B2RTY4 (MYO9A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-IXa

Alternative name(s):
Unconventional myosin-9a

Gene names

Name:	MYO9A
Synonyms:	MYR7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2548 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Found to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver. Isoform 5 was found in leukocytes but not in brain, retina or testis. Ref.1
Sequence similarities	Contains 5 IQ domains. Contains 2 myosin head-like domains. Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 Ras-associating domain. Contains 1 Rho-GAP domain.
Caution	Represents a unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).
Sequence caution	The sequence BAA91979.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14517.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Transmembrane Transmembrane helix Zinc-finger
Ligand	ATP-binding Actin-binding Metal-binding Nucleotide-binding Zinc
Molecular function	GTPase activation Motor protein Myosin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome visual perception Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytosol Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW unconventional myosin complex Non-traceable author statement Ref.7. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B2RTY4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B2RTY4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     367-385: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: B2RTY4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     729-729: H → K
     730-2548: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: B2RTY4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1714-1714: E → EVARPAHKKKARMARTRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQASHCELGPAPSLGQASHSDSEM

Isoform 5 (identifier: B2RTY4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     45-280: Missing.

Note: Lacks the ATP-binding domain which suggests that it cannot interact with actin.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2548	2548	Unconventional myosin-IXa		PRO_0000348440
Regions
	Transmembrane	175 – 195	21	Helical; Potential
	Domain	14 – 112	99	Ras-associating
	Domain	148 – 690	543	Myosin head-like 1
	Domain	884 – 1005	122	Myosin head-like 2
	Domain	1021 – 1041	21	IQ 1
	Domain	1042 – 1071	30	IQ 2
	Domain	1074 – 1103	30	IQ 3
	Domain	1115 – 1144	30	IQ 4
	Domain	1138 – 1167	30	IQ 5
	Domain	2063 – 2251	189	Rho-GAP
	Nucleotide binding	239 – 246	8	ATP Potential
	Zinc finger	1999 – 2048	50	Phorbol-ester/DAG-type 1
	Zinc finger	2068 – 2119	52	Phorbol-ester/DAG-type 2
	Region	907 – 918	12	Actin-binding By similarity
	Region	1021 – 1162	142	Neck or regulatory domain
	Region	1163 – 2511	1349	Tail
	Coiled coil	1264 – 1291	28	Potential
	Coiled coil	1486 – 1532	47	Potential
	Coiled coil	2315 – 2358	44	Potential
Amino acid modifications
	Modified residue	770	1	Phosphothreonine By similarity
	Modified residue	1258	1	Phosphoserine By similarity
	Modified residue	1829	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	45 – 280	236	Missing in isoform 5.		VSP_035156
	Alternative sequence	367 – 385	19	Missing in isoform 2.		VSP_035157
	Alternative sequence	729	1	H → K in isoform 3.		VSP_035158
