Arhgap35

Functionⁱ

GO - Molecular functionⁱ

GTPase activator activity Source: Ensembl
GTPase activity Source: InterPro
GTP binding Source: InterPro
phospholipid binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

axonal fasciculation Source: Ensembl
axon guidance Source: Ensembl
camera-type eye development Source: Ensembl
cellular response to extracellular stimulus Source: Ensembl
central nervous system neuron axonogenesis Source: Ensembl
establishment or maintenance of actin cytoskeleton polarity Source: Ensembl
forebrain development Source: Ensembl
mammary gland development Source: Ensembl
negative regulation of Rho protein signal transduction Source: Ensembl
negative regulation of vascular permeability Source: Ensembl
neural tube closure Source: Ensembl
positive regulation of cilium assembly Source: Ensembl
positive regulation of neuron projection development Source: Ensembl
regulation of actin polymerization or depolymerization Source: Ensembl
regulation of axonogenesis Source: Ensembl
regulation of cell shape Source: Ensembl
signal transduction Source: InterPro
wound healing, spreading of cells Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	ReceptorImported

Molecular function

ReceptorImported

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Glucocorticoid receptor DNA binding factor 1Imported Submitted name: Grlf1 proteinImported
Gene namesⁱ	Name:Arhgap35Imported Synonyms:Grlf1Imported ORF Names:mCG_2086Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:1929494. Arhgap35.

Subcellular locationⁱ

GO - Cellular componentⁱ

actin cytoskeleton Source: Ensembl
ciliary basal body Source: Ensembl
cytoplasm Source: Ensembl

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000058230.
ExpressionAtlasⁱ	B2RTN5. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	B2RTN5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	270 – 327	FFInterPro annotationAdd BLAST	58
Domainⁱ	368 – 422	FFInterPro annotationAdd BLAST	55
Domainⁱ	429 – 483	FFInterPro annotationAdd BLAST	55
Domainⁱ	485 – 550	FFInterPro annotationAdd BLAST	66
Domainⁱ	1249 – 1436	Rho-GAPInterPro annotationAdd BLAST	188

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	413 – 440	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4271. Eukaryota. ENOG410XR4E. LUCA.
HOGENOMⁱ	HOG000001561.
HOVERGENⁱ	HBG051844.
KEGG Orthology (KO) More...KOⁱ	K05732.
OMAⁱ	MLRAFLC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00ZO.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002713. FF_domain. IPR027417. P-loop_NTPase. IPR008936. Rho_GTPase_activation_prot. IPR032835. RhoGAP-FF1. IPR000198. RhoGAP_dom. IPR001806. Small_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01846. FF. 1 hit. PF00071. Ras. 1 hit. PF00620. RhoGAP. 1 hit. PF16512. RhoGAP-FF1. 1 hit.
SMARTⁱ	View protein in SMART SM00441. FF. 4 hits. SM00324. RhoGAP. 1 hit.
SUPFAMⁱ	SSF48350. SSF48350. 1 hit. SSF52540. SSF52540. 2 hits. SSF81698. SSF81698. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51676. FF. 4 hits. PS50238. RHOGAP. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B2RTN5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF 
        60         70         80         90        100
HLDHTSVLST SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHIVEQTEFI 
       110        120        130        140        150
DDQTFQPHRS TALQPYIKRA AATKLASAEK LMYFCTDQLG LEQDFEQKQM 
       160        170        180        190        200
PDGKLLVDGF LLGIDVSRGM NRNFDDQLKF VSNLYNQLAK TKKPIVVVLT 
       210        220        230        240        250
KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF STLVQLIDKS 
       260        270        280        290        300
RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWPSVSRKMQ 
       310        320        330        340        350
ASPEYQDYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA 
       360        370        380        390        400
LIPNLDEVDH LSCIKAKKLL ETKPEFLKWF VVLEETPWDA TSHIDNMENE 
       410        420        430        440        450
RIPFDLMDTV PAEQLYETHL EKLRNERKRA EMRRAFKENL ETSPFITPGK 
       460        470        480        490        500
PWEEARSFIM NEDFYQWLEE SVYMDIYGKH QKQIIDRAKE EFQELLLEYS 
       510        520        530        540        550
ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER DALILKHIHF 
       560        570        580        590        600
VYHPTKETCP SCPACVDAKI EHLISSRFIR PSDRNQKNSL SDLNIDRINL 
       610        620        630        640        650
VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS 
       660        670        680        690        700
FQTPTFQPHG CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL 
       710        720        730        740        750
ILVNKRGDTS GETLHSLIQQ GQQIASKLQC VFLDPASAGI GYGRNINEKQ 
       760        770        780        790        800
ISQVLKGLLD SKRNLNLVSS TASIKDLADV DLRIVMCLMC GDPFSADDVL 
       810        820        830        840        850
SPVLQSQTCK SSHCGSSNSV LLELPIGLHK KRIELSVLSY HSSFSIRKSR 
       860        870        880        890        900
LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPIQLVALTD GAIDVLDNDL 
       910        920        930        940        950
SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LELFHPFFKD VVEKKNIIEA 
       960        970        980        990       1000
THMYDNVAEA CSTTEEVFNS PRAGSPLCNS NLQDSEEDVE PPSYHLFRED 
      1010       1020       1030       1040       1050
ATLPSLSKDH SKFSMELEGN DGLSFIMSNF ESKLNNKVPP PVKPKPPVHF 
      1060       1070       1080       1090       1100
DITKDLSYLD QGHREGQRKS MSSSPWMPQD GFDPSDYAEP MDAVVKPRNE 
      1110       1120       1130       1140       1150
EENIYSVPHD STQGKIITIR NINKAQSNGS GNGSDSEMDT SSLERGRKVS 
      1160       1170       1180       1190       1200
AVSKPVLYRT RCTRLGRFAS YRTSFSVGSD DELGPIRKKE EDQASQGYKG 
      1210       1220       1230       1240       1250
DNAVIPYETD EDPRRRNILR SLRRNTKKPK PKPRPSITKA TWESNYFGVP 
      1260       1270       1280       1290       1300
LTTVVTPEKP IPIFIERCIE YIEATGLSTE GIYRVSGNKS EMESLQRQFD 
      1310       1320       1330       1340       1350
QDHNLDLAEK DFTVNTVAGA MKSFFSELPD PLVPYSMQID LVEAHKINDR 
      1360       1370       1380       1390       1400
EQKLHALKEV LKKFPKENHE VFKYVISHLN KVSHNNKVNL MTSENLSICF 
      1410       1420       1430       1440       1450
WPTLMRPDFS SMDALTATRS YQTIIELFIQ QCPFFFYNRP ISEPPGAAPG 
      1460       1470       1480       1490 
SPSAMAPTVP FLTSTPATSQ PSPPQSPPPT PQSPMQPLLS SQLQAEHTL

