B2RU33 (POTEC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POTE ankyrin domain family member C

Alternative name(s):
ANKRD26-like family B member 2
Prostate, ovary, testis-expressed protein on chromosome 18
Short name=POTE-18

Gene names

Name:	POTEC
Synonyms:	A26B2, POTE18

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	542 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in prostate and testis. Ref.3
Sequence similarities	Belongs to the POTE family. Contains 7 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B2RU33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B2RU33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     376-381: EQDLKL → GKEAEE
     382-542: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 542	542	POTE ankyrin domain family member C		PRO_0000345419
Regions
	Repeat	138 – 171	34	ANK 1
	Repeat	172 – 201	30	ANK 2
	Repeat	205 – 234	30	ANK 3
	Repeat	238 – 267	30	ANK 4
	Repeat	271 – 300	30	ANK 5
	Repeat	304 – 333	30	ANK 6
	Repeat	337 – 373	37	ANK 7
	Coiled coil	489 – 538	50	Potential
Natural variations
	Alternative sequence	376 – 381	6	EQDLKL → GKEAEE in isoform 2.		VSP_034947
	Alternative sequence	382 – 542	161	Missing in isoform 2.		VSP_034948
	Natural variant	3	1	T → A. Ref.2 Corresponds to variant rs28535987 [ dbSNP | Ensembl ].		VAR_045825
	Natural variant	10	1	A → T. Corresponds to variant rs45488295 [ dbSNP | Ensembl ].		VAR_045826
	Natural variant	13	1	A → T. Corresponds to variant rs45561536 [ dbSNP | Ensembl ].		VAR_045827
	Natural variant	28	1	F → C. Corresponds to variant rs45626231 [ dbSNP | Ensembl ].		VAR_045828
	Natural variant	30	1	H → P. Corresponds to variant rs9807633 [ dbSNP | Ensembl ].		VAR_045829
	Natural variant	36	1	K → R. Corresponds to variant rs45570841 [ dbSNP | Ensembl ].		VAR_045830
	Natural variant	66	1	H → R. Corresponds to variant rs9807555 [ dbSNP | Ensembl ].		VAR_045831
	Natural variant	72	1	C → Y. Corresponds to variant rs45554841 [ dbSNP | Ensembl ].		VAR_045832
	Natural variant	86	1	H → D. Ref.2 Corresponds to variant rs45469098 [ dbSNP | Ensembl ].		VAR_045833
	Natural variant	166	1	M → I. Corresponds to variant rs12454500 [ dbSNP | Ensembl ].		VAR_045834
	Natural variant	221	1	C → R. Corresponds to variant rs7505568 [ dbSNP | Ensembl ].		VAR_045835
Experimental info
	Sequence conflict	337	1	S → C in AAI40941. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: E0268580D8A7F86E	FASTA	542	61,188
	10 20 30 40 50 60 MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD DSFMKMLRSK 70 80 90 100 110 120 MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW 130 140 150 160 170 180 GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA 190 200 210 220 230 240 SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN 250 260 270 280 290 300 TTLHYAVHNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA 310 320 330 340 350 360 LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY 370 380 390 400 410 420 KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK 430 440 450 460 470 480 KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL 490 500 510 520 530 540 SEEQNTGISQ DEILTNKQKQ IEVAEKKMNS ELSLSHKKEE DLLRENSMLQ EEIAMLISGD WN
	Isoform 2 [UniParc]. Checksum: F23B4237367D34A4	FASTA	381	42,700
	10 20 30 40 50 60 MVTEVCSMPA ASAVKKPFDL RSKMGKWFHH RFPCCKGSGK SNMGTSGDHD DSFMKMLRSK 70 80 90 100 110 120 MGKCCHHCFP CCRGSGTSNV GTSGDHDNSF MKTLRSKMGK WCCHCFPCCR GSGKSNVGAW 130 140 150 160 170 180 GDYDDSAFME PRYHVRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KQKRTALHLA 190 200 210 220 230 240 SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CVLMLLEHGA DQNIPDEYGN 250 260 270 280 290 300 TTLHYAVHNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNA 310 320 330 340 350 360 LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY 370 380 KEKQMLKISS ENSNPGKEAE E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ALA-3 AND ASP-86.
[3]	"POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer." Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002) [PubMed: 12475935] [Abstract] Cited for: TISSUE SPECIFICITY.
[4]	Erratum Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V., Lee B., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006261 Genomic DNA. No translation available. BC140940 mRNA. Translation: AAI40941.1.
IPI	IPI00915457. IPI00964539.
RefSeq	NP_001131143.1. NM_001137671.1.
UniGene	Hs.454726.
3D structure databases
ProteinModelPortal	B2RU33.
SMR	B2RU33. Positions 101-366.
ModBase	Search...
Protein-protein interaction databases
STRING	B2RU33.
Proteomic databases
PRIDE	B2RU33.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358970; ENSP00000351856; ENSG00000183206.
GeneID	388468.
KEGG	hsa:388468.
UCSC	uc010dln.1. human.
Organism-specific databases
CTD	388468.
GeneCards	GC18M014505.
HGNC	HGNC:33894. POTEC.
neXtProt	NX_B2RU33.
PharmGKB	PA164724729.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000076605.
InParanoid	B2RU33.
OrthoDB	EOG4SN1NB.
PhylomeDB	B2RU33.
Gene expression databases
CleanEx	HS_POTEC.
Genevestigator	B2RU33.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 2 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POTEC_HUMAN

Accession

Primary (citable) accession number: B2RU33

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.