	Alternative sequence	730 – 2548	1819	Missing in isoform 3.		VSP_035159
	Alternative sequence	1714	1	E → EVARPAHKKKARMARTRSDF LTRGTFADGEGDTEEDDYDD IIEPLLSLDQASHCELGPAP SLGQASHSDSEM in isoform 4.		VSP_035160
	Natural variant	37	1	R → K. Ref.4 Corresponds to variant rs17855105 [ dbSNP | Ensembl ].		VAR_046165
	Natural variant	85	1	R → Q. Ref.1		VAR_046166
	Natural variant	161	1	T → I. Corresponds to variant rs2929516 [ dbSNP | Ensembl ].		VAR_046167
	Natural variant	168	1	N → D. Ref.1		VAR_046168
	Natural variant	211	1	L → P. Ref.1		VAR_046169
	Natural variant	825	1	A → V. Corresponds to variant rs11637562 [ dbSNP | Ensembl ].		VAR_056189
	Natural variant	946	1	R → Q. Ref.1		VAR_046170
	Natural variant	1193	1	G → E. Ref.1 Ref.3 Ref.4 Ref.6 Corresponds to variant rs2415129 [ dbSNP | Ensembl ].		VAR_046171
	Natural variant	1362	1	S → P. Ref.1 Corresponds to variant rs55738821 [ dbSNP | Ensembl ].		VAR_046172
	Natural variant	1476	1	P → R. Corresponds to variant rs16956375 [ dbSNP | Ensembl ].		VAR_046173
	Natural variant	1795	1	H → Y. Corresponds to variant rs16956367 [ dbSNP | Ensembl ].		VAR_046174
	Natural variant	1805	1	H → Q. Corresponds to variant rs2306575 [ dbSNP | Ensembl ].		VAR_046175
	Natural variant	1834	1	R → C. Ref.1		VAR_046176
	Natural variant	2390	1	I → V. Corresponds to variant rs2291280 [ dbSNP | Ensembl ].		VAR_046177
Experimental info
	Sequence conflict	88	1	L → R in CAA04947. Ref.5
	Sequence conflict	94	1	L → Q in CAA04947. Ref.5
	Sequence conflict	104	1	R → H in CAA04947. Ref.5
	Sequence conflict	206	1	H → R in CAA04947. Ref.5
	Sequence conflict	394	1	D → N in CAA04947. Ref.5
	Sequence conflict	424	1	S → P in CAA04947. Ref.5
	Sequence conflict	504	1	S → C in CAA04947. Ref.5
	Sequence conflict	573	1	E → D in CAA04947. Ref.5
	Sequence conflict	595	1	C → Y in CAA04947. Ref.5
	Sequence conflict	694	1	I → M in CAA04947. Ref.5
	Sequence conflict	705	1	L → I in CAA04947. Ref.5
	Sequence conflict	1591	1	S → P in BAB14517. Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 867835BD2B841C84	FASTA	2,548	292,706
	10 20 30 40 50 60 MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEVIESLI NKLHLDKTKC 70 80 90 100 110 120 YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG EDYRFLLREK NLDGSIHYGS 130 140 150 160 170 180 LQSWLRVTEE RRRMMERGFL PQPQQKDFDD LCSLPDLNEK TLLENLRNRF KHEKIYTYVG 190 200 210 220 230 240 SILIVINPFK FLPIYNPKYV KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEDER SAFHLKQPEE 370 380 390 400 410 420 YHYLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE RLQLAMEMVG FLPKTRRQIF 430 440 450 460 470 480 SLLSAILHLG NICYKKKTYR DDSIDICNPE VLPIVSELLE VKEEMLFEAL VTRKTVTVGE 490 500 510 520 530 540 KLILPYKLAE AVTVRNSMAK SLYSALFDWI VFRINHALLN SKDLEHNTKT LSIGVLDIFG 550 560 570 580 590 600 FEDYENNSFE QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS 610 620 630 640 650 660 KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEDNSYIEF PAVMEPAFII KHYAGKVKYG 670 680 690 700 710 720 VKDFREKNTD HMRPDIVALL RSSKNAFISG MIGIDPVAVF RWAILRAFFR AMVAFREAGK 730 740 750 760 770 780 RNIHRKTGHD DTAPCAILKS MDSFSFLQHP VHQRSLEILQ RCKEEKYSIT RKNPRTPLSD 790 800 810 820 830 840 LQGMNALNEK NQHDTFDIAW NGRTGIRQSR LSSGTSLLDK