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Protein

Histone H4

Gene

Hist2h4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4UniRule annotation
Gene namesi
Name:Hist2h4Imported
Synonyms:Hist1h4cImported, Hist1h4mImported, RP23-38E20.3Imported
ORF Names:mCG_1027097Imported, mCG_1044802Imported, mCG_121063Imported, mCG_142242Imported, mCG_23033Imported, mCG_23039Imported, mCG_49272Imported, mCG_49679Imported, mCG_7726Imported, mCG_7729Imported, mCG_7731Imported, RP23-283N14.21-001Imported, RP23-38E20.3-001Imported, RP23-38E20.4-001Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

TopDownProteomicsiB2RTM0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060093.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-8297447.
STRINGi10090.ENSMUSP00000136357.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 9366TAFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the histone H4 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOVERGENiHBG051878.
KOiK11254.
OMAiSTHNERI.
OrthoDBiEOG091G0XGD.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
IPR004823. TAF_TATA-bd.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
SM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B2RTM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,367
Last modified:July 1, 2008 - v1
Checksum:iA9E5DFD3F8B97598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139425 mRNA. Translation: AAI39426.1.
BC139437 mRNA. Translation: AAI39438.1.
AL592149 Genomic DNA. Translation: CAI24885.1.
AL589879 Genomic DNA. Translation: CAI25464.1.
AL589879 Genomic DNA. Translation: CAI25465.1.
CH466572 Genomic DNA. Translation: EDL10567.1.
CH466572 Genomic DNA. Translation: EDL10574.1.
CH466561 Genomic DNA. Translation: EDL32537.1.
CH466561 Genomic DNA. Translation: EDL32545.1.
CH466561 Genomic DNA. Translation: EDL32551.1.
CH466561 Genomic DNA. Translation: EDL32558.1.
CH466561 Genomic DNA. Translation: EDL32563.1.
CH466561 Genomic DNA. Translation: EDL32608.1.
CH466561 Genomic DNA. Translation: EDL32622.1.
CH466561 Genomic DNA. Translation: EDL32632.1.
CH466620 Genomic DNA. Translation: EDL38881.1.
RefSeqiNP_001182350.1. NM_001195421.1.
NP_291074.1. NM_033596.3.
NP_694813.1. NM_153173.4.
NP_783583.1. NM_175652.3.
NP_783585.1. NM_175654.2.
NP_783586.1. NM_175655.2.
NP_783587.1. NM_175656.3.
NP_783588.1. NM_175657.2.
NP_835499.1. NM_178192.2.
NP_835500.1. NM_178193.2.
NP_835515.1. NM_178208.2.
NP_835582.1. NM_178210.2.
NP_835583.1. NM_178211.2.
XP_006544162.1. XM_006544099.2.
UniGeneiMm.14775.
Mm.158272.
Mm.227295.
Mm.228709.
Mm.246720.
Mm.255646.
Mm.260530.
Mm.261642.
Mm.261662.
Mm.261664.
Mm.442307.
Mm.486099.

Genome annotation databases

GeneIDi100041230.
102641229.
319155.
319156.
319157.
319158.
319159.
319160.
319161.
320332.
326619.
326620.
69386.
97122.
KEGGimmu:100041230.
mmu:102641229.
mmu:319155.
mmu:319156.
mmu:319157.
mmu:319158.
mmu:319159.
mmu:319160.
mmu:319161.
mmu:320332.
mmu:326619.
mmu:326620.
mmu:69386.
mmu:97122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139425 mRNA. Translation: AAI39426.1.
BC139437 mRNA. Translation: AAI39438.1.
AL592149 Genomic DNA. Translation: CAI24885.1.
AL589879 Genomic DNA. Translation: CAI25464.1.
AL589879 Genomic DNA. Translation: CAI25465.1.
CH466572 Genomic DNA. Translation: EDL10567.1.
CH466572 Genomic DNA. Translation: EDL10574.1.
CH466561 Genomic DNA. Translation: EDL32537.1.
CH466561 Genomic DNA. Translation: EDL32545.1.
CH466561 Genomic DNA. Translation: EDL32551.1.
CH466561 Genomic DNA. Translation: EDL32558.1.
CH466561 Genomic DNA. Translation: EDL32563.1.
CH466561 Genomic DNA. Translation: EDL32608.1.
CH466561 Genomic DNA. Translation: EDL32622.1.
CH466561 Genomic DNA. Translation: EDL32632.1.
CH466620 Genomic DNA. Translation: EDL38881.1.
RefSeqiNP_001182350.1. NM_001195421.1.
NP_291074.1. NM_033596.3.
NP_694813.1. NM_153173.4.
NP_783583.1. NM_175652.3.
NP_783585.1. NM_175654.2.
NP_783586.1. NM_175655.2.
NP_783587.1. NM_175656.3.
NP_783588.1. NM_175657.2.
NP_835499.1. NM_178192.2.
NP_835500.1. NM_178193.2.
NP_835515.1. NM_178208.2.
NP_835582.1. NM_178210.2.
NP_835583.1. NM_178211.2.
XP_006544162.1. XM_006544099.2.
UniGeneiMm.14775.
Mm.158272.
Mm.227295.
Mm.228709.
Mm.246720.
Mm.255646.
Mm.260530.
Mm.261642.
Mm.261662.
Mm.261664.
Mm.442307.
Mm.486099.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8297447.
STRINGi10090.ENSMUSP00000136357.

Proteomic databases

TopDownProteomicsiB2RTM0.

Protocols and materials databases

DNASUi319156.
319157.
319159.
320332.
326620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100041230.
102641229.
319155.
319156.
319157.
319158.
319159.
319160.
319161.
320332.
326619.
326620.
69386.
97122.
KEGGimmu:100041230.
mmu:102641229.
mmu:319155.
mmu:319156.
mmu:319157.
mmu:319158.
mmu:319159.
mmu:319160.
mmu:319161.
mmu:320332.
mmu:326619.
mmu:326620.
mmu:69386.
mmu:97122.

Organism-specific databases

CTDi100041230.
121504.
319161.
8294.
8359.
8360.
8361.
8362.
8363.
8364.
8365.
8366.
97122.

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOVERGENiHBG051878.
KOiK11254.
OMAiSTHNERI.
OrthoDBiEOG091G0XGD.

Gene expression databases

BgeeiENSMUSG00000060093.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
IPR004823. TAF_TATA-bd.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
SM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2RTM0_MOUSE
AccessioniPrimary (citable) accession number: B2RTM0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.