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Protein

Histone H4

Gene

Hist2h4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4UniRule annotation
Gene namesi
Name:Hist2h4Imported
Synonyms:Hist1h4cImported, Hist1h4mImported, RP23-38E20.3Imported
ORF Names:mCG_1027097Imported, mCG_1044802Imported, mCG_121063Imported, mCG_142242Imported, mCG_23033Imported, mCG_23039Imported, mCG_49272Imported, mCG_49679Imported, mCG_7726Imported, mCG_7729Imported, mCG_7731Imported, RP23-283N14.21-001Imported, RP23-38E20.3-001Imported, RP23-38E20.4-001Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

TopDownProteomicsiB2RTM0

Expressioni

Gene expression databases

BgeeiENSMUSG00000060093

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

IntActiB2RTM0, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 93TAFInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the histone H4 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
HOVERGENiHBG051878
KOiK11254
OMAiHINGITK
OrthoDBiEOG091G0XGD

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
IPR004823 TAF_TATA-bd
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

Sequencei

Sequence statusi: Complete.

B2RTM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:July 1, 2008 - v1
Checksum:iA9E5DFD3F8B97598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139425 mRNA Translation: AAI39426.1
BC139437 mRNA Translation: AAI39438.1
AL592149 Genomic DNA Translation: CAI24885.1
AL589879 Genomic DNA Translation: CAI25464.1
AL589879 Genomic DNA Translation: CAI25465.1
CH466572 Genomic DNA Translation: EDL10567.1
CH466572 Genomic DNA Translation: EDL10574.1
CH466561 Genomic DNA Translation: EDL32537.1
CH466561 Genomic DNA Translation: EDL32545.1
CH466561 Genomic DNA Translation: EDL32551.1
CH466561 Genomic DNA Translation: EDL32558.1
CH466561 Genomic DNA Translation: EDL32563.1
CH466561 Genomic DNA Translation: EDL32608.1
CH466561 Genomic DNA Translation: EDL32622.1
CH466561 Genomic DNA Translation: EDL32632.1
CH466620 Genomic DNA Translation: EDL38881.1
RefSeqiNP_001182350.1, NM_001195421.1
NP_291074.1, NM_033596.3
NP_694813.1, NM_153173.4
NP_783583.1, NM_175652.3
NP_783585.1, NM_175654.2
NP_783586.1, NM_175655.2
NP_783587.1, NM_175656.3
NP_783588.1, NM_175657.2
NP_835499.1, NM_178192.2
NP_835500.1, NM_178193.2
NP_835515.1, NM_178208.2
NP_835582.1, NM_178210.2
NP_835583.1, NM_178211.2
UniGeneiMm.14775
Mm.158272
Mm.227295
Mm.228709
Mm.246720
Mm.255646
Mm.260530
Mm.261642
Mm.261662
Mm.261664
Mm.442307
Mm.486099

Genome annotation databases

GeneIDi100041230
319155
319156
319157
319158
319159
319160
319161
320332
326619
326620
69386
97122
KEGGimmu:100041230
mmu:319155
mmu:319156
mmu:319157
mmu:319158
mmu:319159
mmu:319160
mmu:319161
mmu:320332
mmu:326619
mmu:326620
mmu:69386
mmu:97122

Similar proteinsi

Entry informationi

Entry nameiB2RTM0_MOUSE
AccessioniPrimary (citable) accession number: B2RTM0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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