DGIFANSTSS KLLERAHGIL 850 860 870 880 890 900 TRNKNFKSKP ALPKHLLEVN SLKHLTRLTL QDRITKSLLH LHKKKKPPSI SAQFQASLSK 910 920 930 940 950 960 LMETLGQAEP YFVKCIRSNA EKLPLRFSDV LVLRQLRYTG MLETVRIRQS GYSSKYSFQD 970 980 990 1000 1010 1020 FVSHFHVLLP RNIIPSKFNI QDFFRKINLN PDNYQVGKTM VFLKEQERQH LQDLLHQEVL 1030 1040 1050 1060 1070 1080 RRIILLQRWF RVLLCRQHFL HLRQASVIIQ RFWRNYLNQK QVRDAAVQKD AFVMASAAAL 1090 1100 1110 1120 1130 1140 LQASWRAHLE RQRYLELRAA AIVIQQKWRD YYRRRHMAAI CIQARWKAYR ESKRYQEQRK 1150 1160 1170 1180 1190 1200 KIILLQSTCR GFRARQRFKA LKEQRLRETK PEVGLVNIKG YGSLEIQGSD PSGWEDCSFD 1210 1220 1230 1240 1250 1260 NRIKAIEECK SVIESNRISR ESSVDCLKES PNKQQERAQS QSGVDLQEDV LVRERPRSLE 1270 1280 1290 1300 1310 1320 DLHQKKVGRA KRESRRMREL EQAIFSLELL KVRSLGGISP SEDRRWSTEL VPEGLQSPRG 1330 1340 1350 1360 1370 1380 TPDSESSQGS LELLSYEESQ KSKLESVISD EGDLQFPSPK ISSSPKFDSR DNALSASNET 1390 1400 1410 1420 1430 1440 SSAEHLKDGT MKEMVVCSSE SITCKPQLKD SFISNSLPTF FYIPQQDPLK TNSQLDTSIQ 1450 1460 1470 1480 1490 1500 RNKLLENEDT AGEALTLDIN RETRRYHCSG KDQIVPSLNT ESSNPVLKKL EKLNTEKEER 1510 1520 1530 1540 1550 1560 QKQLQQQNEK EMMEQIRQQT DILEKERKAF KTIEKPRIGE CLVAPSSYQS KQRVERPSSL 1570 1580 1590 1600 1610 1620 LSLNTSNKGE LNVLGSLSLK DAALAQKDSS SAHLPPKDRP VTVFFERKGS PCQSSTVKEL 1630 1640 1650 1660 1670 1680 SKTDRMGTQL NVACKLSNNR ISKREHFRPT QSYSHNSDDL SREGNARPIF FTPKDNMSIP 1690 1700 1710 1720 1730 1740 LVSKEALNSK NPQLHKEDEP AWKPVKLAGP GQRETSQRFS SVDEQAKLHK TMSQGEITKL 1750 1760 1770 1780 1790 1800 AVRQKASDSD IRPQRAKMRF WAKGKQGEKK TTRVKPTTQS EVSPLFAGTD VIPAHQFPDE 1810 1820 1830 1840 1850 1860 LAAYHPTPPL SPELPGSCRK EFKENKEPSP KAKRKRSVKI SNVALDSMHW QNDSVQIIAS 1870 1880 1890 1900 1910 1920 VSDLKSMDEF LLKKVNDLDN EDSKKDTLVD VVFKKALKEF RQNIFSFYSS ALAMDDGKSI 1930 1940 1950 1960 1970 1980 RYKDLYALFE QILEKTMRLE QRDSLGESPV RVWVNTFKVF LDEYMNEFKT SDCTATKVPK 1990 2000 2010 2020 2030 2040 TERKKRRKKE TDLVEEHNGH IFKATQYSIP TYCEYCSSLI WIMDRASVCK LCKYACHKKC 2050 2060 2070 2080 2090 2100 CLKTTAKCSK KYDPELSSRQ FGVELSRLTS EDRTVPLVVE KLINYIEMHG LYTEGIYRKS 2110 2120 2130 2140 2150 2160 GSTNKIKELR QGLDTDAESV NLDDYNIHVI ASVFKQWLRD LPNPLMTFEL YEEFLRAMGL 2170 2180 2190 2200 2210 2220 QERKETIRGV YSVIDQLSRT HLNTLERLIF HLVRIALQED TNRMSANALA IVFAPCILRC 2230 2240 2250 2260 2270 2280 PDTTDPLQSV QDISKTTTCV ELIVVEQMNK YKARLKDISS LEFAENKAKT RLSLIRRSMG 2290 2300 2310 2320 2330 2340 KGRIRRGNYP GPSSPVVVRL PSVSDVSEET LTSEAAMETD ITEQQQAAMQ QEERVLTEQI 2350 2360 2370 2380 2390 2400 ENLQKEKEEL TFEMLVLEPR ASDDETLESE ASIGTADSSE NLNMESEYAI SEKSERSLAL 2410 2420 2430 2440 2450 2460 SSLKTAGKSE PSSKLRKQLK KQQDSLDVVD SSVSSLCLSN TASSHGTRKL FQIYSKSPFY 2470 2480 2490 2500 2510 2520 RAASGNEALG MEGPLGQTKF LEDKPQFISR GTFNPEKGKQ KLKNVKNSPQ KTKETPEGTV 2530 2540 MSGRRKTVDP DCTSNQQLAL FGNNEFMV
	Isoform 2 [UniParc]. Checksum: 6024586FEA633B1C	FASTA	2,529	290,379