Length:1,499

Mass (Da):170,393

Last modified:July 1, 2008 - v1

Checksum:ⁱ7E13EC38257CE950

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC139459 mRNA. Translation: AAI39460.1. BC139461 mRNA. Translation: AAI39462.1. CH466654 Genomic DNA. Translation: EDL42088.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_766327.3. NM_172739.4. XP_006539872.1. XM_006539809.3. XP_011248814.1. XM_011250512.2.
UniGeneⁱ	Mm.28646. Mm.400358.

Genome annotation databases

GeneIDⁱ	232906.
KEGGⁱ	mmu:232906.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC139459 mRNA. Translation: AAI39460.1. BC139461 mRNA. Translation: AAI39462.1. CH466654 Genomic DNA. Translation: EDL42088.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_766327.3. NM_172739.4. XP_006539872.1. XM_006539809.3. XP_011248814.1. XM_011250512.2.
UniGeneⁱ	Mm.28646. Mm.400358.

3D structure databases

SMRⁱ	B2RTN5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	232906.
KEGGⁱ	mmu:232906.

Organism-specific databases

CTDⁱ	2909.
MGIⁱ	MGI:1929494. Arhgap35.

Phylogenomic databases

eggNOGⁱ	KOG4271. Eukaryota. ENOG410XR4E. LUCA.
HOGENOMⁱ	HOG000001561.
HOVERGENⁱ	HBG051844.
KEGG Orthology (KO) More...KOⁱ	K05732.
OMAⁱ	MLRAFLC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00ZO.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000058230.
ExpressionAtlasⁱ	B2RTN5. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002713. FF_domain. IPR027417. P-loop_NTPase. IPR008936. Rho_GTPase_activation_prot. IPR032835. RhoGAP-FF1. IPR000198. RhoGAP_dom. IPR001806. Small_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01846. FF. 1 hit. PF00071. Ras. 1 hit. PF00620. RhoGAP. 1 hit. PF16512. RhoGAP-FF1. 1 hit.
SMARTⁱ	View protein in SMART SM00441. FF. 4 hits. SM00324. RhoGAP. 1 hit.
SUPFAMⁱ	SSF48350. SSF48350. 1 hit. SSF52540. SSF52540. 2 hits. SSF81698. SSF81698. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51676. FF. 4 hits. PS50238. RHOGAP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2RTN5_MOUSE
Accessionⁱ	B2RTN5Primary (citable) accession number: B2RTN5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 1, 2008
	Last sequence update:	July 1, 2008
	Last modified:	July 5, 2017
	This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - B2RTN5 (B2RTN5_MOUSE)

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Glucocorticoid receptor DNA binding factor 1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2RTN5 (B2RTN5_MOUSE)

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Glucocorticoid receptor DNA binding factor 1

Arhgap35

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