natural varianti221 – 2211C → R.
Corresponds to variant rs7505568 [ dbSNP | Ensembl ].
VAR_045835

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006261 Genomic DNA. No translation available.
BC140940 mRNA. Translation: AAI40941.1. Sequence problems.
CCDSiCCDS45835.1.
RefSeqiNP_001131143.1. NM_001137671.1.
UniGeneiHs.454726.

Genome annotation databases

EnsembliENST00000358970; ENSP00000351856; ENSG00000183206.
GeneIDi388468.
KEGGihsa:388468.
UCSCiuc010dln.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006261 Genomic DNA. No translation available.
BC140940 mRNA. Translation: AAI40941.1. Sequence problems.
CCDSiCCDS45835.1.
RefSeqiNP_001131143.1. NM_001137671.1.
UniGeneiHs.454726.

3D structure databases

ProteinModelPortaliB2RU33.
SMRiB2RU33. Positions 143-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132700. 9 interactions.
STRINGi9606.ENSP00000351856.

PTM databases

iPTMnetiB2RU33.
PhosphoSiteiB2RU33.

Polymorphism and mutation databases

BioMutaiPOTEC.

Proteomic databases

EPDiB2RU33.
MaxQBiB2RU33.
PaxDbiB2RU33.
PeptideAtlasiB2RU33.
PRIDEiB2RU33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358970; ENSP00000351856; ENSG00000183206.
GeneIDi388468.
KEGGihsa:388468.
UCSCiuc010dln.4. human.

Organism-specific databases

CTDi388468.
GeneCardsiPOTEC.
H-InvDBHIX0027435.
HGNCiHGNC:33894. POTEC.
HPAiHPA042822.
neXtProtiNX_B2RU33.
PharmGKBiPA164724729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJ1. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiB2RU33.
KOiK17299.
OrthoDBiEOG7FBRHS.
PhylomeDBiB2RU33.
TreeFamiTF337879.

Miscellaneous databases

GenomeRNAii388468.
PROiB2RU33.

Gene expression databases

BgeeiB2RU33.
CleanExiHS_POTEC.
ExpressionAtlasiB2RU33. baseline and differential.
GenevisibleiB2RU33. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-375, VARIANTS ALA-3 AND ASP-86.
  3. "POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer."
    Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Erratum
    Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003)

Entry informationi

Entry nameiPOTEC_HUMAN
AccessioniPrimary (citable) accession number: B2RU33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.