	10 20 30 40 50 60 MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEVIESLI NKLHLDKTKC 70 80 90 100 110 120 YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG EDYRFLLREK NLDGSIHYGS 130 140 150 160 170 180 LQSWLRVTEE RRRMMERGFL PQPQQKDFDD LCSLPDLNEK TLLENLRNRF KHEKIYTYVG 190 200 210 220 230 240 SILIVINPFK FLPIYNPKYV KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEDER SAFHLKQPEE 370 380 390 400 410 420 YHYLNQDCFT VEGEDLRHDF ERLQLAMEMV GFLPKTRRQI FSLLSAILHL GNICYKKKTY 430 440 450 460 470 480 RDDSIDICNP EVLPIVSELL EVKEEMLFEA LVTRKTVTVG EKLILPYKLA EAVTVRNSMA 490 500 510 520 530 540 KSLYSALFDW IVFRINHALL NSKDLEHNTK TLSIGVLDIF GFEDYENNSF EQFCINFANE 550 560 570 580 590 600 RLQHYFNQHI FKLEQEEYRT EGISWHNIDY IDNTCCINLI SKKPTGLLHL LDEESNFPQA 610 620 630 640 650 660 TNQTLLDKFK HQHEDNSYIE FPAVMEPAFI IKHYAGKVKY GVKDFREKNT DHMRPDIVAL 670 680 690 700 710 720 LRSSKNAFIS GMIGIDPVAV FRWAILRAFF RAMVAFREAG KRNIHRKTGH DDTAPCAILK 730 740 750 760 770 780 SMDSFSFLQH PVHQRSLEIL QRCKEEKYSI TRKNPRTPLS DLQGMNALNE KNQHDTFDIA 790 800 810 820 830 840 WNGRTGIRQS RLSSGTSLLD KDGIFANSTS SKLLERAHGI LTRNKNFKSK PALPKHLLEV 850 860 870 880 890 900 NSLKHLTRLT LQDRITKSLL HLHKKKKPPS ISAQFQASLS KLMETLGQAE PYFVKCIRSN 910 920 930 940 950 960 AEKLPLRFSD VLVLRQLRYT GMLETVRIRQ SGYSSKYSFQ DFVSHFHVLL PRNIIPSKFN 970 980 990 1000 1010 1020 IQDFFRKINL NPDNYQVGKT MVFLKEQERQ HLQDLLHQEV LRRIILLQRW FRVLLCRQHF 1030 1040 1050 1060 1070 1080 LHLRQASVII QRFWRNYLNQ KQVRDAAVQK DAFVMASAAA LLQASWRAHL ERQRYLELRA 1090 1100 1110 1120 1130 1140 AAIVIQQKWR DYYRRRHMAA ICIQARWKAY RESKRYQEQR KKIILLQSTC RGFRARQRFK 1150 1160 1170 1180 1190 1200 ALKEQRLRET KPEVGLVNIK GYGSLEIQGS DPSGWEDCSF DNRIKAIEEC KSVIESNRIS 1210 1220 1230 1240 1250 1260 RESSVDCLKE SPNKQQERAQ SQSGVDLQED VLVRERPRSL EDLHQKKVGR AKRESRRMRE 1270 1280 1290 1300 1310 1320 LEQAIFSLEL LKVRSLGGIS PSEDRRWSTE LVPEGLQSPR GTPDSESSQG SLELLSYEES 1330 1340 1350 1360 1370 1380 QKSKLESVIS DEGDLQFPSP KISSSPKFDS RDNALSASNE TSSAEHLKDG TMKEMVVCSS 1390 1400 1410 1420 1430 1440 ESITCKPQLK DSFISNSLPT FFYIPQQDPL KTNSQLDTSI QRNKLLENED TAGEALTLDI 1450 1460 1470 1480 1490 1500 NRETRRYHCS GKDQIVPSLN TESSNPVLKK LEKLNTEKEE RQKQLQQQNE KEMMEQIRQQ 1510 1520 1530 1540 1550 1560 TDILEKERKA FKTIEKPRIG ECLVAPSSYQ SKQRVERPSS LLSLNTSNKG ELNVLGSLSL 1570 1580 1590 1600 1610 1620 KDAALAQKDS SSAHLPPKDR PVTVFFERKG SPCQSSTVKE LSKTDRMGTQ LNVACKLSNN 1630 1640 1650 1660 1670 1680 RISKREHFRP TQSYSHNSDD LSREGNARPI FFTPKDNMSI PLVSKEALNS KNPQLHKEDE 1690 1700 1710 1720 1730 1740 PAWKPVKLAG PGQRETSQRF SSVDEQAKLH KTMSQGEITK LAVRQKASDS DIRPQRAKMR 1750 1760 1770 1780 1790 1800 FWAKGKQGEK KTTRVKPTTQ SEVSPLFAGT DVIPAHQFPD ELAAYHPTPP LSPELPGSCR 1810 1820 1830 1840 1850 1860 KEFKENKEPS PKAKRKRSVK ISNVALDSMH WQNDSVQIIA SVSDLKSMDE FLLKKVNDLD 1870 1880 1890 1900 1910 1920 NEDSKKDTLV DVVFKKALKE FRQNIFSFYS SALAMDDGKS IRYKDLYALF EQILEKTMRL 1930 1940 1950 1960 1970 1980 EQRDSLGESP VRVWVNTFKV FLDEYMNEFK TSDCTATKVP KTERKKRRKK ETDLVEEHNG 1990 2000 2010 2020 2030 2040 HIFKATQYSI PTYCEYCSSL IWIMDRASVC KLCKYACHKK CCLKTTAKCS KKYDPELSSR 2050 2060 2070 2080 2090 2100 QFGVELSRLT SEDRTVPLVV EKLINYIEMH GLYTEGIYRK SGSTNKIKEL RQGLDTDAES 2110 2120 2130 2140 2150 2160 VNLDDYNIHV IASVFKQWLR DLPNPLMTFE LYEEFLRAMG LQERKETIRG VYSVIDQLSR 2170 2180 2190 2200 2210 2220 THLNTLERLI FHLVRIALQE DTNRMSANAL AIVFAPCILR CPDTTDPLQS VQDISKTTTC 2230 2240 2250 2260 2270 2280 VELIVVEQMN KYKARLKDIS SLEFAENKAK TRLSLIRRSM GKGRIRRGNY PGPSSPVVVR 2290 2300 2310 2320 2330 2340 LPSVSDVSEE TLTSEAAMET DITEQQQAAM QQEERVLTEQ IENLQKEKEE LTFEMLVLEP 2350 2360 2370 2380 2390 2400 RASDDETLES EASIGTADSS ENLNMESEYA ISEKSERSLA LSSLKTAGKS EPSSKLRKQL 2410 2420 2430 2440 2450 2460 KKQQDSLDVV DSSVSSLCLS NTASSHGTRK LFQIYSKSPF YRAASGNEAL GMEGPLGQTK 2470 2480 2490 2500 2510 2520 FLEDKPQFIS RGTFNPEKGK QKLKNVKNSP QKTKETPEGT VMSGRRKTVD PDCTSNQQLA LFGNNEFMV
