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Protein

POTE ankyrin domain family member C

Gene

POTEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member C
Alternative name(s):
ANKRD26-like family B member 2
Prostate, ovary, testis-expressed protein on chromosome 18
Short name:
POTE-18
Gene namesi
Name:POTEC
Synonyms:A26B2, POTE18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000183206.16.
HGNCiHGNC:33894. POTEC.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183206.
PharmGKBiPA164724729.

Polymorphism and mutation databases

BioMutaiPOTEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003454191 – 542POTE ankyrin domain family member CAdd BLAST542

Proteomic databases

EPDiB2RU33.
MaxQBiB2RU33.
PaxDbiB2RU33.
PRIDEiB2RU33.

PTM databases

iPTMnetiB2RU33.
PhosphoSitePlusiB2RU33.

Expressioni

Tissue specificityi

Expressed in prostate and testis.1 Publication

Gene expression databases

BgeeiENSG00000183206.
CleanExiHS_POTEC.
ExpressionAtlasiB2RU33. baseline and differential.
GenevisibleiB2RU33. HS.

Organism-specific databases

HPAiHPA042822.

Interactioni

Protein-protein interaction databases

BioGridi132700. 10 interactors.
STRINGi9606.ENSP00000351856.

Structurei

3D structure databases

ProteinModelPortaliB2RU33.
SMRiB2RU33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati138 – 171ANK 1Add BLAST34
Repeati172 – 201ANK 2Add BLAST30
Repeati205 – 234ANK 3Add BLAST30
Repeati238 – 267ANK 4Add BLAST30
Repeati271 – 300ANK 5Add BLAST30
Repeati304 – 333ANK 6Add BLAST30
Repeati337 – 373ANK 7Add BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili489 – 538Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the POTE family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IHJ1. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000293138.
InParanoidiB2RU33.
KOiK17299.
OMAiYMASEIG.
PhylomeDBiB2RU33.
TreeFamiTF337879.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 6 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.

Sequencei

Sequence statusi: Complete.

B2RU33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD
60 70 80 90 100
DSFMKMLRSK MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGAW GDYDDSAFME PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVPRKDLIVM LRDTDMNKRD KQKRTALHLA SANGNSEVVQ LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN TTLHYAVHNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICELLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK
410 420 430 440 450
MSQEPEINKD CDREVEEEIK KHGSNPVGLP ENLTNGASAG NGDDGLIPQR
460 470 480 490 500
RSRKPENQQF PDTENEEYHS DEQNDTRKQL SEEQNTGISQ DEILTNKQKQ
510 520 530 540
IEVAEKKMNS ELSLSHKKEE DLLRENSMLQ EEIAMLISGD WN
Length:542
Mass (Da):61,188
Last modified:July 22, 2008 - v2
Checksum:iE0268580D8A7F86E
GO

Sequence cautioni

The sequence AAI40941 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337S → C in AAI40941 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0458253T → A1 PublicationCorresponds to variant dbSNP:rs28535987Ensembl.1
Natural variantiVAR_04582610A → T. Corresponds to variant dbSNP:rs45488295Ensembl.1
Natural variantiVAR_04582713A → T. Corresponds to variant dbSNP:rs45561536Ensembl.1
Natural variantiVAR_04582828F → C. Corresponds to variant dbSNP:rs45626231Ensembl.1
Natural variantiVAR_04582930H → P. Corresponds to variant dbSNP:rs9807633Ensembl.1
Natural variantiVAR_04583036K → R. Corresponds to variant dbSNP:rs45570841Ensembl.1
Natural variantiVAR_04583166H → R. Corresponds to variant dbSNP:rs9807555Ensembl.1
Natural variantiVAR_04583272C → Y. Corresponds to variant dbSNP:rs45554841Ensembl.1
Natural variantiVAR_04583386H → D1 PublicationCorresponds to variant dbSNP:rs45469098Ensembl.1
Natural variantiVAR_045834166M → I. Corresponds to variant dbSNP:rs12454500Ensembl.1
Natural variantiVAR_045835221C → R. Corresponds to variant dbSNP:rs7505568Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006261 Genomic DNA. No translation available.
BC140940 mRNA. Translation: AAI40941.1. Sequence problems.
CCDSiCCDS45835.1.
RefSeqiNP_001131143.1. NM_001137671.1.
UniGeneiHs.454726.

Genome annotation databases

EnsembliENST00000358970; ENSP00000351856; ENSG00000183206.
GeneIDi388468.
KEGGihsa:388468.
UCSCiuc010dln.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPOTEC_HUMAN
AccessioniPrimary (citable) accession number: B2RU33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 27, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families