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Protein
Submitted name:

EIF4G1 protein

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • RNA binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EIF4G1 proteinImported
Gene namesi
Name:EIF4G1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: AgBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB2RU06.
PRIDEiB2RU06.

Expressioni

Gene expression databases

GenevisibleiB2RU06. HS.

Interactioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase

Protein-protein interaction databases

STRINGi9606.ENSP00000338020.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1248 – 1370123MIInterPro annotationAdd
BLAST
Domaini1440 – 1606167W2InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
HOVERGENiHBG052083.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RU06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG
60 70 80 90 100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ
110 120 130 140 150
ISYPASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG
160 170 180 190 200
AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT
210 220 230 240 250
EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD DRSQGAIIAD
260 270 280 290 300
RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI
310 320 330 340 350
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS
360 370 380 390 400
PLQAPTPLAS HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP
410 420 430 440 450
IAPTAQPEEL LNGAPSPPAV DLSPVSEPEE QAKEVTASVA PPTIPSATPA
460 470 480 490 500
TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE AESEKGGEEL LPPESTPIPA
510 520 530 540 550
NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEANPAVPE
560 570 580 590 600
VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK
610 620 630 640 650
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK
660 670 680 690 700
ANKTPLRPLD PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP
710 720 730 740 750
RGPAGLGPRR SQQGPRKEPR KIIATVLMTE DIKLNKAEKA WKPSSKRTAA
760 770 780 790 800
DKDRGEEDAD GSKTQDLFRR VRSILNKLTP QMFQQLMKQV TQLAIDTEER
810 820 830 840 850
LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP TVTVNFRKLL
860 870 880 890 900
LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR
910 920 930 940 950
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG
960 970 980 990 1000
KDLDFEKAKP RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR
1010 1020 1030 1040 1050
RGDQGPKTID QIHKEAEMEE HREHIKVQQL MAKGSDKRRG GPPGPPISRG
1060 1070 1080 1090 1100
LPLVDDGGWN TVPISKGSRP IDTSRLTKIT KPGSIDSNNQ LFAPGGRLSW
1110 1120 1130 1140 1150
GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE STDNRRVVQR
1160 1170 1180 1190 1200
SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER
1210 1220 1230 1240 1250
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE
1260 1270 1280 1290 1300
KKSKAIIEEY LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA
1310 1320 1330 1340 1350
REHMGQLLHQ LLCAGHLSTA QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL
1360 1370 1380 1390 1400
VTPILQEGGV PMGELFREIT KPLRPLGKAA SLLLEILGLL CKSMGPKKVG
1410 1420 1430 1440 1450
TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP GQRALPSEEL
1460 1470 1480 1490 1500
NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF
1510 1520 1530 1540 1550
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR
1560 1570 1580 1590 1600
MFFDALYDED VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE

EESDHN
Length:1,606
Mass (Da):176,175
Last modified:July 1, 2008 - v1
Checksum:i0A8B1B889D6D7A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140892 mRNA. Translation: AAI40893.1.
RefSeqiNP_001181875.1. NM_001194946.1.
UniGeneiHs.433750.

Genome annotation databases

GeneIDi1981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140892 mRNA. Translation: AAI40893.1.
RefSeqiNP_001181875.1. NM_001194946.1.
UniGeneiHs.433750.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338020.

Proteomic databases

PaxDbiB2RU06.
PRIDEiB2RU06.

Protocols and materials databases

DNASUi1981.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1981.

Organism-specific databases

CTDi1981.

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
HOVERGENiHBG052083.

Miscellaneous databases

ChiTaRSiEIF4G1. human.
GenomeRNAii1981.

Gene expression databases

GenevisibleiB2RU06. HS.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiB2RU06_HUMAN
AccessioniPrimary (citable) accession number: B2RU06
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.