	Isoform 3 [UniParc]. Checksum: C7529CD8EB711767	FASTA	729	84,679
	10 20 30 40 50 60 MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEVIESLI NKLHLDKTKC 70 80 90 100 110 120 YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG EDYRFLLREK NLDGSIHYGS 130 140 150 160 170 180 LQSWLRVTEE RRRMMERGFL PQPQQKDFDD LCSLPDLNEK TLLENLRNRF KHEKIYTYVG 190 200 210 220 230 240 SILIVINPFK FLPIYNPKYV KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEDER SAFHLKQPEE 370 380 390 400 410 420 YHYLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE RLQLAMEMVG FLPKTRRQIF 430 440 450 460 470 480 SLLSAILHLG NICYKKKTYR DDSIDICNPE VLPIVSELLE VKEEMLFEAL VTRKTVTVGE 490 500 510 520 530 540 KLILPYKLAE AVTVRNSMAK SLYSALFDWI VFRINHALLN SKDLEHNTKT LSIGVLDIFG 550 560 570 580 590 600 FEDYENNSFE QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS 610 620 630 640 650 660 KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEDNSYIEF PAVMEPAFII KHYAGKVKYG 670 680 690 700 710 720 VKDFREKNTD HMRPDIVALL RSSKNAFISG MIGIDPVAVF RWAILRAFFR AMVAFREAGK RNIHRKTGK
	Isoform 4 [UniParc]. Checksum: E19A84D21D057FB0	FASTA	2,619	300,433
	10 20 30 40 50 60 MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEVIESLI NKLHLDKTKC 70 80 90 100 110 120 YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG EDYRFLLREK NLDGSIHYGS 130 140 150 160 170 180 LQSWLRVTEE RRRMMERGFL PQPQQKDFDD LCSLPDLNEK TLLENLRNRF KHEKIYTYVG 190 200 210 220 230 240 SILIVINPFK FLPIYNPKYV KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE 250 260 270 280 290 300 SGSGKTQSTN FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI 310 320 330 340 350 360 QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEDER SAFHLKQPEE 370 380 390 400 410 420 YHYLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE RLQLAMEMVG FLPKTRRQIF 430 440 450 460 470 480 SLLSAILHLG NICYKKKTYR DDSIDICNPE VLPIVSELLE VKEEMLFEAL VTRKTVTVGE 490 500 510 520 530 540 KLILPYKLAE AVTVRNSMAK SLYSALFDWI VFRINHALLN SKDLEHNTKT LSIGVLDIFG 550 560 570 580 590 600 FEDYENNSFE QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS 610 620 630 640 650 660 KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEDNSYIEF PAVMEPAFII KHYAGKVKYG 670 680 690 700 710 720 VKDFREKNTD HMRPDIVALL RSSKNAFISG MIGIDPVAVF RWAILRAFFR AMVAFREAGK 730 740 750 760 770 780 RNIHRKTGHD DTAPCAILKS MDSFSFLQHP VHQRSLEILQ RCKEEKYSIT RKNPRTPLSD 790 800 810 820 830 840 LQGMNALNEK NQHDTFDIAW NGRTGIRQSR LSSGTSLLDK DGIFANSTSS KLLERAHGIL 850 860 870 880 890 900 TRNKNFKSKP ALPKHLLEVN SLKHLTRLTL QDRITKSLLH LHKKKKPPSI SAQFQASLSK 910 920 930 940 950 960 LMETLGQAEP YFVKCIRSNA EKLPLRFSDV LVLRQLRYTG MLETVRIRQS GYSSKYSFQD 970 980 990 1000 1010 1020 FVSHFHVLLP RNIIPSKFNI QDFFRKINLN PDNYQVGKTM VFLKEQERQH LQDLLHQEVL 1030 1040 1050 1060 1070 1080 RRIILLQRWF RVLLCRQHFL HLRQASVIIQ RFWRNYLNQK QVRDAAVQKD AFVMASAAAL 1090 1100 1110 1120 1130 1140 LQASWRAHLE RQRYLELRAA AIVIQQKWRD YYRRRHMAAI CIQARWKAYR ESKRYQEQRK 1150 1160 1170 1180 1190 1200 KIILLQSTCR GFRARQRFKA LKEQRLRETK PEVGLVNIKG YGSLEIQGSD PSGWEDCSFD 1210 1220 1230 1240 1250 1260 