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Protein

Histone H4

Gene

Hist2h4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4UniRule annotation
Gene namesi
Name:Hist2h4Imported
Synonyms:Hist1h4cImported, Hist1h4mImported, RP23-38E20.3Imported
ORF Names:mCG_1027097Imported, mCG_1044802Imported, mCG_121063Imported, mCG_142242Imported, mCG_23033Imported, mCG_23039Imported, mCG_49272Imported, mCG_49679Imported, mCG_7726Imported, mCG_7729Imported, mCG_7731Imported, RP23-283N14.21-001Imported, RP23-38E20.3-001Imported, RP23-38E20.4-001Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

TopDownProteomicsiB2RTM0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060093.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-8297447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 93TAFInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the histone H4 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOVERGENiHBG051878.
KOiK11254.
OMAiYEEVRVV.
OrthoDBiEOG091G0XGD.

Family and domain databases

CDDicd00076. H4. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
IPR004823. TAF_TATA-bd.
PRINTSiPR00623. HISTONEH4.
SMARTiView protein in SMART
SM00417. H4. 1 hit.
SM00803. TAF. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00047. HISTONE_H4. 1 hit.

Sequencei

Sequence statusi: Complete.

B2RTM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:July 1, 2008 - v1
Checksum:iA9E5DFD3F8B97598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139425 mRNA. Translation: AAI39426.1.
BC139437 mRNA. Translation: AAI39438.1.
AL592149 Genomic DNA. Translation: CAI24885.1.
AL589879 Genomic DNA. Translation: CAI25464.1.
AL589879 Genomic DNA. Translation: CAI25465.1.
CH466572 Genomic DNA. Translation: EDL10567.1.
CH466572 Genomic DNA. Translation: EDL10574.1.
CH466561 Genomic DNA. Translation: EDL32537.1.
CH466561 Genomic DNA. Translation: EDL32545.1.
CH466561 Genomic DNA. Translation: EDL32551.1.
CH466561 Genomic DNA. Translation: EDL32558.1.
CH466561 Genomic DNA. Translation: EDL32563.1.
CH466561 Genomic DNA. Translation: EDL32608.1.
CH466561 Genomic DNA. Translation: EDL32622.1.
CH466561 Genomic DNA. Translation: EDL32632.1.
CH466620 Genomic DNA. Translation: EDL38881.1.
RefSeqiNP_001182350.1. NM_001195421.1.
NP_291074.1. NM_033596.3.
NP_694813.1. NM_153173.4.
NP_783583.1. NM_175652.3.
NP_783585.1. NM_175654.2.
NP_783586.1. NM_175655.2.
NP_783587.1. NM_175656.3.
NP_783588.1. NM_175657.2.
NP_835499.1. NM_178192.2.
NP_835500.1. NM_178193.2.
NP_835515.1. NM_178208.2.
NP_835582.1. NM_178210.2.
NP_835583.1. NM_178211.2.
UniGeneiMm.14775.
Mm.158272.
Mm.227295.
Mm.228709.
Mm.246720.
Mm.255646.
Mm.260530.
Mm.261642.
Mm.261662.
Mm.261664.
Mm.442307.
Mm.486099.

Genome annotation databases

GeneIDi100041230.
319155.
319156.
319157.
319158.
319159.
319160.
319161.
320332.
326619.
326620.
69386.
97122.
KEGGimmu:100041230.
mmu:319155.
mmu:319156.
mmu:319157.
mmu:319158.
mmu:319159.
mmu:319160.
mmu:319161.
mmu:320332.
mmu:326619.
mmu:326620.
mmu:69386.
mmu:97122.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB2RTM0_MOUSE
AccessioniPrimary (citable) accession number: B2RTM0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 5, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)