NRIKAIEECK SVIESNRISR ESSVDCLKES PNKQQERAQS QSGVDLQEDV LVRERPRSLE 1270 1280 1290 1300 1310 1320 DLHQKKVGRA KRESRRMREL EQAIFSLELL KVRSLGGISP SEDRRWSTEL VPEGLQSPRG 1330 1340 1350 1360 1370 1380 TPDSESSQGS LELLSYEESQ KSKLESVISD EGDLQFPSPK ISSSPKFDSR DNALSASNET 1390 1400 1410 1420 1430 1440 SSAEHLKDGT MKEMVVCSSE SITCKPQLKD SFISNSLPTF FYIPQQDPLK TNSQLDTSIQ 1450 1460 1470 1480 1490 1500 RNKLLENEDT AGEALTLDIN RETRRYHCSG KDQIVPSLNT ESSNPVLKKL EKLNTEKEER 1510 1520 1530 1540 1550 1560 QKQLQQQNEK EMMEQIRQQT DILEKERKAF KTIEKPRIGE CLVAPSSYQS KQRVERPSSL 1570 1580 1590 1600 1610 1620 LSLNTSNKGE LNVLGSLSLK DAALAQKDSS SAHLPPKDRP VTVFFERKGS PCQSSTVKEL 1630 1640 1650 1660 1670 1680 SKTDRMGTQL NVACKLSNNR ISKREHFRPT QSYSHNSDDL SREGNARPIF FTPKDNMSIP 1690 1700 1710 1720 1730 1740 LVSKEALNSK NPQLHKEDEP AWKPVKLAGP GQREVARPAH KKKARMARTR SDFLTRGTFA 1750 1760 1770 1780 1790 1800 DGEGDTEEDD YDDIIEPLLS LDQASHCELG PAPSLGQASH SDSEMTSQRF SSVDEQAKLH 1810 1820 1830 1840 1850 1860 KTMSQGEITK LAVRQKASDS DIRPQRAKMR FWAKGKQGEK KTTRVKPTTQ SEVSPLFAGT 1870 1880 1890 1900 1910 1920 DVIPAHQFPD ELAAYHPTPP LSPELPGSCR KEFKENKEPS PKAKRKRSVK ISNVALDSMH 1930 1940 1950 1960 1970 1980 WQNDSVQIIA SVSDLKSMDE FLLKKVNDLD NEDSKKDTLV DVVFKKALKE FRQNIFSFYS 1990 2000 2010 2020 2030 2040 SALAMDDGKS IRYKDLYALF EQILEKTMRL EQRDSLGESP VRVWVNTFKV FLDEYMNEFK 2050 2060 2070 2080 2090 2100 TSDCTATKVP KTERKKRRKK ETDLVEEHNG HIFKATQYSI PTYCEYCSSL IWIMDRASVC 2110 2120 2130 2140 2150 2160 KLCKYACHKK CCLKTTAKCS KKYDPELSSR QFGVELSRLT SEDRTVPLVV EKLINYIEMH 2170 2180 2190 2200 2210 2220 GLYTEGIYRK SGSTNKIKEL RQGLDTDAES VNLDDYNIHV IASVFKQWLR DLPNPLMTFE 2230 2240 2250 2260 2270 2280 LYEEFLRAMG LQERKETIRG VYSVIDQLSR THLNTLERLI FHLVRIALQE DTNRMSANAL 2290 2300 2310 2320 2330 2340 AIVFAPCILR CPDTTDPLQS VQDISKTTTC VELIVVEQMN KYKARLKDIS SLEFAENKAK 2350 2360 2370 2380 2390 2400 TRLSLIRRSM GKGRIRRGNY PGPSSPVVVR LPSVSDVSEE TLTSEAAMET DITEQQQAAM 2410 2420 2430 2440 2450 2460 QQEERVLTEQ IENLQKEKEE LTFEMLVLEP RASDDETLES EASIGTADSS ENLNMESEYA 2470 2480 2490 2500 2510 2520 ISEKSERSLA LSSLKTAGKS EPSSKLRKQL KKQQDSLDVV DSSVSSLCLS NTASSHGTRK 2530 2540 2550 2560 2570 2580 LFQIYSKSPF YRAASGNEAL GMEGPLGQTK FLEDKPQFIS RGTFNPEKGK QKLKNVKNSP 2590 2600 2610 QKTKETPEGT VMSGRRKTVD PDCTSNQQLA LFGNNEFMV
	Isoform 5 [UniParc]. Checksum: D00A255132D264DC	FASTA	2,312	265,414
	10 20 30 40 50 60 MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEAFGNAK TAHNNNSSRF 70 80 90 100 110 120 GKFIQVNYQE TGTVLGAYVE KYLLEKSRLV YQEHNERNYH VFYYLLAGAS EDERSAFHLK 130 140 150 160 170 180 QPEEYHYLNQ ITKKPLRQSW DDYCYDSEPD CFTVEGEDLR HDFERLQLAM EMVGFLPKTR 190 200 210 220 230 240 RQIFSLLSAI LHLGNICYKK KTYRDDSIDI CNPEVLPIVS ELLEVKEEML FEALVTRKTV 250 260 270 280 290 300 TVGEKLILPY KLAEAVTVRN SMAKSLYSAL FDWIVFRINH ALLNSKDLEH NTKTLSIGVL 310 320 330 340 350 360 DIFGFEDYEN NSFEQFCINF ANERLQHYFN QHIFKLEQEE YRTEGISWHN IDYIDNTCCI 370 380 390 400 410 420 NLISKKPTGL LHLLDEESNF PQATNQTLLD KFKHQHEDNS YIEFPAVMEP AFIIKHYAGK 430 440 450 460 470 480 VKYGVKDFRE KNTDHMRPDI VALLRSSKNA FISGMIGIDP VAVFRWAILR AFFRAMVAFR 490 500 510 520 530 540 EAGKRNIHRK TGHDDTAPCA ILKSMDSFSF LQHPVHQRSL EILQRCKEEK YSITRKNPRT 550 560 570 580 590 600 PLSDLQGMNA LNEKNQHDTF DIAWNGRTGI RQSRLSSGTS LLDKDGIFAN STSSKLLERA 610 620 630 640 650 660 HGILTRNKNF KSKPALPKHL LEVNSLKHLT RLTLQDRITK SLLHLHKKKK PPSISAQFQA 670 680 690 700 710 720 SLSKLMETLG QAEPYFVKCI RSNAEKLPLR FSDVLVLRQL RYTGMLETVR IRQSGYSSKY 730 740 750 760 770 780 SFQDFVSHFH VLLPRNIIPS KFNIQDFFRK INLNPDNYQV GKTMVFLKEQ ERQHLQDLLH 790 800 810 820 830 840 QEVLRRIILL QRWFRVLLCR QHFLHLRQAS VIIQRFWRNY LNQKQVRDAA VQKDAFVMAS 850 860 870 880 890 900 AAALLQASWR AHLERQRYLE LRAAAIVIQQ KWRDYYRRRH MAAICIQARW KAYRESKRYQ 910 920 930 940 950 960 EQRKKIILLQ STCRGFRARQ RFKALKEQRL RETKPEVGLV NIKGYGSLEI QGSDPSGWED 970 980 990 1000 1010 1020 CSFDNRIKAI EECKSVIESN RISRESSVDC LKESPNKQQE RAQSQSGVDL QEDVLVRERP 1030 1040 1050 1060 1070 1080 RSLEDLHQKK VGRAKRESRR MRELEQAIFS LELLKVRSLG GISPSEDRRW STELVPEGLQ 1090 1100 1110 1120 1130 1140 SPRGTPDSES SQGSLELLSY EESQKSKLES VISDEGDLQF PSPKISSSPK FDSRDNALSA 1150 1160 1170 1180 1190 1200 SNETSSAEHL KDGTMKEMVV CSSESITCKP QLKDSFISNS LPTFFYIPQQ DPLKTNSQLD 1210 1220 1230 1240 1250 1260 TSIQRNKLLE NEDTAGEALT LDINRETRRY HCSGKDQIVP SLNTESSNPV LKKLEKLNTE 1270 1280 1290 1300 1310 1320 KEERQKQLQQ QNEKEMMEQI RQQTDILEKE RKAFKTIEKP RIGECLVAPS SYQSKQRVER 1330 1340 1350 1360 1370 1380 PSSLLSLNTS NKGELNVLGS LSLKDAALAQ KDSSSAHLPP KDRPVTVFFE RKGSPCQSST 1390 1400 1410 1420 1430 1440 VKELSKTDRM GTQLNVACKL SNNRISKREH FRPTQSYSHN SDDLSREGNA RPIFFTPKDN 1450 1460 1470 1480 1490 1500 MSIPLVSKEA LNSKNPQLHK EDEPAWKPVK LAGPGQRETS QRFSSVDEQA KLHKTMSQGE 1510 1520 1530 1540 1550 1560 ITKLAVRQKA SDSDIRPQRA KMRFWAKGKQ GEKKTTRVKP TTQSEVSPLF AGTDVIPAHQ 1570 1580 1590 1600 1610 1620 FPDELAAYHP TPPLSPELPG SCRKEFKENK EPSPKAKRKR SVKISNVALD SMHWQNDSVQ 1630 1640 1650 1660 1670 1680 IIASVSDLKS MDEFLLKKVN DLDNEDSKKD TLVDVVFKKA LKEFRQNIFS FYSSALAMDD 1690 1700 1710 1720 1730 1740 GKSIRYKDLY ALFEQILEKT MRLEQRDSLG ESPVRVWVNT FKVFLDEYMN EFKTSDCTAT 1750 1760 1770 1780 1790 1800 KVPKTERKKR RKKETDLVEE HNGHIFKATQ YSIPTYCEYC SSLIWIMDRA SVCKLCKYAC 1810 1820 1830 1840 1850 1860 HKKCCLKTTA KCSKKYDPEL SSRQFGVELS RLTSEDRTVP LVVEKLINYI EMHGLYTEGI 1870 1880 1890 1900 1910 1920 YRKSGSTNKI KELRQGLDTD AESVNLDDYN IHVIASVFKQ WLRDLPNPLM TFELYEEFLR 1930 1940 1950 1960 1970 1980 AMGLQERKET IRGVYSVIDQ LSRTHLNTLE RLIFHLVRIA LQEDTNRMSA NALAIVFAPC 1990 2000 2010 2020 2030 2040 ILRCPDTTDP LQSVQDISKT TTCVELIVVE QMNKYKARLK DISSLEFAEN KAKTRLSLIR 2050 2060 2070 2080 2090 2100 RSMGKGRIRR GNYPGPSSPV VVRLPSVSDV SEETLTSEAA METDITEQQQ AAMQQEERVL 2110 2120 2130 2140 2150 2160 TEQIENLQKE KEELTFEMLV LEPRASDDET LESEASIGTA DSSENLNMES EYAISEKSER 2170 2180 2190 2200 2210 2220 SLALSSLKTA GKSEPSSKLR KQLKKQQDSL DVVDSSVSSL CLSNTASSHG TRKLFQIYSK 2230 2240 2250 2260 2270 2280 SPFYRAASGN EALGMEGPLG QTKFLEDKPQ FISRGTFNPE KGKQKLKNVK NSPQKTKETP 2290 2300 2310 EGTVMSGRRK TVDPDCTSNQ QLALFGNNEF MV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23." Gorman S.W., Haider N.B., Grieshammer U., Swiderski R.E., Kim E., Welch J.W., Searby C., Leng S., Carmi R., Sheffield V.C., Duhl D.M. Genomics 59:150-160(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5), TISSUE SPECIFICITY, VARIANTS GLN-85; ASP-168; PRO-211; GLN-946; GLU-1193; PRO-1362 AND CYS-1834.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-1193.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS LYS-37 AND GLU-1193. Tissue: Placenta.
[5]	"Myr 7 is a novel myosin IX-RhoGAP expressed in rat brain." Chieregatti E., Gaertner A., Stoeffler H.-E., Baehler M. J. Cell Sci. 111:3597-3608(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-774 (ISOFORMS 1/4).
[6]	"Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins." Yamakawa H., Kikuno R.F., Nagase T., Ohara O. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-2548 (ISOFORM 1), VARIANT GLU-1193. Tissue: Brain.
[7]	"Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types." Bement W.M., Hasson T., Wirth J.A., Cheney R.E., Mooseker M.S. Proc. Natl. Acad. Sci. U.S.A. 91:6549-6553(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 234-322 (ISOFORMS 1/2/3/4).
[8]	"Non-EST based prediction of exon skipping and intron retention events using Pfam information." Hiller M., Huse K., Platzer M., Backofen R. Nucleic Acids Res. 33:5611-5621(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 292-445 (ISOFORMS 1/2/3/4/5).
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1223-2548 (ISOFORM 4). Tissue: Testis.
[10]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1457-1981 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1984-2548 (ISOFORMS 1/2/4/5). Tissue: Ovary and Placenta.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF117888 mRNA. Translation: AAD49195.1. AC020779 Genomic DNA. No translation available. AC022872 Genomic DNA. No translation available. AC090454 Genomic DNA. No translation available. AC104938 Genomic DNA. No translation available. CH471082 Genomic DNA. Translation: EAW77880.1. BC060886 mRNA. Translation: AAH60886.1. BC140869 mRNA. Translation: AAI40870.1. AJ001714 mRNA. Translation: CAA04947.1. AB290183 mRNA. Translation: BAG06737.1. L29148 mRNA. Translation: AAA20911.1. DQ088983 mRNA. Translation: AAZ85978.1. DQ088984 mRNA. Translation: AAZ85979.1. AL137287 mRNA. Translation: CAB70679.1. AK001923 mRNA. Translation: BAA91979.1. Different initiation. AK023306 mRNA. Translation: BAB14517.1. Different initiation.
IPI	IPI00018057. IPI00160131. IPI00902852. IPI00902943. IPI00953559.
PIR	E59435. I61699. T46354.
RefSeq	NP_008832.2. NM_006901.3.
UniGene	Hs.546268. Hs.733087.
3D structure databases
ProteinModelPortal	B2RTY4.
SMR	B2RTY4. Positions 149-696, 816-1058, 1993-2244.
ModBase	Search...
Protein-protein interaction databases
IntAct	B2RTY4. 5 interactions.
MINT	MINT-1425451.
Proteomic databases
PaxDb	B2RTY4.
PeptideAtlas	Q14787.
PRIDE	B2RTY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356056; ENSP00000348349; ENSG00000066933. ENST00000424560; ENSP00000399162; ENSG00000066933. ENST00000444904; ENSP00000398250; ENSG00000066933.
GeneID	4649.
KEGG	hsa:4649.
UCSC	uc002atk.3. human. uc002atl.4. human. uc002ato.3. human.
Organism-specific databases
CTD	4649.
GeneCards	GC15M072114.
H-InvDB	HIX0012401.
HGNC	HGNC:7608. MYO9A.
HPA	HPA039812. HPA040071.
MIM	604875. gene.
neXtProt	NX_B2RTY4.
PharmGKB	PA31413.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5022.
HOVERGEN	HBG108165.
InParanoid	B2RTY4.
KO	K10360.
OMA	TCKPQLR.
OrthoDB	EOG4FJ87W.
PhylomeDB	B2RTY4.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	B2RTY4.
Bgee	B2RTY4.
Genevestigator	B2RTY4.
Family and domain databases
Gene3D	1.10.555.10. 1 hit.
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR001609. Myosin_head_motor_dom. IPR002219. Prot_Kinase_C-like_PE/DAG-bd. IPR000159. Ras-assoc. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Pfam	PF00612. IQ. 4 hits. PF00063. Myosin_head. 2 hits. PF00788. RA. 1 hit. PF00620. RhoGAP. 1 hit. [Graphical view]
PRINTS	PR00193. MYOSINHEAVY.
SMART	SM00109. C1. 1 hit. SM00015. IQ. 5 hits. SM00242. MYSc. 1 hit. SM00314. RA. 1 hit. SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50096. IQ. 4 hits. PS50200. RA. 1 hit. PS50238. RHOGAP. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4649.
NextBio	17924.
SOURCE	Search...

Entry information

Entry name

MYO9A_HUMAN

Accession

Primary (citable) accession number: B2RTY4
Secondary accession number(s): B0I1T5 , C9IYB3, C9JA86, Q14787, Q3YLD7, Q3YLD8, Q6P986, Q9H8T5, Q9NTG2, Q9NUY2, Q9UEP3, Q9UNJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.